The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
대표청구항▼
1. A system for monitoring glucose concentration in a host, the system comprising: a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; anda receiver configured to receive the sensor data from the substantially continuous glucos
1. A system for monitoring glucose concentration in a host, the system comprising: a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host; anda receiver configured to receive the sensor data from the substantially continuous glucose sensor and receive reference data from an in vitro single point glucose monitor, the reference data indicative of a measured glucose concentration in a biological sample from the host, wherein the receiver comprises: a processor module; anda computer readable memory comprising: instructions configured to cause the processor module to determine a rate of change of the glucose concentration in the host at a time corresponding to the measured glucose concentration in the biological sample;instructions configured to determine whether the rate of change is within a range of rates of change delimited by maximum normally sustainable rates of change of glucose in humans;instructions configured to cause the processor module to calibrate the sensor data, wherein the instructions are configured to allow the processor module to calibrate the sensor data using the reference data when the rate of change is within the range, but not allow the processor module to calibrate the sensor data using the reference data when the rate of change is outside the rangeinstructions configured to cause the processor module to determine a time lag between the sensor data and the reference data based at least in part on the determined rate of change; andinstructions configured to cause the processor module to form a matched data pair by matching one or more sensor data points of the sensor data with one or more data points of the reference data using the determined time lag,wherein calibrating the sensor data is based at least in part on the matched data pair. 2. The system of claim 1, wherein the maximum normally sustainable rates of change of glucose in humans is outside a range of +/−4 mg/dL/min. 3. The system of claim 1, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions for prospective calibration. 4. The system of claim 1, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate during initialization of the continuous glucose sensor. 5. The system of claim 1, wherein the instructions configured to cause the processor module to calibrate the glucose data comprise instructions configured to calibrate after initialization of the continuous glucose sensor. 6. The system of claim 1, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate the sensor data based on reference data indicative of a single glucose concentration measured by the in vitro single point glucose monitor. 7. The system of claim 1, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate the sensor data based on reference data indicative of more than one glucose concentration measured by the in vitro single point glucose monitor. 8. The system of claim 1, wherein the computer readable memory further comprises instructions configured to cause the processor module to filter the sensor data. 9. The system of claim 8, wherein the instructions configured to filter the sensor data are further configured to cause the processor module to adaptively filter the sensor data. 10. The system of claim 9, wherein the instructions configured to adaptively filter the sensor data are configured to cause the processor module to adaptively filter the sensor data based on a detection of signal artifacts. 11. The system of claim 9, wherein the instructions configured to adaptively filter the sensor data are configured to cause the processor module to adaptively filter the sensor data based on the rate of change of the calibrated sensor data. 12. The system of claim 8, wherein the instructions configured to calculate a rate of change are configured to cause the processor module to calculate a rate of change based on the filtered sensor data. 13. The system of claim 1, wherein the in vitro glucose monitor is integrated with the receiver. 14. A system for monitoring glucose concentration in a host, the system comprising: a substantially continuous glucose sensor configured to produce sensor data indicative of a glucose concentration in a host;a communications module configured to receive the sensor data from the substantially continuous glucose sensor and receive reference data from an in vitro single point glucose monitor, the in vitro single point glucose monitor configured to receive a biological sample from the host and to measure a glucose concentration in the sample, wherein the reference data is indicative of the measured glucose concentration in the sample;a processor module; anda computer readable memory comprising instructions that, when executed by the processor module, are configured to cause the processor module to: calibrate the sensor data received from the substantially continuous glucose sensor;determine a rate of change of the calibrated sensor data;not calibrate the sensor data using the glucose concentration measured by the single point glucose monitor when the rate of change of the calibrated sensor data is outside of a range of +/−4 mg/dL/min; anddetermine a time lag between the sensor data and the glucose concentration measured by the in vitro single point glucose monitor using at least the determined rate of change,wherein calibrating the sensor data comprises compensating for the time lag. 15. The system of claim 14, wherein the range is +/−5 mg/dL/min. 16. The system of claim 14, wherein the range is +/−6 mg/dL/min. 17. The system of claim 14, wherein the reference data includes a time stamp of the glucose concentration measured by the in vitro single point glucose monitor. 18. The system of claim 14, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions for prospective calibration. 19. The system of claim 14, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate during initialization of the continuous glucose sensor. 20. The system of claim 14, wherein the instructions configured to cause the processor module to calibrate the glucose data comprise instructions configured to calibrate after initialization of the continuous glucose sensor. 21. The system of claim 14, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate the sensor data based on a single glucose concentration measured by the in vitro single point glucose monitor. 22. The system of claim 14, wherein the instructions configured to cause the processor module to calibrate the sensor data comprise instructions configured to calibrate the sensor data based on more than one glucose concentration measured by the in vitro single point glucose monitor. 23. The system of claim 14, wherein the instructions are further configured to cause the processor module to filter the sensor data. 24. The system of claim 23, wherein the instructions configured to filter the sensor data are further configured to adaptively filter the sensor data. 25. The system of claim 24, wherein the instructions configured to adaptively filter the sensor data are configured to adaptively filter the sensor data based on a detection of signal artifacts. 26. The system of claim 24, wherein the instructions configured to adaptively filter the sensor data are configured to adaptively filter the sensor data based on the rate of change of the calibrated sensor data. 27. The system of claim 23, wherein the instructions configured to calculate a rate of change are configured to calculate a rate of change based on the filtered sensor data. 28. The system of claim 14, wherein the communication module, the processor module and the instructions are incorporated into a receiver device. 29. The system of claim 28, wherein the in vitro single point glucose monitor is integral with the receiver device.
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Schaffar Bernhard (Graz ATX) Kontschieder Heinz (Graz ATX) Dolezal Andreas (Graz ATX) Ritter Christoph (Graz ATX), Planar sensor for determining a chemical parameter of a sample.
Clark ; Jr. Leland (Cincinnati OH), Polarographic method for measuring both analyte and oxygen with the same detecting electrode of an electroenzymatic sens.
Betts Ronald E. (La Jolla CA) Savage Douglas R. (Del Mar CA) Leader Matthew J. (Laguna Niguel CA), Portable analyte measuring system for multiple fluid samples.
Neuenfeldt Steven (Vernon Hills IL) Brauker James (Lake Ville IL) Clarke Robert (Libertyville IL), Ported tissue implant systems and methods of using same.
Swette Larry L. ; Griffith Arthur E. ; LaConti Anthony B., Potential and diffusion controlled solid electrolyte sensor for continuous measurement of very low levels of transdermal.
Fidler John C. (DeKalb) Bobis James P. (Downers Grove) Penrose William R. (Naperville) Stetter Joseph R. (Naperville IL), Potentiostatic apparatus and methods.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S., Process for producing an electrochemical biosensor.
Carr Daniel J. (Harleysville PA) Scally Charles R. (Warminister PA) Carney Michael D. (Havertown PA) Kern Scott L. (Perkasie PA) Satko Thomas A. (Ivyland PA) Zecca James W. (Telford PA), Programmable electronic display for a chart recorder.
Phillips Roger (Palo Alto CA) McGarraugh Geoffery (Scotts Valley CA) Jurik Franklin A. (San Mateo CA) Underwood Raymond D. (Red Bluff CA), Reagent test strip and apparatus for determination of blood glucose.
Shin, John J.; Holtzclaw, Kris R.; Dangui, Nandita D.; Kanderian, Jr., Sami; Mastrototaro, John J.; Hong, Peter I., Real time self-adjusting calibration algorithm.
Schulman Joseph H. (Santa Clarita CA) Mann Alfred E. (Beverly Hills CA), Replaceable catheter system for physiological sensors, tissue stimulating electrodes and/or implantable fluid delivery s.
Reghabi,Bahar; Shah,Rajiv; Jin,Eunjoo; Gottlieb,Rebecca; Miller,Michael E.; Van Antwerp,Nannette M.; Enegren,Bradley J.; Van Antwerp,William P.; Mastrototaro,John J., Reusable analyte sensor site and method of using the same.
Yafuso Masao (Lake Forest CA) Pratt Ronnie L. (Hammond WI) Bretscher Kathryn R. (Shoreview MN) Wood Kenneth B. (St. Paul MN) Dektar John L. (Laguna Hills CA) Bentsen James G. (North St. Paul MN), Sensing elements and methods for uniformly making individual sensing elements.
Karinka, Shridhara Alva; Moser, Isabella; Jobst, Gerhard; Tietjen, Uwe; Petrou, Panagiota S.; Herberth, Uwe; Urban, Gerald, Sensor having electrode for determining the rate of flow of a fluid.
McCaffrey Robert ; Tkacik Katarina ; Holman Brian ; Flaherty James ; Brown Josef ; Edelman Peter, Sensors for measuring analyte concentrations and methods of making same.
Brauker, James H.; Carr-Brendel, Victoria; Goode, Paul V.; Kamath, Apurv U.; Thrower, James P.; Xavier, Ben, Signal processing for continuous analyte sensor.
Berner Bret ; Dunn Timothy C. ; Farinas Kathleen C. ; Garrison Michael D. ; Kurnik Ronald T. ; Lesho Matthew J. ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Signal processing for measurement of physiological analysis.
Benjamin J. Feldman ; Adam Heller ; Ephraim Heller ; Fei Mao ; Joseph A. Vivolo ; Jeffery V. Funderburk ; Fredric C. Colman ; Rajesh Krishnan, Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator.
Cordero Rafael M. ; Devlin Philip H. ; Chamoun Nassib G. ; Shambroom John R. ; Merrick Edwin B. ; Melo Joao, Smart electrophysiological sensor system with automatic authentication and validation and an interface for a smart electrophysiological sensor system.
Sheridan, Margaret M.; Bries, James L.; Malmer, Jeffrey D.; Sherman, Audrey A.; Kinning, David J., Stretch releasing pressure sensitive adhesive tape and articles.
Hill Hugh Allen Oliver (Oxford GB3) Higgins Irving John (Bedford GB3) McCann James Michael (Oxford GB3) Davis Graham (Plainsborough NJ), Strip electrode with screen printing.
Keith,Steven; Parker,Robert S.; Harvey,Noel G.; Pettis,Ronald J.; DeNuzzio,John D.; Vonk,Glenn, System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or .
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Mann, Alfred E.; Purvis, Richard E.; Mastrototaro, John J.; Causey, James D.; Henke, James; Hong, Peter; Livingston, John H.; Hague, Clifford W.; Hite, Brad T., Telemetered characteristic monitor system and method of using the same.
Bayerl Thomas,DEX ; Decher Gero,DEX ; Braunschweig Thomas,DEX, Template induced patterning of surfaces and their reversible stabilization using phase transitions of the patterned material.
Brauker James H. (Harvard IL) Hill Ronald S. (Grayslake IL) Martinson Laura A. (Lake Villa IL) Boggs Daniel R. (Libertyville IL) Johnson Robert C. (Bartlett IL), Tissue implant systems and methods for sustaining viable high cell densities within a host.
Brauker James H. (Harvard IL) Hill Ronald S. (Grayslake IL) Martinson Laura A. (Lake Villa IL) Boggs Daniel R. (Libertyville IL) Johnson Robert C. (Bartlett IL), Tissue inplant systems and methods for sustaining viable high cell densities within a host.
Cheney ; II Paul S. (Beverly Hills CA) Mastrototaro John J. (Los Angeles CA) Schnabel Nannette M. (Valencia CA) Lord Peter C. (Valencia CA) Van Antwerp William P. (Los Angeles CA) Clark Raymond D. (V, Transcutaneous sensor insertion set.
Lord Peter C. (Santa Clarita CA) Van Antwerp William P. (Brentwood CA) Mastrototaro John J. (Los Angeles CA) Cheney ; II Paul S. (Beverly Hills CA) Schnabel Nannette M. (Valencia CA), Transcutaneous sensor insertion set.
Band David M. (88 Ditton Road ; Surbiton Surrey GBX) Penman David G. (No. 1 Brief Street ; Myatts Field London UT GBX) Kratochvil Jiri (3551 S. Canyon Way Salt Lake City UT), pH electrode.
Shah, Rajiv; Mucic, Robert C.; de Barros, Genival D.; Callirgos, Carlos A.; Sirigiri, Manjunath; Brinson, Joseph Paul, Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods.
Szyman, Catherine M.; Miller, Michael E.; Shah, Rajiv, Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods.
Szyman, Catherine M.; Miller, Michael E.; Shah, Rajiv, Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods.
Wang, Jenn-Hann Larry; Miller, Michael E.; Gautham, Raghavendhar; Li, Yiwen; Shah, Rajiv, Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods.
Wang, Jenn-Hann Larry; Miller, Michael E.; Gautham, Raghavendhar; Li, Yiwen; Shah, Rajiv, Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods.
Askarinya, Mohsen; Brown, Richard L.; Chong, Colin A.; Kinzie, Patrick W.; Schulhauser, Randal; Cherry, Jeff M.; Stevenson, Tyler S., Electronic injector.
Yap, Darren Y. K.; Link, Carl A.; Chow, Vincent Ming Hai; Dannemann, William Jackson; Reitmajer, Jennifer Marie, Insulin pump data acquisition device and system.
Kristensen, Jesper Svenning; Dang, Tri T.; Knarreborg, Katharine; Bansal, Anubhuti, Methods and materials for modulating start-up time and air removal in dry sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Varsavsky, Andrea; Li, Xiaolong; Liu, Mike C.; Zhong, Yuxiang; Yang, Ning, Methods and systems for improving the reliability of orthogonally redundant sensors.
Lebel, Ronald J.; Starkweather, Timothy J.; Weiss, Philip T., Microprocessor controlled ambulatory medical apparatus with hand held communication device.
Askarinya, Mohsen; Brown, Richard L.; Chong, Colin A.; Kinzie, Patrick W.; Schulhauser, Randal; Cherry, Jeff M.; Stevenson, Tyler S., On-body injector and method of use.
Markle, David R.; Wessling, Ritchie A.; Kolehmainen, Donald J., Optical systems and methods for ratiometric measurement of blood glucose concentration.
Adamczyk, Robert G.; Freger, Mark; Lewinski, David P.; Rankers, Ulrich H.; Val Verde, Lisa M.; Vargas, Steven J.; Wang, Yongbo, Personal medical device and method of use with restricted mode challenge.
Parikh, Neha J.; Roy, Anirban; Keenan, Desmond Barry; Mastrototaro, John J.; Grosman, Benyamin, Regulating entry into a closed-loop operating mode of an insulin infusion system.
Starkweather, Timothy J.; Lebel, Ronald J.; Shah, Rajiv; Miller, Michael E., System and method for providing closed loop infusion formulation delivery.
Meng, Fan; Cohen, Gary A.; Dempster, Eileen H.; Patterson, George W.; Talbot, Cary D.; Verghese, Mark Sebastian; Gharib, Maral, Variable data usage personal medical system and method.
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