IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0915289
(2010-10-29)
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등록번호 |
US-8241229
(2012-08-14)
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발명자
/ 주소 |
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출원인 / 주소 |
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인용정보 |
피인용 횟수 :
1 인용 특허 :
25 |
초록
▼
The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected t
The present invention relates to methods and devices for formation of microconduits in tissue, particularly using an impedance sensing drill to form microconduits. One embodiment of the invention is an impedance sensing drill comprising a drilling assembly, a control module, mechanically connected to the drilling assembly for controlling the depth of drilling by the drilling assembly; and a sensor, electrically connected to the drilling assembly and control module for detecting a change in an electrical impedance of a material being drilled. Another embodiment is a method of forming a microconduit in a material, which comprises the steps of drilling into the material, monitoring an electrical impedance of the material, and stopping the drilling into the material when a change in the impedance is detected, thereby forming microconduit.
대표청구항
▼
1. A method of removing an analyte, which comprises the steps of: painlessly drilling into a target area with a drilling assembly, monitoring an electrical impedance of the target area, stopping the drilling into the target area when a change in the electrical impedance is detected, thereby forming
1. A method of removing an analyte, which comprises the steps of: painlessly drilling into a target area with a drilling assembly, monitoring an electrical impedance of the target area, stopping the drilling into the target area when a change in the electrical impedance is detected, thereby forming a microconduit, and removing the analyte via the formed microconduit; wherein the drilling assembly includes a motor, an impedance sensor, and a cutter, and wherein the drilling into the tissue is stopped and automatically reversed by a control module when a change in the electrical impedance of the target area is detected by the sensor. 2. The method of claim 1, wherein the electrical impedance being measured is electrical resistance. 3. The method of claim 1, wherein the impedance sensing drill is computer controlled. 4. The method of claim 1, wherein the drilling assembly further comprises a housing adapted to be placed in contact with a tissue being drilled; a motor and a cutter rotated by the motor which is mobile in translation in the housing and which is adapted to be moved into and out of the tissue being drilled for the formation of microconduits; a control module mechanically connected to the drilling assembly for controlling the translation of the cutter in the housing and into and out of the tissue being drilled; and a sensor, electrically connected to the drilling assembly and to the control module for detecting a change in an electrical impedance between the cutter and the surface of the tissue being drilled when the cutter is translated in the tissue being drilled; wherein the sensor, upon detection of a change in the electrical impedance corresponding to a transition between portions of the material being drilled, sends a signal to the control module to automatically reverse the direction of the cutter, thereby withdrawing the cutter from the tissue being drilled, and thereby controlling the depth of the drilling. 5. A method of removing the stratum corneum from the epidermis to permit extraction of analyte from the body, which comprises the steps of: drilling into a target area with a drilling assembly, monitoring an electrical impedance of the target area, stopping the drilling into the target area when a change in the electrical impedance is detected, thereby forming a microconduit, and extracting analyte from the body through the microconduit; wherein the drilling assembly includes a motor, an impedance sensor, and a cutter, and wherein the drilling into the tissue is stopped and automatically reversed by a control module when a change in the electrical impedance of the target area is detected by the sensor. 6. The method of claim 5, wherein the analyte is a blood sample. 7. The method of claim 5, wherein the analyte is a tissue sample. 8. The method of claim 5, wherein the analyte an interstitial fluid sample. 9. The method of claim 5, wherein the electrical impedance being measured is electrical resistance. 10. The method of claim 5, wherein the impedance sensing drill is computer controlled. 11. The method of claim 5, wherein the drilling assembly further comprises a housing adapted to be placed in contact with a tissue being drilled; a motor and a cutter rotated by the motor which is mobile in translation in the housing and which is adapted to be moved into and out of the tissue being drilled for the formation of microconduits; a control module mechanically connected to the drilling assembly for controlling the translation of the cutter in the housing and into and out of the tissue being drilled; and a sensor, electrically connected to the drilling assembly and to the control module for detecting a change in an electrical impedance between the cutter and the surface of the tissue being drilled when the cutter is translated in the tissue being drilled; wherein the sensor, upon detection of a change in the electrical impedance corresponding to a transition between portions of the material being drilled, sends a signal to the control module to automatically reverse the direction of the cutter, thereby withdrawing the cutter from the tissue being drilled, and thereby controlling the depth of the drilling. 12. A method of removing the stratum corneum from the epidermis to permit blood collection from the body for analysis, which comprises the steps of drilling into a target area with a drilling assembly, monitoring an electrical impedance of the target area, stopping the drilling into the target area when a change in the electrical impedance is detected, thereby forming a microconduit, and removing blood from the body through the microconduit; wherein the drilling assembly includes a motor, an impedance sensor, and a cutter, and wherein the drilling into the tissue is stopped and automatically reversed by a control module when a change in the electrical impedance of the target area is detected by the sensor. 13. The method of claim 12, wherein the electrical impedance being measured is electrical resistance. 14. The method of claim 12, wherein the impedance sensing drill is computer controlled. 15. The method of claim 12, wherein the drilling assembly further comprises a housing adapted to be placed in contact with a tissue being drilled; a motor and a cutter rotated by the motor which is mobile in translation in the housing and which is adapted to be moved into and out of the tissue being drilled for the formation of microconduits; a control module mechanically connected to the drilling assembly for controlling the translation of the cutter in the housing and into and out of the tissue being drilled; and a sensor, electrically connected to the drilling assembly and to the control module for detecting a change in an electrical impedance between the cutter and the surface of the tissue being drilled when the cutter is translated in the tissue being drilled; wherein the sensor, upon detection of a change in the electrical impedance corresponding to a transition between portions of the material being drilled, sends a signal to the control module to automatically reverse the direction of the cutter, thereby withdrawing the cutter from the tissue being drilled, and thereby controlling the depth of the drilling.
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