초록

The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

대표청구항 ▼

1. A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising: a co-condensed silica network comprising a nitric oxide donor, wherein the nitric oxide donor is formed prior to condensation of the co-condensed silica network, wherein the co-condensed silica network is synthesiz

1. A nitric oxide-releasing particle, the nitric oxide-releasing particle comprising: a co-condensed silica network comprising a nitric oxide donor, wherein the nitric oxide donor is formed prior to condensation of the co-condensed silica network, wherein the co-condensed silica network is synthesized from the condensation of a silane mixture comprising an alkoxysilane and at least one aminoalkoxysilane having an amine substituted by a diazeniumdiolate. 2. The nitric oxide-releasing particle of claim 1, wherein the alkoxysilane comprises a tetraalkoxysilane of the formula Si(OR)4, wherein R is alkyl; and the aminoalkoxysilane has the formula R″—N(NONO−X+)—R′—Si(OR)3, wherein R is alkyl, R′ is alkylene or aralkylene, R″ is alkyl or alkylamine, and X+is a cation selected from the group consisting of Na+ and K+. 3. The nitric oxide-releasing particle of claim 2, wherein the silane mixture comprises between about 10 mol % to about 99 mol % of the tetraalkoxysilane and about 1 mol % to about 90 mol % of the aminoalkoxysilane having an amine substituted by a diazeniumdiolate. 4. The nitric oxide-releasing particle of claim 3, wherein the silane mixture further comprises about 0 mol % to about 20 mol % of a fluorinated silane; about 0 mol % to about 20 mol % of a cationic or anionic silane; and about 0 mol % to about 20 mol % of an alkylsilane. 5. The nitric oxide-releasing particle of claim 2, wherein the tetraalkoxysilane is selected from the group consisting of tetraniethyl orthosilicate and tetraethyl orthosilicate. 6. The nitric oxide-releasing particle of claim 4, wherein the fluorinated silane is selected from the group consisting of: (heptadecafluoro-1,1,2,2-tetrahydrodecyl)triethoxysilane;(3,3,3-trifluoropropyl)trimethoxysilane; and (perfluoroalkyl)ethyltriethoxysilane. 7. The nitric oxide-releasing particle of claim 4, wherein the cationic or anionic silane is selected from the group consisting of: N—N-didecyl-N-methyl-N-(3-trimethoxysilylpropyparrimoniurn chloride; octadecyldimethyl(3-trimethoxysilylpropyl)ammonium chloride; 3-trihydroxysilylpropylmethyl phosphonate, sodium salt; and carboxylethylsilanetriol, sodium salt. 8. The nitric oxide-releasing particle of claim 4, wherein the alkylsilane is selected from the group consisting of methyltrimethoxysilane, butyltrimethoxysilarie, butyltriethoxysilane, propyltrimethoxysilane, and octadecyltrimethoxysilane. 9. The nitric oxide-releasing particle of claim 1, wherein the particle has a diameter of from about 1 nm to about 1000 nm. 10. The nitric oxide-releasing particle of claim 1, wherein the particle has a diameter of from about 1 nm to about 5 nm. 11. The nitric oxide-releasing particle of claim 1, wherein the particle has a diameter of from about 2 nm to about 10 μm.