IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0137386
(2011-08-10)
|
등록번호 |
US-8268612
(2012-09-18)
|
발명자
/ 주소 |
- Owen, Donald R.
- Kravitz, David C.
- Brassil, John
- Brockbank, Kelvin G. M.
- Burroughs, Andrew
- Schein, Douglas
- Isaacs, Dickon
|
출원인 / 주소 |
- Lifeline Scientific, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
16 인용 특허 :
97 |
초록
▼
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
대표청구항
▼
1. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising: a portable housing; andan organ supporting surface configured to support an organ within said housing, wherein the portable housing is configured to be received by at least
1. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising: a portable housing; andan organ supporting surface configured to support an organ within said housing, wherein the portable housing is configured to be received by at least one of an organ perfusion device, an organ transporter and an organ diagnostic device, and includes openings configured to allow tubing to be connected to the organ by way of the openings, wherein a bottom portion of the housing is liquid tight, and wherein said organ supporting surface comprises detents, tracks or grooves that interact with a protruding region of said tubing to allow a cannula to be secured at various positions on the detents, tracks or grooves of the organ supporting surface. 2. An apparatus for holding an organ for at least one of perfusion, storage, diagnosis and transport of the organ, comprising: a portable housing including an organ supporting surface;the organ supporting surface being configured to support an organ within said housing, wherein the portable housing is configured to be received by at least one of an organ perfusion device, an organ transporter and an organ diagnostic device, and includes openings configured to allow tubing to be connected to the organ by way of the openings, wherein a bottom portion of the housing is liquid tight, and wherein an internal surface of said housing comprises detents, tracks or grooves that interact with a protruding region of said tubing to allow a cannula to be secured at various positions on the detents, tracks or grooves.
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