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Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence

Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.

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1. A method for removing an epithelial layer disposed over a stromal layer in a cornea, the method comprising: irradiating a region of the epithelial layer with a pulsed ablation beam of an ablative radiation such that the pulsed ablation beam ablates the epithelium;scanning the ablative radiation t

1. A method for removing an epithelial layer disposed over a stromal layer in a cornea, the method comprising: irradiating a region of the epithelial layer with a pulsed ablation beam of an ablative radiation such that the pulsed ablation beam ablates the epithelium;scanning the ablative radiation to vary a location of the ablation beam within the region in accordance with an ablation pulse sequence, wherein the ablation pulse sequence is sorted to enhance an optical feedback of the pulsed ablation beam based on a tissue fluorescence of the epithelial layer in response to the ablative radiation; anddetecting a penetration of the epithelial layer in response to the optical feedback. 2. The method of claim 1 wherein stromal tissue is ablated with an optical correction in response the penetration of the epithelial layer. 3. The method of claim 1 wherein the epithelial layer is ablated to a first depth and an additional sub-layer of epithelial tissue is ablated to a second depth in response to the optical feedback. 4. The method of claim 1 wherein a size of the laser beam is constant while the region is irradiated until the penetration of the epithelium is detected. 5. A system to ablate an eye to remove an epithelial layer of the eye, the system comprising: a laser to generate an ablation beam of an ablative radiation;a movable scan component to scan the laser ablation beam over a region of the eye to ablate the epithelial layer; anda processor comprising a tangible medium and a memory, the processor coupled to the laser and the movable scan component, the processor configured to scan the ablation beam within the region in accordance with a pulse sequence, and wherein the processor is configured to sort the pulse sequence of the ablation beam to enhance an optical feedback and wherein the pulse sequence is arranged when sorted to enhance an optical feedback signal based on a tissue fluorescence of the epithelial layer in response to the ablative radiation. 6. The system of claim 5 further comprising at least one lens to form an optical image of the fluorescence that is visible to an operator such that the operator can detect the penetration of the epithelial layer based on the optical feedback signal.