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Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable ma

Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

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1. A bioabsorbable macromer composition of the formula selected from the group consisting of R1-[A]v-R2—R3  (IV)andR3—R2-[A]vR1-[A]v-R2—R3  (V)wherein R1 comprises a lipid segment selected from the group consisting of phosphoryl choline, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl

1. A bioabsorbable macromer composition of the formula selected from the group consisting of R1-[A]v-R2—R3  (IV)andR3—R2-[A]vR1-[A]v-R2—R3  (V)wherein R1 comprises a lipid segment selected from the group consisting of phosphoryl choline, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidyl serine, phosphatidic acid, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl glycerol, lysophosphatidyl serine, lysophosphatidic acid, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, sphingosine, aminosphingosine, and combinations thereof, R2 comprises a polymer selected from the group consisting of polysaccharides and polyols, R3 comprises a functional component selected from the group consisting of isocyanates, succinimides, aldehydes, and combinations thereof, A is a bioabsorbable group, and v is a number from about 1 to about 20. 2. A bioabsorbable macromer composition comprising: a polymeric component of the formula R3—R2-[A]v-R1-[A]v-R2—R3  (V)wherein R1 comprises a lipid segment selected from the group consisting of phosphoryl choline, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, phosphatidyl glycerol, phosphatidyl serine, phosphatidic acid, lysophosphatidyl choline, lysophosphatidyl ethanolamine, lysophosphatidyl glycerol, lysophosphatidyl serine, lysophosphatidic acid, PEG-phosphatidylethanolamine, PVP-phosphatidylethanolamine, sphingosine, aminosphingosine, and combinations thereof, R2 comprises a polymer selected from the group consisting of polysaccharides and polyols, R3 comprises a functional component selected from the group consisting of isocyanates, succinimides, aldehydes, and combinations thereof, A is a bioabsorbable group, and v is a number from about 1 to about 20; anda second component possessing at least one group reactive with the functional component on the polymeric compound. 3. A bioabsorbable macromer composition as in claim 2, wherein R2 comprises a polyol selected from the group consisting of polyethylene oxide, polyethylene glycol, polypropylene glycol, polyethylene oxide-polypropylene oxide copolymers, polyethylene glycol-adipate, polyethylene glycol-polypropylene glycol copolymers, and combinations thereof. 4. A bioabsorbable macromer composition as in claim 2, wherein R2 comprises polyethylene glycol. 5. A bioabsorbable macromer composition as in claim 2, wherein R2 comprises a polysaccharide selected from the group consisting of sorbitol, mannitol, sucrose, dextran, and cyclodextrin. 6. A bioabsorbable macromer composition as in claim 2, wherein the bioabsorbable group is selected from the group consisting of lactic acid, glycolic acid, glycolide, lactide, c-caprolactone, trimethylene carbonate, 1,4-dioxane-2-one, 1,3-dioxane-2-one, succinnic acid, adipic acid, sebacic acid, malonic acid, glutaric acid, azelaic acid, ethyl dichlorophosphate, sebacic acid anhydride, azelaic acid anhydride, and combinations thereof. 7. A bioabsorbable macromer composition as in claim 2, wherein the bioabsorbable group is selected from the group consisting of lactide, glycolide, e-caprolactone, p-dioxanone, trimethylene carbonate, and combinations thereof. 8. A bioabsorbable macromer composition as in claim 2, wherein v is a number from about 2 to about 6. 9. A bioabsorbable macromer composition as in claim 2, wherein the isocyanate group is selected from the group consisting of 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, 2,2′-diphenylmethane diisocyanate, 2,4′-diphenylmethane diisocyanate, 4,4′-diphenylmethane diisocyanate, diphenyldimethylmethane diisocyanate, dibenzyl diisocyanate, naphthylene diisocyanate, phenylene diisocyanate, xylylene diisocyanate, 4,4′-oxybis(phenyl isocyanate), tetramethylxylylene diisocyanate, tetramethylene diisocyanate, hexamethylene diisocyanate, lysine diisocyanate, 2-methylpentane-1,5-diisocyanate, 3-methylpentane-1,5-diisocyanate, 2,2,4-trimethylhexamethylene diisocyanate, isophorone diisocyanate, cyclohexane diisocyanate, hydrogenated xylylene diisocyanate, hydrogenated diphenylmethane diisocyanate, hydrogenated trimethylxylylene diisocyanate, 2,4,6-trimethyl 1,3-phenylene diisocyanate, and combinations thereof. 10. A bioabsorbable macromer composition as in claim 2, wherein the second component possesses at least one isocyanate-reactive group selected from the group consisting of at least one hydroxy group, at least one amine group, at least one sulfhydryl group, and combinations thereof. 11. A bioabsorbable macromer composition as in claim 10, wherein the second component possessing at least one hydroxy group is selected from the group consisting of water, polyether-based polyols, polycaprolactone-based polyols, and polyhydric alcohols, disaccharides, and combinations thereof. 12. A bioabsorbable macromer composition as in claim 10, wherein the second component possessing at least one amine group is selected from the group consisting of bis(3-aminopropyl)amine, spermine, polyetheramines, trilysine, polylysine, polyarginine, albumin, ethylenediamine, N-ethylethylenediamine, N,N′-diethylethylenediamine, butane-1,4-diamine, pentane-1,5-diamine, hexane-1,6-diamine, phenylene diamine, ethanolamine, N-ethylethanolamine, triethylenediamine, N-methylmorpholine, pentamethyl diethylenetriamine, dimethylcyclohexylamine, tetramethylethylenediamine, 1-methyl-4-dimethylaminoethyl-piperazine, 3-methoxy-N-dimethyl-propylamine, N-ethylmorpholine, diethylethanolamine, N-cocomorpholine, N,N-dimethyl-N′N-dimethylisopropyl-propylene diamine, N,N-diethyl-3-diethyl aminopropylamine, dimethyl-benzyl amine, and combinations thereof. 13. A bioabsorbable macromer composition as in claim 10, wherein the second component possessing at least one amine group comprises a diamine of the formula NH2—R4—NH2  (VI)wherein R4 comprises a polymer selected from the group consisting of polysaccharides and polyols. 14. A bioabsorbable macromer composition as in claim 10, wherein the second component possessing at least one sulfhydryl group is selected from the group consisting of thiolated gelatin, thiolated collagen, PEG-thiols, pentaerythritol tetrakis(2-mercaptoacetate), pentaerythritol tetrakis(3-mercaptopropionate), trimethylolpropane tris(2-mercaptoacetate), trimethylolpropane tris(2-mercaptopropionate), and combinations thereof. 15. A method for closing a wound comprising: applying the bioabsorbable macromer composition of claim 2 to said wound; andallowing the bioabsorbable macromer composition to set thereby closing said wound. 16. The method of claim 15 wherein the wound is a surgical incision. 17. A method for filling a void in animal tissue comprising: applying the bioabsorbable macromer composition of claim 2 to said void; andallowing the bioabsorbable macromer composition to set thereby filling said void. 18. A method for adhering a medical device to a surface of animal tissue comprising the steps of: applying the bioabsorbable macromer composition of claim 2 to said device, said surface or both;bringing the device, bioabsorbable macromer composition and surface into contact with each other; andallowing the bioabsorbable macromer composition to set thereby adhering the device and surface to each other. 19. The method of claim 18, wherein said medical device is an implant.