IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0690011
(2010-01-19)
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등록번호 |
US-8216558
(2012-07-10)
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발명자
/ 주소 |
- Van, Sang
- Tanaka, Yasunobu
- Yu, Lei
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출원인 / 주소 |
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대리인 / 주소 |
Knobbe Martens Olson & Bear LLP
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인용정보 |
피인용 횟수 :
0 인용 특허 :
23 |
초록
Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.
대표청구항
▼
1. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit selected from the group consisting of a recurring unit of the formula (IV), a recurring unit of the formula (V), and a recurring unit of the formula (VI): 2. A polymer-coated cell comprising a liv
1. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit selected from the group consisting of a recurring unit of the formula (IV), a recurring unit of the formula (V), and a recurring unit of the formula (VI): 2. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit represented by formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; wherein each W is an antibody, wherein the antibody is a receptor that is overexpressed in cancer cells; and wherein the polymer is non-covalently attached to the exterior of the living cell. 3. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit represented by formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; wherein each W is a fatty acid, wherein the fatty acid comprises a moiety selected from the group consisting of oleic, stearyl, palmitic, linoleic, linolenoic, and cholesteryl; and wherein the polymer is non-covalently attached to the exterior of the living cell. 4. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit represented by formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; wherein each W is a negatively charged group, wherein the negatively charged group is selected from the group consisting of C(═O)O−, SO3−, and PO42−; and wherein the polymer is non-covalently attached to the exterior of the living cell. 5. A method for coating a living cell, comprising intermixing the living cell with a polymer comprising at least one recurring unit selected from the group consisting of a recurring unit of the formula (IV), a recurring unit of the formula (V), and a recurring unit of the formula (VI): 6. A method for coating a living cell, comprising intermixing the living cell with a polymer comprising at least one recurring unit of formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; and wherein each W is a fatty acid, wherein the fatty acid comprises a moiety selected from the group consisting of oleic, stearyl, palmitic, linoleic, linolenoic, and cholesteryl. 7. A method for coating a living cell, comprising intermixing the living cell with a polymer comprising at least one recurring unit of formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; and wherein each W is a negatively charged group, wherein the negatively charged group is selected from the group consisting of C(═O)O−, SO3−, and PO42−. 8. A polymer-coated cell comprising a living cell and a polymer comprising at least one recurring unit represented by formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; wherein each W is biotin; and wherein the polymer is non-covalently attached to the exterior of the living cell. 9. A method for coating a living cell, comprising intermixing the living cell with a polymer comprising at least one recurring unit of formula (I): wherein each n is 1 or 2; wherein each Z is an optional linker group comprising from about zero to about 20 carbon atoms, from about zero to about 5 oxygen atoms, from about zero to about five nitrogen atoms, from about zero to about 5 sulfur atoms, and from about zero to about five phosphorous atoms; and wherein each W is biotin. 10. The polymer of claim 3, further comprising at least one second recurring unit represented by formula (I), wherein in the second recurring unit W is a negatively charged group selected from the group consisting of C(═O)O−, SO3−, and PO42; and at least one third recurring unit represented by formula (I), wherein in the third recurring unit W is biotin. 11. The polymer of claim 10, wherein the living cell is a mammalian cell. 12. The polymer of claim 10, wherein the living cell is a human cell.
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