IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0721002
(2005-12-31)
|
등록번호 |
US-8297477
(2012-10-30)
|
우선권정보 |
DE-10 2005 001 001 (2005-01-07) |
국제출원번호 |
PCT/EP2005/014155
(2005-12-31)
|
§371/§102 date |
20080320
(20080320)
|
국제공개번호 |
WO2006/072460
(2006-07-13)
|
발명자
/ 주소 |
- Brickl, Rolf-Stefan
- Schraivogel, Jürgen
|
출원인 / 주소 |
- Boehringer Ingelheim International GmbH
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
3 |
초록
▼
A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable bet
A dosing device for dispensing small-particulate pharmaceutical preparations has at least one chamber for receiving a larger amount of the preparation and a dosing unit. A rotary valve has at least one dosing chamber for receiving a defined dose of the preparation. The dosing chamber is moveable between a filling position and a dispensing position. The rotary valve rotates about a substantially horizontal axis, and has an adjustment device for setting the volume in the dosing chamber and a twisting device. The twisting device constitutes the actuator for the adjustment device. The device is made of a plastic material carefully selected to assure that no softening agents or other volatile components will be released, which prevents drug contamination.
대표청구항
▼
1. A dosing device for dosing small-particulate pharmaceutical preparations, comprising: a base including: (i) a first feed opening through which the small-particulate pharmaceutical preparation is sourced, and (ii) a second feed opening through which a dose of the small-particulate pharmaceutical p
1. A dosing device for dosing small-particulate pharmaceutical preparations, comprising: a base including: (i) a first feed opening through which the small-particulate pharmaceutical preparation is sourced, and (ii) a second feed opening through which a dose of the small-particulate pharmaceutical preparation is dispensed, wherein the first and second feed openings are disposed radially about an axis of rotation (A) extending through the base;a rotary valve assembly being rotatable, by way of user-initiated twisting, within the base frame about the axis of rotation to at least one filling position and at least one dispensing position, the rotary valve including at least one dosing unit having at least one dosing chamber, which includes an inlet/outlet opening disposed along an axis that is transverse to the axis of rotation, wherein:(i) the inlet/outlet opening aligns with, and receives into the dosing chamber, a defined partial amount of the preparation through the first feed opening of the base when the rotary valve is rotated within the base to the at least one filling position, and(ii) the inlet/outlet opening aligns with and discharges the defined partial amount of the preparation from the dosing chamber through the second feed opening of the base when the rotary valve is rotated within the base to the at least one dispensing position; anda dosing adjustment device disposed within the rotary valve assembly and including a longitudinally extending piston having an orientation parallel to, and slidable in a direction parallel to, the axis of rotation, wherein an end face of the piston forms an axially movable wall of the at least one dosing chamber in order to simultaneously adjust: (i) a volume of the at least one dosing chamber, and (ii) a size of the inlet/outlet opening of the dosing chamber, thereby adjusting the defined partial amount of the preparation to be dispensed. 2. A dosing device according to claim 1, wherein the axis of rotation (A) is oriented perpendicularly or at an angle to a direction of height of the dosing device. 3. A dosing device according to claim 1, wherein the axis of rotation (A) is arranged parallel to a longitudinal axis aligned through the first and second feed openings, and the dosing chamber in a direction parallel to the axis of rotation (A) is characterized by a constant cross-section over its extension in such direction. 4. A dosing device according to claim 1, wherein the axis of rotation (A) is arranged inclined relative to the longitudinal axis of the first and second feed openings and the dosing chamber in a direction parallel to the axis of rotation (A) is characterized by a change of cross-section over its extension in such direction. 5. A dosing device according to claim 1, wherein: the rotary valve is mounted rotably in a circumferential direction in a guide channel in the base of the dosing device;the dosing chamber is formed by a channel or recess opening at least to one side at the external circumference of the rotary valve, thereby forming the inlet/outlet opening;the geometry of the guide channel in an installation position in an area of an extension of the dosing chamber in a longitudinal direction thereof is adapted to a cross-sectional shape of the dosing chamber in the longitudinal and circumferential directions, while forming a gap seal between wall areas defining the dosing chamber and adapted to an internal circumference of the guide channel, when turned around the axis of rotation (A). 6. A dosing device according to claim 1, wherein the first and second feed openings are arranged offset relative to one another and at an radial angle in the range of about 20° through 220° about the axis of rotation (A). 7. A dosing device according to claim 1, wherein the first and second feed openings are arranged offset relative to one another and at an radial angle in the range of about 90° through 200° about the axis of rotation (A). 8. A dosing device according to claim 1, further comprising a plurality of individual dosing chambers are provided and paired symmetrically about the axis of rotation (A), whereby the dosing chambers arranged adjacent to one another in the circumferential direction are each arranged at a constant radial angle relative to one another in the circumferential direction of the axis of rotation (A). 9. A dosing device according to claim 8, wherein the radial angle matches an angle of twist between the filling and dispensing positions. 10. A dosing device according to claim 1, wherein respective volumes of the individual dosing chambers are steplessly or stepwise adjustable. 11. A dosing device according to claim 1, wherein the dose adjustment device comprises a spindle drive. 12. A dosing device according to claim 11, wherein the spindle drive is formed by a spindle nut forming an adjustment wheel, whose rotary motion is converted to a translatory motion of the piston. 13. A dosing device according to claim 12, wherein a thread is provided on the adjustment wheel, which threadingly engages pickup elements disposed on the piston. 14. A dosing device according to claim 13, further comprising a plurality of piston elements radially disposed about the axis of rotation and each having a substantially similar configuration, wherein the pickup elements of each piston is arranged offset as a function of a pitch of the threads and a radial angle between the respective pistons. 15. A dosing device according to claim 10, further comprising a twisting device for moving the piston, wherein the twisting device comprises a drive that is combinable with the rotary valve in a torsion-proof way. 16. A dosing device according to claim 15, wherein the drive is formed by a manually operable actuator in the form of a twisting wheel. 17. A dosing device according to claim 15, wherein the rotary valve, twisting device and dosing adjustment device are arranged coaxially relatively to the axis of rotation (A). 18. A dosing device according to claim 16, wherein the twisting wheel is designed as a shell-like element encompassing the rotary valve in circumferential direction and partially in axial direction and being slidable relative thereto in axial direction, and means for realizing a form-fitting and/or frictional connection with the rotary valve. 19. A dosing device according to claim 15, wherein the actuator of the dose adjustment device is formed by the twisting device. 20. A dosing device according to claim 19, wherein: the twisting wheel of the twisting device is designed as a manually operable portioning wheel;the portioning wheel is axially slidable in longitudinal direction relative to the dose adjustment device and the rotary valve, whereby the wheel assumes at least two operating positions, a first operating position I and a second operating position II;in the first operating position I, the adjustment wheel of the dose adjustment device and the portioning wheel are connected in a torque-proof way, whereby the connection is free of a torque-proof connection between the portioning wheel and the rotary valve;in the second operating position, the adjustment wheel, the portioning wheel, and the rotary valve are connected in a torque-free way. 21. A dosing device according to claim 20, wherein the individual elements—rotary valve, portioning wheel, and adjustment wheel—are secured in the operating positions in axial direction relative to one another. 22. A dosing device according to claim 17, wherein the portioning wheel exhibits a serration on the internal circumference oriented in the longitudinal direction, and that may be meshed with complementary serration areas on the adjustment wheel and the rotary valve. 23. A dosing device according to claim 1, wherein a reservoir containing the pharmaceutical preparation may be detachably fastened on the dosing device directly or via an adapter, which reservoir fills a filling chamber with the preparation, the filling chamber communicating with the first feed opening to source the pharmaceutical preparation. 24. A dosing device according to claim 1, further comprising at least one further dosing chamber for receiving a second small-particulate pharmaceutical preparation, which further dosing chamber is connected with the second feed opening, whereby both dosing units are connected in parallel. 25. A dosing device according to claim 24, wherein both dosing chambers share the common axis of rotation (A), whereby the rotary valves are connected with one another in a torque-proof manner. 26. A dosing device according to claim 1, wherein the dosing device is made of a plastic material and preferably as designed as a molded part, whereby the plastic material is autoclavable. 27. A dosing device according to claim 1, wherein the plastic material is chosen such, that no softening agents or other volatile components are released, in order to avoid drug contamination. 28. A dosing device for dosing small-particulate pharmaceutical preparations according to claim 1, wherein the dose of the pharmaceutical preparation can be adjusted in the range of 40-800 mg or 0.4-8.0 g. 29. A dosing device according to claim 1 wherein: the dosing unit comprises an adjustment device for setting the volume of the dosing chamber, andthe adjustment device comprises a scale or a dial that indicates a relation between body weight and a preparation dose.
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