IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0494092
(2009-06-29)
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등록번호 |
US-8246609
(2012-08-21)
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발명자
/ 주소 |
- Zickler, Leander
- Catlin, Scott J.
- Pang, Andrew Y
|
출원인 / 주소 |
|
대리인 / 주소 |
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인용정보 |
피인용 횟수 :
26 인용 특허 :
8 |
초록
▼
Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct
Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue. The system includes a laser assembly outputting a pulsed laser beam, and a controller coupled to the laser assembly. The controller directs the laser assembly to incise a corneal tissue inlay from a donor cornea, form a recipient bed in the recipient cornea having a contour matching the contour of the inlay, register the inlay with the recipient bed, determine a position of the inlay, and determine a position change for the inlay based on the position of the inlay to align the refractive profile of the inlay with the refractive profile of the eye.
대표청구항
▼
1. A method of modifying a refractive profile associated with an eye having a recipient cornea, the method comprising the steps of: obtaining a corneal tissue inlay from a donor cornea, the corneal tissue inlay having a refractive profile, the obtaining step comprising: incising a portion of the don
1. A method of modifying a refractive profile associated with an eye having a recipient cornea, the method comprising the steps of: obtaining a corneal tissue inlay from a donor cornea, the corneal tissue inlay having a refractive profile, the obtaining step comprising: incising a portion of the donor cornea with a femtosecond laser, the portion having an anterior surface and a posterior surface, wherein the incising step comprises one of a group consisting of: incising one or more lenticules from the donor cornea with the femtosecond laser, the one or more lenticules selected from a group consisting of a biconvex lenticule, a plano-convex lenticule, a meniscus lenticule, and a ring-shaped lenticule;incising a sub-surface portion having a polygonal cross-section from the donor cornea with the femtosecond laser; andincising a sub-surface portion from the donor cornea with the femtosecond laser, the sub-surface portion having a perimeter selected from a group consisting of a round perimeter, an oval perimeter, and a polygonal perimeter;removing the sub-surface portion from the donor cornea; andsculpting at least one of the anterior surface and the posterior surface in conformance with the refractive profile of the corneal tissue inlay;forming a recipient bed in the recipient cornea; andpositioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue inlay. 2. The method of claim 1, further comprising determining the refractive profile for the corneal tissue inlay based on the refractive profile of the eye prior to the step of positioning. 3. The method of claim 1, wherein the step of sculpting comprises photoaltering at least one of the anterior surface and the posterior surface with one of a femtosecond laser and an excimer laser. 4. The method of claim 1, wherein the step of incising comprises incising a lenticule from the donor cornea with the femtosecond laser. 5. The method of claim 1, wherein the step of obtaining further comprises incising an edge on the sub-surface portion, the edge configured to biomechanically stabilize a position of the corneal tissue inlay in the recipient bed. 6. The method of claim 1, wherein the step of forming comprises: incising a pocket in the recipient cornea, the recipient cornea having a surface, the pocket having the recipient bed and configured to receive the corneal tissue inlay; andincising a passage from the surface of the recipient cornea to the pocket. 7. The method of claim 1, wherein the eye has an optical axis, and wherein the step of forming comprises: forming the corneal tissue inlay and a recipient bed with matching contours;registering the corneal tissue inlay with the recipient bed to align the corneal tissue inlay with the optical axis and stabilize the corneal tissue inlay in the recipient bed;determining a position of the corneal tissue inlay;iteratively modifying the position of the corneal tissue inlay to align the refractive profile of the corneal tissue inlay with the refractive profile of the eye. 8. The method of claim 7, wherein the corneal tissue inlay has an orientation marker, and wherein the step of registering comprises: matching a contour of the corneal tissue inlay with a contour of the recipient bed; andaligning the orientation marker with a feature of the eye. 9. The method of claim 8, wherein the step of aligning comprises aligning the orientation marker with one or more of a pupil center position, an iris center position, and an iris structure. 10. The method of claim 1, further comprising orienting the corneal tissue inlay within the recipient bed based on at least one of an iris registration, a pupil-based centration, and pupil dynamics after the step of inserting. 11. The method of claim 1, wherein the step of obtaining comprises: removing the corneal tissue inlay from the donor cornea, the corneal tissue inlay having a surface;applying a non-stick film to the surface of the corneal tissue inlay; andcollapsing the corneal tissue inlay. 12. The method of claim 1, further comprising photoaltering the recipient cornea with an excimer laser after the step of inserting. 13. The method of claim 1, wherein the corneal tissue inlay is a multifocal lenticule, and wherein the method further comprises altering a shape of the recipient cornea with the multifocal lenticule. 14. The method of claim 1, wherein the donor cornea is a cadaver cornea. 15. A system for modifying a refractive profile associated with an eye having a recipient cornea, the system comprising: a laser assembly operable to output a pulsed laser beam; anda controller coupled to the laser assembly and operable to direct the laser assembly to:incise a corneal tissue inlay from a donor cornea, the corneal tissue inlay having a refractive profile correcting for the refractive profile of the eye and having a contour;form a recipient bed in the recipient cornea, the recipient bed having a contour matching the contour of the corneal tissue inlay;register the corneal tissue inlay with the recipient bed;determine a position of the corneal tissue inlay; anddetermine a position change for the corneal tissue inlay based on the position of the corneal tissue inlay to align the refractive profile of the corneal tissue inlay with the refractive profile of the eye;wherein the controller is further configured to perform one of a group consisting of: direct the laser assembly to incise one or more lenticules from the donor cornea, the one or more lenticules having the refractive profile of the corneal tissue inlay and selected from a group consisting of a biconvex lenticule, a piano-convex lenticule, a meniscus lenticule, and a ring-shaped lenticule;direct the laser assembly to incise a sub-surface portion having a polygonal cross-section from the donor cornea, the sub-surface portion having the refractive profile of the corneal tissue inlay;direct the laser assembly to incise a sub-surface portion having a perimeter from the donor cornea, the sub-surface portion having the refractive profile of the corneal tissue inlay, the perimeter selected from a group consisting of a round perimeter, an oval perimeter, and a polygonal perimeter; anddirect the laser assembly to incise an edge on the sub-surface portion, the edge configured to biomechanically stabilize a position of the corneal tissue inlay in the recipient bed. 16. The system of claim 15, wherein the controller is further configured to direct the laser assembly to: incise a portion of the donor cornea, the portion having an anterior surface and a posterior surface; andsculpt at least one of the anterior surface and the posterior surface in conformance with the refractive profile of the corneal tissue inlay. 17. The system of claim 15, wherein the controller is further configured to direct the laser assembly to: incise a pocket in the recipient cornea, the recipient cornea having a surface, the pocket having the recipient bed and configured to receive the corneal tissue inlay; andincise a passage from the surface of the recipient cornea to the pocket. 18. The system of claim 15, wherein the eye has an optical axis, and wherein the controller is further configured to align the corneal tissue inlay with the optical axis and stabilize the corneal tissue inlay in the recipient bed by registering the corneal tissue inlay with the recipient bed. 19. The system of claim 15, wherein the corneal tissue inlay has an orientation marker, and wherein the controller is further configured to determine an alignment of the orientation marker with one or more of a pupil center position, an iris center position, and an iris structure.
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