System for embolizing a target site in a body by application of an external energy
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-029/00
출원번호
US-0873008
(2010-08-31)
등록번호
US-8226680
(2012-07-24)
발명자
/ 주소
Wallace, Michael P.
출원인 / 주소
Stryker Corporation
대리인 / 주소
Vista IP Law Group LLP
인용정보
피인용 횟수 :
7인용 특허 :
40
초록▼
A vaso-occlusive device is introduced in a cavity of a patient's vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or acti
A vaso-occlusive device is introduced in a cavity of a patient's vasculature, such as an aneurysm, after which an external energy source, such as a MRI machine is activated to heat the vaso-occlusive device to assist in forming a thrombus or embolism within the treatment site, to release and/or activate a diagnostic or therapeutic agent carried by the vaso-occlusive device, and/or to fuse together portions of the vaso-occlusive device to help stabilize the device in a three-dimensional shape.
대표청구항▼
1. A system for embolizing a target site in a vasculature of a body, comprising: a vaso-occlusive device detachably coupled to a distal end of a delivery wire insertable through a delivery catheter for deploying the vaso-occlusive device at a target site in a vasculature of a body, wherein the vaso-
1. A system for embolizing a target site in a vasculature of a body, comprising: a vaso-occlusive device detachably coupled to a distal end of a delivery wire insertable through a delivery catheter for deploying the vaso-occlusive device at a target site in a vasculature of a body, wherein the vaso-occlusive device is coated with a therapeutic bioactive agent, and additionally having a polymeric material coating substantially covering the bioactive agent coating; andan external energy emitting device configured to deliver energy from a location outside the body to thereby heat the vaso-occlusive device after the vaso-occlusive device has been deployed at the target site in the body, wherein, when heated by energy emitted from the external energy emitting device, the polymeric material coating at least partially melts or softens so that the bioactive agent is released or activated at the target site. 2. The system of claim 1, the target site comprising one of an aneurysm, a blood vessel lumen and a fistula. 3. The system of claim 1, the external energy emitting device comprising a magnetic resonance device. 4. The system of claim 3, wherein the vaso-occlusive device comprises a ferrous material in sufficient concentration to cause heating of the device in response to energy delivered by the magnetic resonance device. 5. The system of claim 1, wherein the external energy emitting device comprises an ultrasound device configured to be acoustically coupled to an exterior surface of the body. 6. The system of claim 1, wherein the external energy emitting device comprises a radio frequency energy generator. 7. A system for embolizing a target site in a body, comprising: a vaso-occlusive device detachably coupled to a distal end of a delivery wire insertable through a delivery catheter for deploying the vaso-occlusive device at a target site in a vasculature of a body, the vaso-occlusive device comprising a highly resistive element that is heated by application of a magnetic field, the vaso-occlusive device further comprising a polymeric material exterior coating and a therapeutic bioactive agent underlying the polymeric material coating; anda magnetic resonance imaging (“MRI”) device, wherein activating the MRI device to apply a variable magnetic field to the body after the vaso-occlusive device has been deployed at the target site heats the highly resistive element in the vaso-occlusive device, thereby at least partially melting or softening the polymeric material exterior coating on the vaso-occlusive device to release or activate the underlying therapeutic bioactive agent. 8. The system of claim 7, wherein the vaso-occlusive device may be sufficiently heated by application of magnetic field energy to cause coagulation of blood at the target site. 9. The system of claim 7, wherein the vaso-occlusive device is configured to assume a three-dimensional shape upon being deployed at the target site, and wherein the vaso-occlusive device may be sufficiently heated by application of magnetic field energy to at least partially melt and fuse together portions of the vaso-occlusive device to thereby stabilize the vaso-occlusive device in the three-dimensional shape. 10. A system for embolizing an aneurysm in a body, comprising: a vaso-occlusive device detachably coupled to a delivery catheter to thereby deploy the vaso-occlusive device in an aneurysm, the device including: a highly conductive coil forming a lumen; anda highly resistive element at least partially disposed in the coil lumen,wherein the coil is coated with a therapeutic bioactive agent, and additionallycoated with a polymeric material substantially covering the bioactive agent,such that applying magnetic field energy to the device from an energy emitting element located outside of the body would thereby heat the highly resistive element and, by way of convective heat transfer from the highly resistive element, heat the coil to thereby at least partially melt or soften the polymeric material coating to release or activate the bioactive agent. 11. The system of claim 10, the coil comprising platinum; the highly resistive element comprising ferrous material. 12. The system of claim 10, wherein the vaso-occlusive device may be sufficiently heated by application of energy from a source external to the body to cause coagulation of blood at the target site. 13. The system of claim 10, wherein the vaso-occlusive device is configured to assume a three-dimensional shape upon being deployed at the target site, and wherein the vaso-occlusive device may be sufficiently heated by application of energy from a source external to the body to at least partially melt and fuse together portions of the vaso-occlusive device to thereby stabilize the vaso-occlusive device in the three-dimensional shape.
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