초록

Implantable medical devices adapted to erodibly release delivery media for local and regional treatment are disclosed.

대표청구항 ▼

1. A method of forming a coating material comprising: forming a first non-aqueous solution from a first polymer dissolved in a first solvent;forming a second non-aqueous solution from a second polymer dissolved in a second solvent, wherein the second solvent is immiscible with the first solvent; and

1. A method of forming a coating material comprising: forming a first non-aqueous solution from a first polymer dissolved in a first solvent;forming a second non-aqueous solution from a second polymer dissolved in a second solvent, wherein the second solvent is immiscible with the first solvent; andforming a mixture from the first non-aqueous solution and the second non-aqueous solution;wherein the mixture comprises polylactic acid (PLA), poly-ester-amide (PEA), cyclohexane, and methanol. 2. The method of claim 1 further comprising adding an active agent into the mixture. 3. A method of forming a coating on a medical device comprising: forming a first non-aqueous solution from a first polymer dissolved in a first solvent;forming a second non-aqueous solution from a second polymer dissolved in a second solvent, wherein the second solvent is immiscible with the first solvent;forming a mixture from the first non-aqueous solution and the second non-aqueous solution;applying the mixture to a surface of a medical device; andremoving the first and second solvents from the mixture to form a medical device coating;wherein the mixture comprises PLA, cyclohexane, PEA, and methanol. 4. The method of claim 3 wherein applying the mixture to the surface of the medical device comprises spraying the mixture onto the surface of the medical device. 5. The method of claim 3 wherein applying the mixture to the surface of the medical device comprises immersing the surface of the medical device in the mixture. 6. The method of claim 3 wherein the medical device coating comprises a particles comprising the first polymer dispersed in a matrix comprising the second polymer. 7. The method of claim 3 wherein the surface of the medical device is disposed within a cavity formed in the medical device. 8. The method of claim 3 wherein the medical device is a stent, a balloon, or a guidewire. 9. The method of claim 8 wherein the medical device is adapted to erode when implanted within a patient's body. 10. A method of forming a coating on a medical device comprising: forming a first non-aqueous solution from PLA dissolved in cyclohexane;forming a second non-aqueous solution from PEA dissolved in methanol;forming a mixture from the first non-aqueous solution and the second non-aqueous solution;applying the mixture to a surface of a medical device; andremoving the cyclohexane and methanol from the mixture to form a medical device coating. 11. The method of claim 10 wherein the medical device coating comprises particles comprising PLA dispersed in a matrix comprising PEA. 12. The method of claim 10 wherein the medical device coating comprises particles comprising PEA dispersed in a matrix comprising PLA.