The present invention provides a substantially clear gel designed to reduce itching discomfort when applied to the vulvar tissue. The gel includes at least one anesthetic, protectant, emulsifier, and pH modifier, such as a base. The gel has a pH adapted to vulvar use and may be applied to the vulvar
The present invention provides a substantially clear gel designed to reduce itching discomfort when applied to the vulvar tissue. The gel includes at least one anesthetic, protectant, emulsifier, and pH modifier, such as a base. The gel has a pH adapted to vulvar use and may be applied to the vulvar tissues.
대표청구항▼
1. An anti-itch gel, for treating itching of the vulvar tissues, comprising: 20-60% by weight water,a water-soluble salt of pramoxine,a pH modifier,from 5 to 60% by weight of a protectant, anda water-in-oil emulsifier comprising one or more silicones, where the gel has a turbidity of less than 100 n
1. An anti-itch gel, for treating itching of the vulvar tissues, comprising: 20-60% by weight water,a water-soluble salt of pramoxine,a pH modifier,from 5 to 60% by weight of a protectant, anda water-in-oil emulsifier comprising one or more silicones, where the gel has a turbidity of less than 100 nephelometric turbidity units and the gel has a pH from 4 to 7, andthe gel comprises colloidal particles having average particle diameters of from 1 to 50 microns. 2. The gel of claim 1 having a turbidity of less than 40 nephelometric turbidity units. 3. The gel of claim 1 having a turbidity of from 25 to 35 nephelometric turbidity units. 4. The gel of claim 1, where the gel comprises colloidal particles having average particle diameters of from 2 to 8 microns. 5. The gel of claim 1 having a turning force of at most 70 Eta[Pas] between 0 and 5 turns per second when measured on a rheometer. 6. The gel of claim 1 having a pH from 5 to 5.3. 7. The gel of claim 1, where water comprises from 37 to 42% of the gel by weight. 8. The gel of claim 1, where the water-in-oil emulsifier comprises at least one silicone. 9. The gel of claim 8, where the water-in-oil emulsifier comprises from 5 to 20% of the gel by weight. 10. The gel of claim 8, where the water-in-oil emulsifier comprises from 10 to 12% of the gel by weight. 11. The gel of claim 1, where the water-in-oil emulsifier comprises a dimethicone copolyol based emulsifier. 12. The gel of claim 11, where the dimethicone copolyol based emulsifier comprises a cyclopentasiloxane and a non-volatile dimethicone. 13. The gel of claim 1 comprising less than 10% by weight of a substantially water-soluble surfactant. 14. The gel of claim 1, further comprising from 0.01 to 1% by weight of a preservative. 15. The gel of claim 1, further comprising from 2 to 20% by weight of a silicone- based emollient. 16. The gel of claim 15, where the silicone-based emollient comprises a cyclomethicone. 17. The gel of claim 1, where the water-soluble anesthetic comprises from 0.5 to 2% by weight of a salt of pramoxine. 18. The gel of claim 1, where the water-soluble anesthetic comprises from 0.9 to 1.1% by weight of a salt of pramoxine. 19. The gel of claim 1, where the pH modifier comprises from 0.005 to 0.08% by weight of the gel and comprises a base. 20. The gel of claim 1, where the protectant comprises glycerin. 21. The gel of claim 20, where the protectant comprises from 20 to 45% by weight of the gel. 22. The gel of claim 1, where the protectant comprises dimethicone and comprises from 5 to 30% by weight of the gel. 23. The gel of claim 1, further comprising at least one odor modifier. 24. A method for treating vulvar discomfort, comprising: contacting vulvar tissue with the anti-itch gel of claim 1. 25. A method of forming the anti-itch gel of claim 1, comprising: combining a water phase with an oil phase after matching the refractive indices of the water and oil phases to within 0.0004 to 0.0017 to provide the gel a turbidity of less than 100 nephelometric turbidity units; wherethe water phase comprises the water, the water-soluble anesthetic, and the protectant; andthe oil phase comprises the water-in-oil emulsifier. 26. The method of claim 25, where the gel comprises colloidal particles having average particle diameters of from 2 to 8 microns. 27. The method of claim 25, where the gel has a pH from 5 to 5.3. 28. The method of claim 25, where the water-in-oil emulsifier comprises from 5 to 20% of the gel by weight and comprises a dimethicone copolyol based emulsifier. 29. The method of claim 28, where the dimethicone copolyol based emulsifier comprises a cyclopentasiloxane and a non-volatile dimethicone. 30. The method of claim 25, where the oil phase further comprises a silicone-based emollient comprising a cyclomethicone. 31. The method of claim 25, where the protectant comprises glycerin. 32. The gel of claim 1, comprising: 0.5 to 2% by weight of the water-soluble salt of pramoxine,the pH modifier,20 to 45% by weight of the protectant,5 to 20% by weight of the water-in-oil emulsifier,where the gel has a turbidity of less than 40 nephelometric turbidity units, and a pH from 5 to 5.3.
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