Method of calibrating an analyte-measurement device, and associated methods, devices and systems
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/05
A61B-005/00
출원번호
US-0494197
(2009-06-29)
등록번호
US-8219174
(2012-07-10)
발명자
/ 주소
Feldman, Benjamin J.
McGarraugh, Geoffrey V.
출원인 / 주소
Abbott Diabetes Care Inc.
대리인 / 주소
Jackson & Co., LLP
인용정보
피인용 횟수 :
0인용 특허 :
340
초록▼
The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “of
The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.
대표청구항▼
1. An in vivo analyte sensor calibration system, comprising: an in vivo analyte sensor, at least a portion of the sensor subcutaneously positioned to generate one or more signals;a transmission element operatively coupled to the in vivo analyte sensor and configured to transmit one or more analyte-r
1. An in vivo analyte sensor calibration system, comprising: an in vivo analyte sensor, at least a portion of the sensor subcutaneously positioned to generate one or more signals;a transmission element operatively coupled to the in vivo analyte sensor and configured to transmit one or more analyte-related signals of the in vivo analyte sensor;a calibration sensor configured to be placed in contact with one or more blood samples from one or more off-finger calibration sites to provide one or more calibration measurements; anda data processing element configured to physically couple with the calibration sensor to communicate with the transmission element, the data processing element further configured to determine a quality of the one or more calibration measurements and a quality of the one or more generated signals from the in vivo analyte sensor, to convert the one or more generated signals from the in vivo analyte sensor into a corresponding one or more analyte concentration values based on the one or more calibration measurements if the quality of the one or more calibration measurements and the quality of the one or more generated signals from the in vivo analyte sensor are suitable for calibration, to determine an unweighted sensitivity associated with each of the one or more calibration measurements, to determine an adjusted sensitivity weighting factor associated with each of the one or more calibration measurements by multiplying a raw weighting factor by the corresponding unweighted sensitivity for each of the one or more calibration measurements and then further multiplying by a summation of each of the unweighted sensitivities raised to a power of the sensitivity weighting factor, and to determine a weighted sensitivity for each of the one or more calibration measurements based on the adjusted sensitivity factor associated with each of the one or more calibration measurements. 2. The system of claim 1, wherein the in vivo analyte sensor is a glucose sensor. 3. The system of claim 2, wherein the in vivo glucose sensor comprises a sensing element that comprises a glucose responsive enzyme. 4. The system of claim 3, wherein the sensing element comprises a hydrophilic portion. 5. The system of claim 1, wherein the data processing element comprises a hand-held display module. 6. The system of claim 1, wherein the data processing element is configured to evaluate whether the one or more calibration measurements are within a predetermined range of analyte concentration to determine the quality of the one or more calibration measurements. 7. The system of claim 6, wherein the predetermined range comprises about 60 mg/dL to about 350 mg/dL. 8. The system of claim 1, wherein the quality of the generated one or more signals from the in vivo analyte sensor comprises evaluating whether the one or more signals is within a predetermined rate of change of the one or more signals from the in vivo analyte sensor. 9. The system of claim 1, wherein the calibration sensor is an in vitro sensor. 10. The system of claim 1, wherein the calibration sensor is an in vivo calibration sensor. 11. The system of claim 1, wherein the in vivo analyte sensor is a transcutaneous sensor. 12. The system of claim 1, wherein the sensitivity is determined by taking the average of each of the one or more generated signals divided by a corresponding calibration measurement. 13. The system of claim 1, wherein the calibration device is configured to determine a temperature compensated analyte concentration value based at least in part on the one or more analyte concentration values and a temperature compensation factor. 14. The system of claim 13, wherein the calibration device is further configured to determine a lag compensated analyte concentration value by applying a lag factor to a change in the temperature compensated analyte value over a time period between two acceptable calibration points divided by the time period between the two acceptable calibration points added to the temperature compensated analyte value. 15. The system of claim 14, wherein the two acceptable calibration points are deemed acceptable based on at least one evaluation standard being met. 16. The system of claim 1, wherein the data processing unit is further configured to determine a temperature compensated glucose concentration by dividing at least one value of the one or more signals by the corresponding weighted sensitivity value and multiplying by a temperature compensation factor that is raised to a power equal to the difference in the temperature at a time associated with a calibration measurement and the temperature at the time associated with the generated one or more signals. 17. The system of claim 1, wherein the one or more processors is configured to evaluate that a temperature measurement is within a predetermined range of temperatures when determining the quality of the one or more calibration measurements. 18. The system of claim 1, wherein the one or more processors is configured to evaluate a quality of the calibration measurement by comparing the determined weighted sensitivity of the in vivo analyte sensor to a predetermined range. 19. The system of claim 13, wherein the one or more processors is configured to determine a lag corrected glucose concentration value by adding to the determined temperature compensated glucose concentration value a lag correction factor that is multiplied by a change in the temperature compensated glucose concentration value divided by a time period between two calibration measurements minus the temperature divided by the change in time between the two calibration measurements. 20. The system of claim 1, wherein determining the weighted sensitivity for each of the one or more calibration points includes dividing a summation of each of the adjusted sensitivity weighting factors each raised to a power equal to the corresponding unweighted sensitivity by a summation of each of the adjusted sensitivity weighting factors divided by a corresponding sensitivity offset factor.
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