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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0784708 (2010-05-21) |
등록번호 | US-8303643 (2012-11-06) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 574 |
A device and method are provided for spontaneous electrochemical production of therapeutic species, in vivo. An active metal is implanted in the tissue. The metal undergoes corrosion, thus acting as a reducing agent to constituents in the tissue, so as to cause these constituents to form the therape
A device and method are provided for spontaneous electrochemical production of therapeutic species, in vivo. An active metal is implanted in the tissue. The metal undergoes corrosion, thus acting as a reducing agent to constituents in the tissue, so as to cause these constituents to form the therapeutic agents.
1. A stent adapted to be implanted in a blood vessel comprising: a stent body comprising a biologically inert metal selected from the group consisting of platinum, palladium, iridium, gold, and alloys thereof; anda coating of an active metal adapted to corrode when implanted in the blood vessel, the
1. A stent adapted to be implanted in a blood vessel comprising: a stent body comprising a biologically inert metal selected from the group consisting of platinum, palladium, iridium, gold, and alloys thereof; anda coating of an active metal adapted to corrode when implanted in the blood vessel, the active metal comprising zinc or iron, wherein one or more portions of the stent body are uncoated to allow for direct exposure of the one or more portions of the stent body to body fluid when the stent is implanted within a body lumen, wherein the coating is upstream or downstream of at least one uncoated portion. 2. The stent of claim 1, wherein the active metal comprises zinc. 3. The stent of claim 1, wherein the active metal comprises iron. 4. The stent of claim 1, wherein the biologically inert metal comprises platinum. 5. The stent of claim 1, wherein the biologically inert metal comprises palladium. 6. The stent of claim 1, wherein the biologically inert metal comprises gold. 7. The stent of claim 1, wherein the active metal acts as an anode and the biologically inert metal acts as a cathode when the stent is implanted within a blood vessel. 8. The stent of claim 7, wherein the active metal and the biologically inert metal are both directly exposed to the flow of body fluid in a blood vessel when the stent is implanted in a blood vessel. 9. The stent of claim 1, wherein the stent comprises a body of the biologically inert metal and a coating of the active metal. 10. The stent of claim 9, wherein the coating of the active metal is a partial coating such that the active metal acts as an anode and uncoated portions of the body act as a cathode. 11. The stent of claim 10, wherein the uncoated portions of the body are upstream of the coated portions of the body. 12. The stent of claim 1, wherein the active metal is adapted to electrochemically convert, in a body fluid stream environment, at least one substance present in the body fluid into a therapeutic agent. 13. The stent of claim 12, wherein the at least one substance is a normal body fluid constituent. 14. The stent of claim 13, wherein the normal body fluid constituent is selected from the group consisting of water, moledular oxygen, nitrite and nitrite ions and L-arginine. 15. The stent of claim 12, wherein the at least one substance is a substance administered to the body. 16. The stent of claim 15, wherein the at least one substance is selected from the group consisting of nitrite ions, nitrate ions, and a combination thereof. 17. The stent of claim 12, wherein the therapeutic agent is an oxidizing agent. 18. The stent of claim 12, wherein the therapeutic agent is the vasodilating agent, nitric oxide. 19. A stent adapted to be implanted in a blood vessel comprising: a stent body comprising a biologically inert metal selected from the group consisting of palladium and alloys thereof; anda coating of an active metal adapted to corrode when implanted in the blood vessel, the active metal comprising iron, wherein one or more portions of the stent body are uncoated to allow for direct exposure of the one or more portions of the stent body to body fluid when the stent is implanted within a body lumen, wherein the coating is upstream or downstream of at least one uncoated portion.
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