Device and method for delivering micronized therapeutic agents in the body
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-031/00
출원번호
US-0022217
(2011-02-07)
등록번호
US-8235937
(2012-08-07)
발명자
/ 주소
Palasis, Maria
Naimark, Wendy
Freyman, Toby
Epstein, Samuel
출원인 / 주소
Boston Scientific Scimed, Inc.
대리인 / 주소
Vidas, Arrett & Steinkraus, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
14
초록▼
The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also
The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
대표청구항▼
1. A catheter assembly comprising: a catheter having a lumen extending therethrough, a proximal end, and a distal end including a nozzle, the catheter including:a therapeutic agent reservoir;a pressurization chamber located between the therapeutic agent reservoir and the nozzle;a loading valve posit
1. A catheter assembly comprising: a catheter having a lumen extending therethrough, a proximal end, and a distal end including a nozzle, the catheter including:a therapeutic agent reservoir;a pressurization chamber located between the therapeutic agent reservoir and the nozzle;a loading valve positioned between the therapeutic agent reservoir and the pressurization chamber;an injection valve positioned between the pressurization chamber and the nozzle; anda pressurized gas delivery tube having a first end and a second end, the first end connected to a pressurized gas source and the second end in fluid communication with the pressurization chamber of the catheter. 2. The catheter of claim 1, wherein the therapeutic agent reservoir is a cassette filled with therapeutic agents. 3. The catheter assembly of claim 1, wherein the pressurized gas delivery tube is located in the lumen of the catheter. 4. The catheter assembly of claim 1, wherein the injection valve and the loading valve comprise valve stems. 5. The catheter assembly of claim 4, wherein the injection valve and loading valve further comprise a hollow member, an axially elongated pin, and a seal, the seal covering the valve stem. 6. The catheter assembly of claim 1 further comprising a pressurized gas, the pressurized gas consisting of: helium, nitrogen, air, or hydrogen. 7. The catheter assembly of claim 1 further comprising a pressure gauge, the pressure gauge configured to measure the in the pressurization chamber. 8. The catheter assembly of claim 1 further comprising at least one therapeutic agent disposed within the therapeutic agent reservoir. 9. The catheter assembly of claim 8, wherein the therapeutic agent consists of one or more: pharmaceutically active compounds, nucleic acids, compacting agents, viruses, polymers, hyaluronic acid, proteins, and cells. 10. The catheter assembly of claim 8, wherein the therapeutic agent is microencapsulated with polymeric material to form a polymeric material/therapeutic agent matrix. 11. A catheter assembly for delivering micronized therapeutic agents to the heart, the catheter assembly comprising: a catheter having a nozzle at the distal end thereof, the catheter comprising: a therapeutic agent reservoir containing a therapeutic agent;a pressurization chamber located between the therapeutic agent reservoir and the nozzle, the pressurization chamber comprising a micro-cylinder filled with a gas;a loading valve positioned between the therapeutic agent reservoir and the pressurization chamber; andan injection valve positioned between the pressurization chamber and the nozzle.
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이 특허에 인용된 특허 (14)
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Sanford John C. (Geneva) DeVit Michael J. (Geneva NY) Bruner Ronald F. (Sewell NJ) Johnston Stephen A. (Durham NC), Method and apparatus for introducing biological substances into living cells.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
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