초록 ▼

Methods of performing medical procedures, and methods of making bone-growth-promoting compositions useful in performing medical procedures are provided. Apparatus useful both in methods of performing medical procedures, and in methods of making bone-growth-promoting compositions useful in performing

Methods of performing medical procedures, and methods of making bone-growth-promoting compositions useful in performing medical procedures are provided. Apparatus useful both in methods of performing medical procedures, and in methods of making bone-growth-promoting compositions useful in performing medical procedures, are provided. The bone-growth-promoting compositions made according to the disclosed methods are biocompatible, and are adapted to stimulate bone growth when positioned in contact with, or in the vicinity of, a bone of a mammal.

대표청구항 ▼

1. A polyurethane composition having in its cured state an average pore size ranging from about 5 microns to about 500 microns, wherein the polyurethane composition is biocompatible and suitable for use in vivo; wherein the polyurethane composition comprises calcium carbonate present in an amount ra

1. A polyurethane composition having in its cured state an average pore size ranging from about 5 microns to about 500 microns, wherein the polyurethane composition is biocompatible and suitable for use in vivo; wherein the polyurethane composition comprises calcium carbonate present in an amount ranging from about 0.01% to about 55% by weight, wherein the polyurethane composition is made by the process of combining a polyol, an isocyanate, and water, and the water is present in an amount ranging from about 0.05% to about 1% by weight. 2. The polyurethane composition of claim 1, wherein the process further comprises the inclusion of a cross-linker. 3. The polyurethane composition of claim 2, wherein the cross-linker is a trifunctional castor-oil based polyol. 4. The polyurethane composition of claim 1, wherein the calcium carbonate contributes to the generation of the porosity in the polyurethane composition. 5. The polyurethane composition of claim 1, wherein the water is present in an amount ranging from about 0.1% to about 1% by weight of the composition. 6. The polyurethane composition of claim 1, wherein the polyol is a naturally-occurring polyol, a biocompatible, synthetic polyol or both. 7. The polyurethane composition of claim 1, further comprising one or more of bone, calcium phosphate, calcium pyrophosphate, hydroxyapatite, poly methyl methacrylate, glass-ionomer, calcium sulfate, or tricalcium phosphate. 8. The polyurethane composition of claim 1, wherein the isocyanate is an aromatic isocyanate. 9. The polyurethane composition of claim 1, having a compressive strength of at least 50 MPa. 10. The polyurethane composition of claim 1, wherein the composition is initially in a moldable state and cures into a solid state. 11. The polyurethane composition of claim 1, wherein the composition cures into a solid state at room temperature about 20 minutes to about 30 minutes after formulation. 12. The polyurethane composition of claim 1, wherein the composition in its cured state has a tensile strength of at least 40 MPa. 13. The polyurethane composition of claim 1, wherein the composition in its cured state has a Modulus of Elasticity of at least 1,500 MPa. 14. The polyurethane composition of claim 1, wherein the calcium carbonate is present in an amount ranging from about 25% to about 35% by weight of the composition.