초록 ▼

The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening,

The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage.

대표청구항 ▼

1. A system for percutaneous transluminal closure of a cardiac opening, comprising: a catheter comprising a lumen, a proximal end, and a distal end;a frame comprising a proximal end and a distal end, the frame enclosed within the lumen of the catheter and moveable beyond the distal end of the cathet

1. A system for percutaneous transluminal closure of a cardiac opening, comprising: a catheter comprising a lumen, a proximal end, and a distal end;a frame comprising a proximal end and a distal end, the frame enclosed within the lumen of the catheter and moveable beyond the distal end of the catheter, wherein the frame comprises a plurality of arms at the frame's distal end, the plurality of arms being expandable from a closed position when maintained within the catheter to an open position when advanced beyond the distal end of the catheter, wherein each of the plurality of arms comprises a resilient coil at which the arm bends in the closed position; anda patch comprising a plurality of hollow channels, said plurality of hollow channels are enclosed within the patch having a common first end and second ends away from the common first end, and is contiguous with the lumen of the catheter, wherein the plurality of arms of the frame are maintained within the plurality of hollow channels of the patch, and wherein the plurality of arms are retractable from the plurality of hollow channels to deploy the patch. 2. The system of claim 1, wherein the patch is coated with an adhesive. 3. The system of claim 2, wherein the adhesive is a light curable adhesive, and the system further comprises a light source that projects light through the hollow channels of the patch to cure the adhesive. 4. The system of claim 1, wherein the frame comprises a shape memory alloy. 5. The system of claim 4, wherein the shape memory alloy comprises nitinol. 6. The system of claim 1, wherein the patch comprises a bioresorbable material. 7. The system of claim 1, wherein the system is configured to inject an adhesive through the hollow channels of the patch, and the patch comprises at least one hole passing from the hollow channels to a surface of the patch through which the adhesive can pass to the surface of the patch. 8. The system of claim 7, wherein the adhesive is a light curable adhesive, and the system further comprises a light source that projects light through the hollow channels of the patch to cure the adhesive.