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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0769172 (2010-04-28) |
등록번호 | US-8216612 (2012-07-10) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 310 |
Embolization, as well as related particles, compositions, and methods, are disclosed.
1. A particle comprising a first polymer, the particle having an interior region and a surface region, a weight percent of the first polymer in the interior region of the particle being less than a weight percent of the first polymer at the surface region of the particle, and the particle having a d
1. A particle comprising a first polymer, the particle having an interior region and a surface region, a weight percent of the first polymer in the interior region of the particle being less than a weight percent of the first polymer at the surface region of the particle, and the particle having a diameter of from about ten microns to about 3,000 microns, wherein the first polymer has the formula D-B-[O-(A-O)n-B]m-D, where O is a first oligomeric segment, B is a first coupling segment, A is a second coupling segment, D is a polyfluoro oligomeric group, m is from one to 20, and n is from zero to 20. 2. The particle of claim 1, wherein the interior region is devoid of the first polymer. 3. The particle of claim 1, wherein the interior region comprises at most 50 weight percent of the first polymer. 4. The particle of claim 3, wherein the particle comprises from about 0.1 weight percent to about 90 weight percent of the first polymer. 5. The particle of claim 1, wherein the interior region comprises at least 0.1 weight percent of the first polymer. 6. The particle of claim 1, wherein the surface region comprises at least 0.1 weight percent of the first polymer. 7. The particle of claim 6, wherein the particle comprises from about 0.1 weight percent to about 90 weight percent of the first polymer. 8. The particle of claim 1, wherein the surface region comprises at most 100 weight percent of the first polymer. 9. The particle of claim 1, wherein the difference between the weight percent of the first polymer in the interior region and the weight percent of the first polymer at the surface region is at least 30 weight percent. 10. The particle of claim 1, wherein the particle has a diameter of at least 100 microns. 11. The particle of claim 1, wherein the particle has a diameter of at most 2,500 microns. 12. The particle of claim 1, wherein the first polymer comprises a backbone and side groups that are more polar than the backbone. 13. The particle of claim 1, wherein the first polymer has a molecular weight of from about 500 to about 15,000. 14. The particle of claim 1, wherein the first polymer is linear. 15. The particle of claim 1, wherein O comprises a member selected from the group consisting of polyurethanes, polyureas, polyamides, polyalkylene oxides, polycarbonates, polyesters, polylactones, polysilicones, polyethersulfones, polyolefins, polyvinyls, polypeptide polysaccharides, and ether and amine linked segments thereof. 16. The particle of claim 1, wherein A comprises a member selected from the group consisting of diamines, diisocyanates, disulfonic acids, dicarboxylic acids, diacid chlorides, and dialdehydes. 17. The particle of claim 1, wherein B comprises a member selected from the group consisting of diamines, diisocyanates, disulfonic acids, dicarboxylic acids, diacid chlorides, and dialdehydes. 18. The particle of claim 17, wherein B further comprises a functional group selected from the group consisting of esters, carboxylic acid salts, sulfonic acid salts, phosphonic acid salts, thiols, vinyls, and secondary amines. 19. The particle of claim 1, wherein D comprises CF3(CF2)pCH2CH2—, wherein p is from two to 20. 20. The particle of claim 1, wherein D comprises CF3(CF2)m(CH2CH20)q-, wherein m is from one to 20 and q is from one to ten. 21. The particle of claim 1, wherein the particle further comprises a therapeutic agent. 22. The particle of claim 1, wherein the particle further comprises a therapeutic agent. 23. The particle of claim 1, wherein the particle further comprises a second polymer. 24. The particle of claim 23, wherein the second polymer comprises a member selected from the group consisting of polyvinyl alcohols, polyacrylic acids, polymethacrylic acids, poly vinyl sulfonates, carboxymethyl celluloses, hydroxyethyl celluloses, substituted celluloses, polyacrylamides, polyethylene glycols, polyamides, polyureas, polyurethanes, polyesters, polyethers, polystyrenes, polysaccharides, polylactic acids, polyethylenes, polymethylmethacrylates, polycaprolactones, polyglycolic acids, poly(lactic-co-glycolic) acids, and combinations thereof. 25. The particle of claim 23, wherein the particle further comprises a therapeutic agent. 26. The particle of claim 25, wherein the therapeutic agent is bound to the first polymer. 27. The particle of claim 1, wherein the particle further comprises a polysaccharide. 28. The particle of claim 1, wherein the particle is spherical. 29. The particle of claim 1, wherein the particle further comprises a coating disposed over the surface region. 30. The particle of claim 29, wherein the coating is bioabsorbable. 31. The particle of claim 1, wherein the particle comprises from about 0.25 weight percent to about 50 weight percent of the first polymer. 32. The particle of claim 1, wherein the particle comprises from about 15 weight percent to about 35 weight percent of the first polymer. 33. The particle of claim 1, wherein the interior region has a density of large pores and the surface region has a density of large pores, and the density of large pores of the interior region is greater than the density of large pores at the surface region.
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