초록 ▼

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers;

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.

대표청구항 ▼

1. A hemostatic textile, comprising: a material comprising glass fibers and raw or regenerated bamboo fibers co-woven or knitted together, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 0.1% to about 99.9% by weight glass fibers and from

1. A hemostatic textile, comprising: a material comprising glass fibers and raw or regenerated bamboo fibers co-woven or knitted together, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 0.1% to about 99.9% by weight glass fibers and from about 99.9% to about 0.1% by weight raw or regenerated bamboo fibers, based on the total weight of said textile; andthrombin or a fraction comprising thrombin;said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. 2. The hemostatic textile of claim 1, wherein said fraction comprising thrombin further comprises one or more coagulation factors selected from the group consisting of factor XII, factor XIIa, factor XI, factor XIa, factor XIII, factor XIIIa, factor IX, factor IXa, factor VIII, factor VIIIa, factor vWF, factor V, factor Va, factor X, factor Xa, and combinations thereof. 3. The hemostatic textile of claim 1, wherein said fraction further comprises a vasoactive agent. 4. The hemostatic textile of claim 3, wherein said vasoactive agent is selected from the group consisting of endothelins, thromoboxanes, NO scavengers, and combinations thereof. 5. The hemostatic textile of claim 1, further comprising a preservative selected from the group consisting of glycerol, propanediol, polyoxyethylene glycol (PEG), trehalose, and combinations thereof. 6. The hemostatic textile of claim 1, wherein said fraction comprising thrombin is a partially purified plasma fraction containing thrombin IIa. 7. The hemostatic textile of claim 1, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 30% to about 80% by weight glass fibers and from about 70% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 8. The hemostatic textile of claim 1, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 50% to about 80% by weight glass fibers and from about 50% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 9. The hemostatic textile of claim 1, wherein said thrombin or a fraction comprising thrombin comprises from about 0.01% to about 10% by weight, based on the total weight of said textile. 10. The hemostatic textile of claim 1, wherein said thrombin or a fraction comprising thrombin comprises from about 0.05% to about 7% by weight, based on the total weight of said textile. 11. The hemostatic textile of claim 1, wherein said thrombin or a fraction comprising thrombin comprises from about 0.1% to about 5% by weight, based on the total weight of said textile. 12. The hemostatic textile of claim 1, further comprising one or more additional agents selected from the group consisting of skin conditioners, anti-inflammatory agents, analgesics, antimicrobial or antifungal agents, vasoconstrictors, growth factors, anti-scar agents, cauterizing agents, dehydrating agents, prothrombotic agents, and combinations thereof. 13. The hemostatic textile of claim 1, wherein said textile material is in a woven form. 14. The hemostatic textile of claim 1, wherein said hemostatic textile is an article of clothing or a liner for an article of clothing. 15. A hemostatic textile, comprising: a material comprising a combination of about 65% by weight glass fibers and about 35% by weight raw or regenerated bamboo fibers, based on the total weight of said textile wherein the glass fibers and the raw or regenerated bamboo fibers are co-woven or knitted together; andfrom about 0.1% to about 5% by weight of thrombin or a fraction comprising thrombin based on the total weight of said textile;said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. 16. A hemostatic textile, comprising: a material comprising glass fibers and raw or regenerated bamboo fibers co-woven or knitted together, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 0.1% to about 99.9% by weight glass fibers and from about 99.9% to about 0.1% by weight raw or regenerated bamboo fibers, based on the total weight of said textile; andone or more hemostatic agents selected from the group consisting of rehydrated lyophilized (RL) platelets, RL blood cells, fibrin, and fibrinogen;said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. 17. The hemostatic textile of claim 16, further comprising one or more coagulation factors selected from the group consisting of factor XII, factor XIIa, factor XI, factor XIa, factor XIII, factor XIIIa, factor IX, factor IXa, factor VIII, factor VIIIa, factor vWF, factor V, factor Va, factor X, factor Xa, and combinations thereof. 18. The hemostatic textile of claim 16, further comprising a vasoactive agent. 19. The hemostatic textile of claim 18, wherein said vasoactive agent is selected from the group consisting of endothelins, thromoboxanes, NO scavengers, and combinations thereof. 20. The hemostatic textile of claim 16, further comprising a preservative selected from the group consisting of glycerol, propanediol, polyoxyethylene glycol (PEG), trehalose, and combinations thereof. 21. The hemostatic textile of claim 16, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 30% to about 80% by weight glass fibers and from about 70% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 22. The hemostatic textile of claim 16, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 50% to about 80% by weight glass fibers and from about 50% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 23. The hemostatic textile of claim 16, wherein said RL platelets or said RL blood cells comprise from about 0.1% to about 20% by weight, based on the total weight of said textile. 24. The hemostatic textile of claim 16, wherein said fibrin or fibrinogen comprises from about 0.1% to about 5% by weight, based on the total weight of said textile. 25. The hemostatic textile of claim 16, further comprising one or more additional agents selected from the group consisting of skin conditioners, anti-inflammatory agents, analgesics, antimicrobial or antifungal agents, vasoconstrictors, growth factors, anti-scar agents, cauterizing agents, dehydrating agents, prothrombotic agents, and combinations thereof. 26. The hemostatic textile of claim 16, wherein said textile material is in a woven form. 27. The hemostatic textile of claim 16, wherein said hemostatic textile is an article of clothing or a liner for an article of clothing. 28. A hemostatic textile, comprising: a material comprising a combination of about 65% by weight glass fibers and about 35% by weight raw or regenerated bamboo fibers, based on the total weight of said textile, wherein the glass fibers and the raw or regenerated bamboo fibers are co-woven or knitted together; andone or more hemostatic agents selected from the group consisting of rehydrated lyophilized (RL) platelets, RL blood cells, fibrin, and fibrinogen, wherein said RL platelets and said RL blood cells comprise from about 0.1% to about 20% by weight and said fibrin and said fibrinogen comprise from about 0.1% to about 5% by weight, based on the total weight of said textile;said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. 29. A hemostatic textile, comprising: a material comprising glass fibers and raw or regenerated bamboo fibers co-woven or knitted together, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 0.1% to about 99.9% by weight glass fibers and from about 99.9% to about 0.1% by weight raw or regenerated bamboo fibers, based on the total weight of said textile; andthrombin or a fraction containing thrombin; andone or more hemostatic agents selected from the group consisting of rehydrated lyophilized (RL) platelets, RL blood cells, fibrin, and fibrinogen;said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. 30. The hemostatic textile of claim 29, wherein said fraction further comprises one or more coagulation factors selected from the group consisting of factor XII, factor XIIa, factor XI, factor XIa, factor XIII, factor XIIIa, factor IX, factor IXa, factor VIII, factor VIIIa, factor vWF, factor V, factor Va, factor X, factor Xa, and combinations thereof. 31. The hemostatic textile of claim 29, wherein said fraction further comprises a vasoactive agent. 32. The hemostatic textile of claim 31, wherein said vasoactive agent is selected from the group consisting of endothelins, thromoboxanes, NO scavengers, and combinations thereof. 33. The hemostatic textile of claim 29, further comprising a preservative selected from the group consisting of glycerol, propanediol, polyoxyethylene glycol (PEG), trehalose, and combinations thereof. 34. The hemostatic textile of claim 29, wherein said fraction comprising thrombin is a partially purified plasma fraction containing thrombin IIa. 35. The hemostatic textile of claim 29, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 30% to about 80% by weight glass fibers and from about 70% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 36. The hemostatic textile of claim 29, wherein the relative amounts of said glass fibers and said raw or regenerated bamboo fibers range from about 50% to about 80% by weight glass fibers and from about 50% to about 20% by weight raw or regenerated bamboo fibers, based on the total weight of said textile. 37. The hemostatic textile of claim 29, wherein said thrombin or a fraction comprising thrombin comprises from about 0.01% to about 10% by weight, based on the total weight of said textile. 38. The hemostatic textile of claim 29, wherein said thrombin or a fraction comprising thrombin comprises from about 0.05% to about 7% by weight, based on the total weight of said textile. 39. The hemostatic textile of claim 29, wherein said thrombin or a fraction comprising thrombin comprises from about 0.1% to about 5% by weight, based on the total weight of said textile. 40. The hemostatic textile of claim 29, wherein said RL platelets or said RL blood cells comprise from about 0.1% to about 20% by weight, based on the total weight of said textile. 41. The hemostatic textile of claim 29, wherein said fibrin or fibrinogen comprises from about 0.1% to about 5% by weight, based on the total weight of said textile. 42. The hemostatic textile of claim 29, further comprising one or more additional agents selected from the group consisting of skin conditioners, anti-inflammatory agents, analgesics, antimicrobial or antifungal agents, vasoconstrictors, growth factors, anti-scar agents, cauterizing agents, dehydrating agents, prothrombotic agents, and combinations thereof. 43. The hemostatic textile of claim 29 in a woven form. 44. The hemostatic textile of claim 29, wherein said hemostatic textile is an article of clothing or a liner for an article of clothing. 45. A hemostatic textile, comprising: a textile material comprising a combination of about 65% by weight glass fibers and about 35% by weight raw or regenerated bamboo fibers, based on the total weight of said textile wherein the glass fibers and the raw or regenerated bamboo fibers are co-woven or knitted together;from about 0.1% to about 5% by weight of thrombin or a fraction comprising thrombin based on the total weight of said textile; andone or more hemostatic agents selected from the group consisting of rehydrated lyophilized (RL) platelets, RL blood cells, fibrin, and fibrinogen, wherein said RL platelets and said RL blood cells comprise from about 0.1% to about 20% by weight and said fibrin and said fibrinogen comprise from about 0.1% to about 5% by weight, based on the total weight of said textile; said hemostatic textile capable of activating hemostatic systems in the body when applied to a wound.