IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0932078
(2007-10-31)
|
등록번호 |
US-8257433
(2012-09-04)
|
발명자
/ 주소 |
- Bates, Brian L.
- Ragheb, Anthony O.
- Fearnot, Neal E.
- Kozma, Thomas G.
- Voorhees, III, William D.
|
출원인 / 주소 |
- Cook Medical Technologies LLC
|
대리인 / 주소 |
Woodard, Emhardt, Moriarty, McNett & Henry LLP
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
148 |
초록
▼
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the
A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
대표청구항
▼
1. A coated implantable medical device, comprising: a vascular stent including a metal base material providing a lumen-facing surface of the stent and a vessel-facing surface of the stent and a thickness between the lumen-facing surface and the vessel-facing surface, wherein at least one well which
1. A coated implantable medical device, comprising: a vascular stent including a metal base material providing a lumen-facing surface of the stent and a vessel-facing surface of the stent and a thickness between the lumen-facing surface and the vessel-facing surface, wherein at least one well which is a groove or slot extending only partially through said thickness is formed in the metal base material of the stent, the at least one groove or slot containing an immunosuppressive agent applied therein. 2. The stent of claim 1, further comprising at least one porous layer posited over the at least one well and the immunosuppressive agent applied therein. 3. The stent of claim 2, wherein the at least one porous layer is composed of a polymer. 4. The stent of claim 2, wherein the at least one porous layer provides for a controlled release of the immunosuppressive agent through the at least one porous layer. 5. An implantable medical device, comprising: a vascular stent including a metal base material providing a lumen-facing surface of the stent and a vessel-facing surface of the stent and a thickness between the lumen-facing surface and the vessel-facing surface, wherein a plurality of wells which are grooves or slots extending only partially through said thickness are formed in the metal base material of the stent; andan immunosuppressive agent contained within the wells. 6. The implantable medical device of claim 5, wherein the vascular stent is a coronary stent. 7. The implantable medical device of claim 5, wherein the metal base material includes at least one of stainless steel, tantalum, titanium, nitinol, gold, platinum, inconel, iridium, silver, or tungsten. 8. The implantable medical device of claim 5, wherein the wells have downwardly extending sidewalls.
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