Systems and methods for replacing signal artifacts in a glucose sensor data stream
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/05
A61B-005/00
출원번호
US-0789153
(2010-05-27)
등록번호
US-8229536
(2012-07-24)
발명자
/ 주소
Goode, Jr., Paul V.
Brauker, James H.
Kamath, Apurv U.
Thrower, James Patrick
Carr-Brendel, Victoria
출원인 / 주소
DexCom, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
26인용 특허 :
335
초록▼
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have hi
Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.
대표청구항▼
1. A method for detecting an oxygen deficiency in a continuous glucose sensor, the method comprising: receiving sensor data generated by a continuous glucose sensor during a first time period, wherein the continuous glucose sensor is configured to measure a glucose concentration in a subcutaneous ti
1. A method for detecting an oxygen deficiency in a continuous glucose sensor, the method comprising: receiving sensor data generated by a continuous glucose sensor during a first time period, wherein the continuous glucose sensor is configured to measure a glucose concentration in a subcutaneous tissue of a host;identifying, using a processor module, an oxygen deficiency associated with the continuous glucose sensor based on an evaluation of the sensor data for the first time period; andprocessing the sensor data, using the processor module, responsive to the identification of the oxygen deficiency. 2. The method of claim 1, wherein the sensor data comprises data indicative of a signal response to at least one event selected from the group consisting of a switching of a voltage of a working electrode of the continuous glucose sensor, a cycling of a voltage of a working electrode of the continuous glucose sensor, and a pulsing of a voltage of a working electrode of the continuous glucose sensor. 3. The method of claim 2, wherein the evaluation of the sensor data for the first time period comprises an evaluation of the signal response. 4. The method of claim 3, wherein the evaluation of the signal response comprises determining an oxygen measurement. 5. The method of claim 1, wherein the evaluation of the sensor data for the first time period comprises evaluating sensor data generated by a counter electrode of the continuous glucose sensor or a reference electrode of the continuous glucose sensor. 6. The method of claim 1, wherein identifying the oxygen deficiency comprises determining a severity of the oxygen deficiency. 7. The method of claim 6, further comprising processing the sensor data based on the severity of the oxygen deficiency. 8. The method of claim 1, wherein processing the sensor data comprises suspending display of information representative of the sensor data. 9. The method of claim 1, wherein processing the sensor data comprises replacing sensor data for the first time period that is associated with the detected oxygen deficiency with estimated sensor data. 10. The method of claim 1, wherein identifying the oxygen deficiency comprises performing pulsed amperometric detection. 11. The method of claim 10, wherein the pulsed amperometric detection determines an oxygen measurement. 12. The method of claim 10, wherein performing pulsed amperometric detection includes switching, cycling, or pulsing the voltage of a working electrode or reference electrode of the continuous glucose sensor. 13. The method of claim 12, wherein the voltage is switched, cycled or pulsed between a positive voltage and a negative voltage. 14. The method of claim 13, wherein the positive voltage is +0.6V and the negative voltage is −0.6V. 15. The method of claim 1, wherein identifying the oxygen deficiency comprises monitoring a counter electrode of the continuous glucose sensor for an indication that insufficient oxygen is available for reduction. 16. The method of claim 15, wherein monitoring the counter electrode of the continuous glucose sensor for an indication that insufficient oxygen is available for reduction comprises determining if the counter electrode is at ground of 0.0V. 17. The method of claim 1, wherein identifying the oxygen deficiency comprises monitoring a drop off in sensor current as a function of glucose concentration. 18. The method of claim 1, wherein identifying the oxygen deficiency comprises determining that the working electrode is no longer oxidizing all H2O2 arriving at its surface because of a reduced bias voltage. 19. A method for detecting an oxygen deficiency in a continuous glucose sensor, the method comprising: receiving sensor data generated by a continuous glucose sensor during a first time period, wherein the continuous glucose sensor is configured to measure a glucose concentration in a subcutaneous tissue of a host;evaluating, using a processor module, the sensor data for the first time period; anddetecting, using the processor module, signal artifacts associated with an oxygen deficiency based on the evaluation of the sensor data for the first time period;wherein evaluating the sensor data for the first time period comprises evaluating a frequency content of the sensor data, and wherein evaluating the frequency content comprises performing an orthogonal transform. 20. A system for detecting oxygen deficiencies in a continuous glucose sensor, the system comprising: a continuous glucose sensor configured to produce sensor data during a first time period, wherein the continuous glucose sensor is configured to measure a glucose concentration in a subcutaneous tissue of a host; anda processor module configured to identify an oxygen deficiency associated with the continuous glucose sensor based on an evaluation of the sensor data for the first time period and process the sensor data responsive to the identification of the oxygen deficiency. 21. The system of claim 20, wherein the processor module is configured to determine a severity of the oxygen deficiency. 22. The method of claim 21, wherein the processor module is configured to process the sensor data based on the severity of the oxygen deficiency. 23. The system of claim 20, wherein processing the sensor data comprises suspending display of information representative oaf the sensor data. 24. The system of claim 20, wherein processing the sensor data comprises replacing sensor data for the first time period that is associated with the detected oxygen deficiency with estimated sensor data. 25. The system of claim 20, wherein the processor module is configured to initiate pulsed amperometric detection using the continuous glucose sensor, and wherein identifying the oxygen deficiency comprises evaluating a response of the pulsed amperometric detection. 26. The system of claim 25, wherein evaluating the response of the pulsed amperometric detection the pulsed amperometric detection includes determining an oxygen measurement based on the response. 27. The system of claim 25, wherein the pulsed amperometric detection includes switching, cycling, or pulsing the voltage of a working electrode or reference electrode of the continuous glucose sensor. 28. The system of claim 27, wherein the voltage is switched, cycled or pulsed between a positive voltage and a negative voltage. 29. The system of claim 28, wherein the positive voltage is +0.6V and the negative voltage is −0.6V. 30. The system of claim 20, wherein identifying the oxygen deficiency comprises monitoring a signal response of a counter electrode of the continuous glucose sensor for an indication that insufficient oxygen is available for reduction. 31. The system of claim 30, wherein the monitoring comprises determining if the counter electrode is at ground or 0.0V. 32. The system of claim 20, wherein identifying the oxygen deficiency comprises monitoring a drop off in sensor current as a function of glucose concentration. 33. The system of claim 20, wherein identifying the oxygen deficiency comprises determining that the working electrode is no longer oxidizing all H2O2 arriving at its surface because of a reduced bias voltage. 34. A method for detecting an oxygen deficiency in a continuous glucose sensor, the method comprising: receiving sensor data generated by a continuous glucose sensor during a first time period, wherein the continuous glucose sensor is configured to measure a glucose concentration in a subcutaneous tissue of a host;identifying, using a processor module, an oxygen deficiency associated with the continuous glucose sensor, wherein the identifying comprises monitoring a counter electrode of the continuous glucose sensor for an indication that insufficient oxygen is available; andprocessing the sensor data, using the processor module, responsive to the identification of the oxygen deficiency. 35. The method of claim 34, wherein monitoring the counter electrode of the continuous glucose sensor for an indication that insufficient oxygen is available for reduction comprises determining if the counter electrode is at ground or 0.0V. 36. The method of claim 34, wherein processing the sensor data comprises suspending display of information representative of the sensor data. 37. The method of claim 34, wherein processing the sensor data comprises replacing sensor data for the first time period that is associated with the detected oxygen deficiency with estimated sensor data.
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Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
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Kamath, Apurv Ullas; Brauker, James H.; Mahalingam, Aarthi; Li, Ying, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
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