IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0102465
(2005-04-08)
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등록번호 |
US-8246974
(2012-08-21)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
Pauly, Devries Smith & Deffner, L.L.C.
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인용정보 |
피인용 횟수 :
6 인용 특허 :
158 |
초록
▼
Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical d
Embodiments of the invention include coated medical devices that can elute one or more bioactive agents within the body, and methods for producing the same. In an embodiment, the invention includes a method of forming a coated medical device including depositing a coated composition onto a medical device having a roughened segment and a smooth segment. In an embodiment, the invention includes a method of forming a coated implantable medical device including depositing a coated composition onto a medical device having a body segment and a piercing segment. In an embodiment, the invention includes a medical device, a coated composition provided on the substrate surface, the composition including a bioactive agent and a polymer. The medical device includes an uncoated component wherein the edge of the coated composition is within 0.5 mm of the uncoated component. In an embodiment, the invention includes a method for disposing a coated composition on a medical device with an ultrasonically atomized spray stream including moving a spray stream in a pattern having a plurality of transverse sweeps and a plurality of longitudinal movements.
대표청구항
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1. A medical device comprising: a substrate having a surface;a coating composition provided on the substrate surface, the coating composition comprising a bioactive agent and a polymer; andan uncoated component-comprising a piercing segment;wherein the coating composition is within 0.5 mm of the unc
1. A medical device comprising: a substrate having a surface;a coating composition provided on the substrate surface, the coating composition comprising a bioactive agent and a polymer; andan uncoated component-comprising a piercing segment;wherein the coating composition is within 0.5 mm of the uncoated component without extending onto the piercing segment. 2. The medical device of claim 1, wherein the polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate. 3. The medical device of claim 2, wherein the polymer comprises poly(n-butyl)methacrylate. 4. The medical device of claim 1, the coating composition further comprising poly(ethylene-co-vinyl acetate). 5. The medical device of claim 1, wherein the bioactive agent is selected from the group consisting of triamcinolone acetonide, 13-cis retinoic acid, 5-fluorouridine, and combinations thereof. 6. A medical device comprising: a substrate having a surface and a piercing segment; a first coating composition having an edge provided on the substrate surface, the first coating composition comprising a first bioactive agent and a first polymer; a second coating composition having an edge provided on the substrate surface, the second coating composition comprising a second bioactive agent and a second polymer; wherein the first coating composition and the second coating composition do not overlap; wherein the first coating composition edge is within 0.5 mm of the piercing segment, wherein neither the first coating or the second coating is disposed on the piercing segment. 7. The medical device of claim 6, wherein the first coating composition is configured to release the first bioactive agent more quickly than the second coating composition releases the second bioactive agent. 8. The medical device of claim 6, wherein the first polymer, the second polymer, or both the first and second polymers, comprise polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate. 9. The medical device of claim 6, wherein the first polymer, the second polymer, or both the first and second polymers, comprise poly(n-butyl)methacrylate. 10. The medical device of claim 6, wherein the first polymer, the second polymer, or both the first and second polymers, comprise poly(ethylene-co-vinyl acetate). 11. The medical device of claim 6, wherein the first bioactive agent, the second bioactive agent, or both the first and second bioactive agents, are selected from the group consisting of triamcinolone acetonide, 13-cis retinoic acid, 5-fluorouridine, and combinations thereof. 12. The medical device of claim 1, wherein the edge of the coating composition is between 0.1 mm and 0.5 mm away from the uncoated component. 13. The medical device of claim 1, wherein the uncoated component is a cap. 14. An implantable medical device for intraocular delivery comprising: a substrate comprising a surface comprising a roughened segment and a smooth segment;a coating composition disposed on the roughened segment, the coating composition comprising a bioactive agent and a polymer; andthe smooth segment comprising a piercing segment;wherein the coating composition is not disposed on the piercing segment. 15. The medical device of claim 14, the roughened segment having an Rz of greater than 4.0 μm. 16. The medical device of claim 14, the smooth segment having an Rz of less than 4.0 μm. 17. The medical device of claim 14, the coating composition comprising an edge adjacent to the smooth segment, the edge having a slope of less than 1.0. 18. The medical device of claim 17, the edge having a slope of less than 0.8.
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