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특허 상세정보

PDGF fusion proteins incorporated into fibrin foams

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-038/48   
미국특허분류(USC) 424/094.64; 424/094; 530/350
출원번호 US-0342420 (2008-12-23)
등록번호 US-8226942 (2012-07-24)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 7  인용 특허 : 52
초록

Compositions for wound healing, use of the compositions, and kits and methods of using thereof are described herein. In a preferred aspect, the compositions are suitable for use in a method for forming a fibrin matrix or foam that can be applied or injected at the site of need. In another preferred aspect, the compositions are also suitable for use in methods for forming enhanced controlled delivery fibrin matrices that can be administered as gels or foams.

대표
청구항

1. A foam composition comprising: fibrinogen;thrombin, wherein the amount of thrombin is less than 0.3 IU of thrombin/mg of fibrinogen;at least one fusion protein comprising a first domain comprising a platelet-derived growth factor (PDGF) and a second domain comprising a transglutaminase substrate domain;and a biocompatible gas selected from the group consisting of CO2, N2, air, and an inert gas, in an effective amount to form the foam. 2. The composition of claim 1, further comprising a calcium source. 3. The composition of claim 1, wherein the transgl...

이 특허에 인용된 특허 (52)

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