IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0866283
(2007-10-02)
|
등록번호 |
US-8251055
(2012-08-28)
|
발명자
/ 주소 |
- Srinivasan, Sudarsan
- Ammann, David
- Brookman, Donald
- Maharajh, Niranjan
- Grollimund, Gary
- Sprinkel, Jr., F. Murphy
- McRae, Douglas D.
|
출원인 / 주소 |
|
대리인 / 주소 |
Buchanan Ingersoll & Rooney PC
|
인용정보 |
피인용 횟수 :
1 인용 특허 :
11 |
초록
▼
A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid f
A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially volatilized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation gas to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air or ventilation gas and direct the mixed aerosol into the inlet end of the flow passage.
대표청구항
▼
1. A drug delivery system, comprising: an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, (ii) at least one heater body operable to heat the capillary passage to a temperature range effective to at least partially volatilize th
1. A drug delivery system, comprising: an aerosol generator unit comprising (i) a capillary passage adapted to at least partially volatilize a liquid formulation, (ii) at least one heater body operable to heat the capillary passage to a temperature range effective to at least partially volatilize the liquid formulation in the capillary passage, the capillary passage being fitted within the heater body, and (iii) at least one gas passage contained within the heater body and arranged such that gas is heated by the heater body to produce a heated gas;a pumping unit adapted to supply a liquid formulation to the aerosol generator unit;a flow passage having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface which supplies ventilation to a patient's lungs;an aerosol transition adapter arranged to mix aerosol produced by the capillary passage with the heated gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and operable to direct the mixed aerosol into the inlet end of the flow passage; anda control system operable to activate the aerosol generator unit and the pumping unit,wherein the control system is arranged to control temperatures for heating the liquid formulation and the gas, flow rates of the gas and aerosol, and mixing of aerosol with the heated gas in a manner that reduces condensation of aerosol to produce a mixed aerosol. 2. The drug delivery system of claim 1, wherein the pumping unit includes one syringe pump and a pair of valves operable to supply liquid formulation into an inlet of the aerosol generator unit. 3. The drug delivery system of claim 1, wherein the pumping unit includes two syringe pumps and a valving arrangement operable to supply liquid formulation into an inlet of one syringe pump during delivery of liquid formulation to the aerosol generator unit by the other syringe pump. 4. The drug delivery system of claim 3, wherein the valving arrangement includes an inlet which can be connected to a source of a liquid formulation, first and second flow paths in fluid communication with the inlet, an outlet in fluid communication with an inlet of the aerosol generator unit, first and second valves along the first flow path and third and fourth valves along the second flow path, the valves arranged such that the first flow path supplies liquid formulation to the first syringe pump when the first valve is open and the second valve is closed, the second flow path supplies liquid formulation to the second syringe pump when the third valve is open and the fourth valve is closed, the first flow path supplying liquid formulation to the aerosol generator unit when the first valve is closed and the second valve is open, and the second flow path supplying liquid formulation to the aerosol generator unit when the third valve is closed and the fourth valve is open. 5. The drug delivery system of claim 4, further comprising a control system operable to activate the aerosol generator unit and the pumping unit, the control system effecting initial filling of the syringe pumps via retraction of a first piston of the first syringe pump and a second of the second syringe pump while maintaining the first and third valves open and the second and fourth valves closed, delivering liquid formulation to the aerosol generator unit via advancement of the first piston while maintaining the first and fourth valves closed, activating the second syringe pump near the end of a delivery cycle of the first syringe pump via advancement of the second piston while maintaining the fourth valve open and the third valve closed, refilling the first syringe pump via retraction of the first piston while maintaining the first valve open and the second valve closed, activating the first syringe pump near the end of the delivery cycle of the second syringe pump via advancement of the first piston while maintaining the a second valve open and the first valve closed. 6. The drug delivery system of claim 1, wherein the capillary passage is a capillary tube adapted to fit within the heater body, and wherein the at least one gas passage is a tubular member adapted to fit with a sheath gas subassembly arranged such that the gas is heated by the sheath gas subassembly. 7. The drug delivery system of claim 1, wherein the aerosol transition adapter includes at least one baffle therein and/or a drainage port at a lower end thereof adapted to attach to a condensate collection device. 8. The drug delivery system of claim 1, wherein the pumping unit and aerosol generator unit includes disposable parts and reusable parts, the disposable parts including a capillary flow tube through which the liquid formulation is ejected as an aerosol and wetted parts of the pumping unit, the wetted parts including a screening member operable to trap particles in the liquid formulation above a predetermined size, the screening member located upstream of an inlet to the aerosol generator unit. 9. The drug delivery system of claim 1, further comprising a source of liquid formulation containing a lung surfactant adapted for delivery as an aerosol to an infant's lungs. 10. The drug delivery system of claim 1, further comprising a source of pressurized gas connected to the aerosol transition adapter, the source of pressurized gas supplying gas at a flow rate of about 1 to 6 L/min (liters per minute). 11. The drug delivery system of claim 1, wherein the aerosol generator unit is a disposable assembly, the disposable assembly comprising: a capillary tube adapted to form an aerosol when a liquid formulation in the capillary tube is heated to volatilize at least some of the liquid formulation therein;a syringe assembly comprised of a syringe pump and a pair of valves operable to supply the liquid formulation into an inlet of the capillary tube;a sheath gas tube subassembly comprised of a sheath gas tube operable to receive a ventilated or hospital gas supply; andthe aerosol transition adapter. 12. The drug delivery system of claim 11, wherein the sheath gas tube subassembly includes a sheath gas tube and a turbine assembly, wherein the turbine assembly controls the flow of ventilated or hospital gas to the aerosol transition adapter. 13. The drug delivery system of claim 11, further comprising a disposable assembly housing adapted to receive the disposable assembly, the disposable assembly housing comprising: a heater body, the heater body comprising: a lower heater subassembly having a channel adapted to receive the capillary tube and at least one heating unit positioned longitudinally within the lower heater subassembly;an upper heater subassembly,a lower sheath gas subassembly having a channel operable to receive the sheath gas tube and at least one heating unit positioned within the lower sheath gas subassembly; andan upper sheath gas subassembly. 14. The drug delivery system of claim 13, wherein the disposable assembly housing further includes a syringe pump operable to the supply the liquid formulation into the inlet of the capillary tube. 15. The drug delivery system of claim 1, wherein the aerosol generator unit is capable of delivering an aerosol with a drug concentration of 2.3 milligrams per liter of gas from a liquid formulation with a drug concentration of 10 milligrams per milliliter (mg/ml) and commensurately higher aerosol concentrations from formulations with higher concentrations. 16. A disposable assembly operable to produce an aerosol, the disposable assembly comprising: a heater having a heater body;a capillary tube fitted within the heater body and adapted to form an aerosol when a liquid formulation in the capillary tube is heated by the heater to volatilize at least some of the liquid formulation therein;a sheath gas passage contained within the heater body and operable to receive a ventilated or hospital gas;an aerosol transition adapter arranged to mix aerosol produced by the capillary tube with sheath gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and to direct the mixed aerosol into the inlet end of a flow passage; anda control system operable to activate the aerosol generator unit,wherein the control system is arranged to control temperatures for heating the liquid formulation and the sheath gas, flow rates of the sheath gas and aerosol, and mixing of aerosol with the heated sheath gas in a manner that reduces condensation of aerosol to produce a mixed aerosol. 17. The assembly of claim 16, further comprising at least one condensate collector adapted to collect condensed liquid or liquid produced by the capillary tube. 18. The assembly of claim 16, wherein the heater comprises a heater block in thermal contact with the capillary tube and adapted to receive the capillary tube, the heater block comprising: an upper assembly and a lower assembly, which encases the capillary tube;at least one heater cartridge positioned longitudinally within the upper assembly and the lower assembly; andat least one thermocouple incorporated in the heater block. 19. The assembly of claim 16, wherein the sheath gas passage includes a sheath gas tube and a turbine assembly, and wherein the turbine assembly controls the flow of gas from the ventilated or hospital gas supply to the aerosol transition adapter. 20. A base unit for generating aerosol, the base unit comprising: a disposable assembly having an aerosol generator unit therein;a disposable assembly housing adapted to receive the disposable assembly;a syringe pump operable to supply a liquid formulation to the aerosol generator unit;a heater having a heater body;a capillary tube fitted within the heater body and adapted to form an aerosol when the liquid formulation in the capillary tube is heated by the heater to volatilize at least some of the liquid formulation therein;a sheath gas passage contained within the heater body and operable to receive a ventilated or hospital gas;an aerosol transition adapter arranged to mix aerosol produced by the capillary tube with sheath gas in a manner that reduces condensation of aerosol to produce a mixed aerosol and to direct the mixed aerosol into the inlet end of a flow passage; anda control system operable to activate the aerosol generator unit and the syringe pump, such that the liquid formulation is at least partially volatilized to form an aerosol,wherein the control system is arranged to control temperatures for heating the liquid formulation and the sheath gas, flow rates of sheath gas and aerosol, and mixing of aerosol with the heated sheath gas in a manner that reduces condensation of aerosol to produce a mixed aerosol. 21. The base unit of claim 20, wherein the disposable assembly housing further includes a heater body comprising: a lower heater subassembly having a channel adapted to receive a capillary tube and at least one heating unit positioned longitudinally within the lower heater subassembly;an upper heater subassembly,a lower sheath gas subassembly having a channel operable to receive a sheath gas tube and at least one heating unit positioned within the lower sheath gas subassembly; andan upper sheath gas subassembly.
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