초록 ▼

A method is provided for treating a subject. The method includes administering to the subject an ingestible capsule containing one or more flexible support elements adapted to expand while in a stomach of the subject, thereby bringing a plurality of electrodes into contact with a wall of the stomach

A method is provided for treating a subject. The method includes administering to the subject an ingestible capsule containing one or more flexible support elements adapted to expand while in a stomach of the subject, thereby bringing a plurality of electrodes into contact with a wall of the stomach. The method also includes driving the electrodes to apply an electrical signal to the stomach wall at first and second times, the second time at last 24 hours after the first time. Other embodiments are also described.

대표청구항 ▼

1. Apparatus for treating a subject, comprising: an electrode device, which comprises: a plurality of electrodes;one or more flexible support elements, which are coupled to the electrodes, and are adapted to expand in a stomach of a subject, such that (a) the electrode device cannot pass from the st

1. Apparatus for treating a subject, comprising: an electrode device, which comprises: a plurality of electrodes;one or more flexible support elements, which are coupled to the electrodes, and are adapted to expand in a stomach of a subject, such that (a) the electrode device cannot pass from the stomach, and (b) at least a portion of the electrodes comes in contact with a wall of the stomach at least a portion of the time that the electrodes are in the stomach, wherein the support elements are adapted to remain in the stomach for at least 24 hours, and at least a portion of the electrode device is adapted to thereafter come apart to thereby allow passage of the electrode device from the stomach; anda control unit, adapted to drive the electrodes to apply an electrical signal to the stomach wall; andan ingestible capsule, adapted to hold the electrode device during ingestion of the capsule by the subject, and to release the electrode device in the stomach. 2. The apparatus according to claim 1, wherein the electrode device is configured to remain in the stomach for at least one week. 3. The apparatus according to claim 1, wherein the control unit is adapted to drive the electrodes to apply the electrical signal to the stomach wall responsively to eating by the subject. 4. The apparatus according to claim 1, further comprising one or more coupling elements, which couple the support elements to one another, and which are adapted to dissolve, thereby allowing the at least a portion of the electrode device to come apart. 5. The apparatus according to claim 1, wherein the support elements comprise a material adapted to dissolve, thereby allowing the at least a portion of the electrode device to come apart. 6. The apparatus according to claim 1, wherein the control unit is adapted to drive the electrodes to apply an Excitable-Tissue Control (ETC) signal to the stomach wall. 7. The apparatus according to claim 1, wherein the ingestible capsule comprises a material configured to dissolve in the stomach. 8. The apparatus according to claim 1, wherein the support elements comprise electrically conductive sections which are configured to function as the electrodes. 9. The apparatus according to claim 1, wherein the plurality of electrodes comprise one or more local sense electrodes. 10. The apparatus according to claim 1, comprising at least one physiological sensor, wherein the control unit is configured to drive the electrodes in response to a signal from the physiological sensor. 11. The apparatus according to claim 1, wherein the control unit is adapted to configure the electrical signal to increase satiety of the subject. 12. The apparatus according to claim 1, wherein the control unit is adapted to configure the signal to modulate a parameter of a contraction generated by stomach muscle of the subject. 13. The apparatus according to claim 1, wherein the electrode device is configured to be too large, while expanded, to pass through a pylorus of the subject. 14. Apparatus for treating a subject, comprising: a plurality of electrodes;one or more flexible support elements, which are coupled to the electrodes, and are adapted to expand in a stomach of a subject, such that at least a portion of the electrodes comes in contact with a wall of the stomach at least a portion of the time that the electrodes are in the stomach, the support elements adapted to remain in the stomach for at least 24 hours;a control unit, adapted to drive the electrodes to apply an electrical signal to the stomach wall and to configure the signal to modulate a blood glucose level of the subject by stimulating a non-gastric organ; andan ingestible capsule, adapted to hold the support elements, electrodes, and control unit during ingestion of the capsule by the subject, and to release the support elements, electrodes, and control unit in the stomach. 15. The apparatus according to claim 14, wherein the non-gastric organ is a pancreas of the subject, and wherein the control unit is adapted to configure the signal to modulate the blood glucose level by generating an electrical field within the stomach that directly stimulates the pancreas. 16. The apparatus according to claim 14, wherein the control unit is adapted to drive the electrodes to apply an Excitable-Tissue Control (ETC) signal to the stomach wall. 17. The apparatus according to claim 14, wherein the ingestible capsule comprises a material configured to dissolve in the stomach. 18. The apparatus according to claim 14, wherein the support elements comprise electrically conductive sections which are configured to function as electrodes. 19. The apparatus according to claim 14, wherein the plurality of electrodes comprise one or more local sense electrodes. 20. The apparatus according to claim 14, comprising at least one physiological sensor, wherein the control unit is configured to drive the electrodes in response to a signal from the physiological sensor. 21. The apparatus according to claim 14, wherein the control unit is adapted to configure the electrical signal to increase satiety of the subject. 22. The apparatus according to claim 14, wherein the control unit is adapted to drive the electrodes to apply the electrical signal to the stomach wall responsively to eating by the subject. 23. The apparatus according to claim 14, wherein the control unit is adapted to configure the signal to modulate a blood-hormone level associated with pancreatic activity. 24. The apparatus according to claim 14, wherein the control unit is adapted to configure the signal to modulate a parameter of a contraction generated by stomach muscle of the subject. 25. The apparatus according to claim 14, wherein the control unit is adapted to configure the electrical signal to reduce a blood glucose level of the subject. 26. The apparatus according to claim 14, wherein the control unit is adapted to detect eating by the subject by monitoring electrical changes in the stomach, and to drive the electrodes to apply the electrical signal to the stomach wall responsively to detecting the eating by the subject.