Two-part capsule to accept pharmaceutical preparations for powder inhalers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/48
A61K-031/439
출원번호
US-0970982
(2008-01-08)
등록번호
US-8298575
(2012-10-30)
우선권정보
DE-198 35 346 (1998-08-05)
발명자
/ 주소
Hochrainer, Dieter
Eckert, Josef
출원인 / 주소
Boehringer Ingelheim Pharma GmbH & Co. KG
대리인 / 주소
Morris, Michael P.
인용정보
피인용 횟수 :
1인용 특허 :
52
초록▼
The present invention relates to capsules for holding pharmaceutical preparations for powder inhalers with increased drug safety and capsules for pharmaceutical preparations for powder inhalers with improved adaptation to their use in powder inhalers. The capsules consist of water-insoluble hydropho
The present invention relates to capsules for holding pharmaceutical preparations for powder inhalers with increased drug safety and capsules for pharmaceutical preparations for powder inhalers with improved adaptation to their use in powder inhalers. The capsules consist of water-insoluble hydrophobic synthetic materials which do not significantly affect the pharmaceutical quality of the contents themselves, but which improve the usability of the filled capsules with regard to their function, their longevity, and/or the geographic location of their use, and are advantageous at various stages from manufacture up to utilization.
대표청구항▼
1. A capsule, comprising: a capsule body;a capsule cap, where the capsule body and the capsule cap are attached together telescopically so that the capsule cap is attached solidly to the capsule body in order to define and enclose a volume; anda dry, powdered pharmaceutical medicament that is suitab
1. A capsule, comprising: a capsule body;a capsule cap, where the capsule body and the capsule cap are attached together telescopically so that the capsule cap is attached solidly to the capsule body in order to define and enclose a volume; anda dry, powdered pharmaceutical medicament that is suitable for inhalation by a human patient disposed within the volume defined by the capsule body and the capsule cap,wherein the capsule body and the capsule cap are formed of solid polyethylene in which does not have any holes or pores, having a Shore hardness D in the range from 65 to 73, and having a steam permeability of less than 1.3×10−14 kg/(m2 s Pa), andwherein the capsule body and the capsule cap are both in the shape of a cylinder of round cross-section, where an elongation of the capsule is greater than one. 2. The capsule according to claim 1, wherein walls of the capsule cap and the capsule body are 0.1 mm to 0.5 mm thick. 3. The capsule according to claim 1, wherein the capsule can withstand a force acting upon its longitudinal axis and its transverse axis of up to 15 N. 4. The capsule according to claim 1, wherein the wall of the capsule has a steam permeability of 1.5×10−16 to 2×10−16 kg/(m2 s Pa). 5. The capsule according to claim 1, wherein one or more elevations or recesses are located on an inner surface of the capsule cap and one or more recesses or elevations are located on an outer surface of the capsule body, the elevations or recesses being arranged so that the elevations engage with the recesses when the capsule cap is attached to the capsule body. 6. The capsule according to claim 1, wherein a bulge runs in an annular shape around an outside surface of the capsule body perpendicular to a connecting axis of the capsule cap and the capsule body, a side of the bulge which is orientated towards an open end of the capsule body standing practically at right angles to an outer wall of the capsule body. 7. The capsule according to claim 1, wherein the joint or gap between the capsule body and the capsule cap is sealed by welding, adhesive bonding, wrapping or covering the capsule cap with a protective film. 8. The capsule according to claim 1, wherein the dry, powdered pharmaceutical medicament comprises one or more of: cromoglycic acid, reproterol, beclomethasone, terbutaline, salbutamol, salmeterol, ketotifen, orciprenaline, fluticasone, ipratropium, dexamethasone, bambuterol, tiotropium, budesonide, fenoterol, clenbuterol, prednisolone, prednisone, prednylidene, methylprednisolone, formoterol, nedocromil, insulin, ipratropium bromide, tiotropium bromide, a cortisone preparation, or an atropine derivative. 9. A capsule, comprising: a capsule bodya capsule cap, where the capsule body and the capsule cap are attached together telescopically so that the capsule cap is attached solidly to the capsule body in order to define and enclose a volume; andholding the a dry, powdered pharmaceutical medicament that is suitable for inhalation by a human patient disposed within the volume defined by the capsule body and the capsule cap,wherein the capsule body and the capsule cap are formed of solid polyethylene in which does not have any holes or pores, having a Shore hardness D in the range from 65 to 73, and having a steam permeability of less than 1.3×10−14 kg/(m2 s Pa),wherein the capsule body and the capsule cap are both in the shape of a cylinder of round cross-section, where an elongation of the capsule is greater than one, andwherein a joint between the capsule body and the capsule cap is sealed by filling with a pharmaceutically acceptable filler. 10. The capsule according to claim 9, wherein the filler is an acryl-polymer resin. 11. The capsule according to claim 9, wherein the dry, powdered pharmaceutical medicament comprises one or more of: cromoglycic acid, reproterol, beclomethasone, terbutaline, salbutamol, salmeterol, ketotifen, orciprenaline, fluticasone, ipratropium, dexamethasone, bambuterol, tiotropium, budesonide, fenoterol, clenbuterol, prednisolone, prednisone, prednylidene, methylprednisolone, formoterol, nedocromil, insulin, ipratropium bromide, tiotropium bromide, a cortisone preparation, or an atropine derivative.
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이 특허에 인용된 특허 (52)
Vlock David G. (12 Fifth Ave. New York NY 10011-8857), Amalgam capsule.
Rocchio, Michael J.; Stout, Gordon; Deming, Steve; Brannigan, Diane; Parks, Derrick J.; Ploeger, Dale, Apparatus and method for filling a receptacle with powder.
Grimberg Georges S. (123 rue de l\Universite\ 75007 Paris FRX), Medicament having a pediatric presentation for facilitating the ingestion thereof by a child.
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Birch Leslie William (Desborough EN) Dean Desmond Alfred (Beeston EN) Howell ; deceased Harry (LATE OF Castle Donnington EN BY Eunice Cockburn Gray ; executor), Method and device for dispensing medicament to the body.
Wittwer Fritz (Lupsingen CHX) Tomka Ivan (Lenzburg CHX) Bodenmann Hans-Ulrich (Mnchenstein CHX) Raible Thomas (Jona NJ CHX) Gillow Louis S. (Rockaway NJ), Method for forming pharmaceutical capsules from starch compositions.
Bodenmann Hans U. (Muenchenstein CHX) Van Herle Louis P. (Berchem-Antwerp BEX) Michel Luc Y. (Fegersheim-Ohnheim FRX) Pins Heinrich (Eberbach DEX) Martens Winand H. (Belsele BEX), Method for producing a joined capsule filled with viscous material.
Buddenbaum Harry C. (Indianapolis IN) Robison Robert L. (Greenwood IN), Pharmaceutical compositions for storage in plastic containers and process therefor.
Katano, Akira; Nakagawa, Yusuke; Kono, Shinichi; Doi, Kousuke, Positive photoresist composition and method of patterning resist thin film for use in inclined implantation process.
Kirk William F. (Loughborough GBX) Wass Anthony C. L. (Duddington GBX) Baum Eric A. (Bishops Stortford GBX) Tansey Ian P. (Barrow on Soare Loughborough GBX) Meredith William G. (Rothley GBX), Powder inhalation device.
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