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Method for ex-vivo organ care and for using lactate as an indication of donor organ status

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-001/02
출원번호 US-0790405 (2007-04-25)
등록번호 US-8304181 (2012-11-06)
발명자 / 주소
  • Hassanein, Waleed
  • Khayal, Tamer
  • Elbetanony, Ahmed
  • Lezberg, Paul
  • Cecere, Giovanni
  • Sousa, Dennis
  • Hansen, Elizabeth
출원인 / 주소
  • Transmedics, Inc.
대리인 / 주소
    Wilmer Cutler Pickering Hale and Dorr LLP
인용정보 피인용 횟수 : 27  인용 특허 : 84

초록

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the a

대표청구항

1. A method of evaluating an ex vivo heart for transplantation suitability comprising: a) placing a heart in a protective chamber of an organ care system,b) connecting the heart to a perfusion fluid circuit to perfuse fluid to the heart,c) pumping a perfusion fluid to the heart,d) monitoring lactate

이 특허에 인용된 특허 (84)

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이 특허를 인용한 특허 (27)

  1. Ritchie, Greg; Lambert, II, Vincent; Bringham, Richard; Sullivan, John; Hassanein, Waleed H., Aortic cannula for ex vivo organ care system.
  2. Anderson, Lisa M.; Judson, Jared Alden, Apparatus for oxygenation and perfusion of tissue for organ preservation.
  3. Judson, Jared Alden; Maier, Lisa Maria, Apparatus for oxygenation and perfusion of tissue for organ preservation.
  4. Hassanein, Waleed H.; Khuri, Shukri; Crittenden, Michael D.; Birjinuik, Vladimir, Compositions, methods and devices for maintaining an organ.
  5. Hassanein, Waleed H.; Khuri, Shukri; Crittenden, Michael D.; Birjinuik, Vladimir, Compositions, methods and devices for maintaining an organ.
  6. Hassanein, Waleed H.; Khuri, Shukri; Crittenden, Michael D.; Birjinuik, Vladimir, Compositions, methods and devices for maintaining an organ.
  7. Hassanein, Waleed H.; Khayal, Tamer I.; Elbetanony, Ahmed; Barnes, Jeff; Ritchie, Greg; Bringham, Richard; Anderson, Mark; Sullivan, John, Ex vivo organ care system.
  8. Anderson, Lisa Maria; Judson, Jared Alden, Methods and devices for preserving tissues.
  9. Anderson, Lisa Maria; Judson, Jared Alden, Methods and devices for preserving tissues.
  10. Anderson, Lisa Maria; Judson, Jared Alden, Methods and systems for assessing the suitability of an organ for transplant.
  11. Anderson, Lisa Maria; Judson, Jared Alden, Methods for evaluating the suitability of an organ for transplant.
  12. Anderson, Lisa Maria; Judson, Jared Alden; Edelman, William, System for hypothermic transport of biological samples.
  13. Anderson, Lisa Maria; Judson, Jared Alden, System for hypothermic transport of samples.
  14. Anderson, Lisa Maria; Judson, Jared Alden, System for hypothermic transport of samples.
  15. Fishman, Robert; Havener, Robert; Fattah, Ihab A.; Abdelazim, Anas; Newell, Scott; Bishop, Thomas H.; Khayal, Tamer I.; Kyi, Stanley; Taylor, Jr., Ron; Harriott, Doug; De Remer, Matthew; Murray, Paul; Sullivan, John; Anderson, Mark; Bringham, Richard; Van Driel, Michael; Hassanein, Waleed H., Systems and methods for ex vivo lung care.
  16. Fishman, Robert; Havener, Robert; Fattah, Ihab Abdel; Abdelazim, Anas; Newell, Scott; Bishop, Tom; Khayal, Tamer; Kyi, Stanley; Taylor, Ron; Harriott, Doug; De Remer, Matthew; Murray, Paul; Sullivan, John; Anderson, Mark; Bringham, Richard; Van Driel, Michael; Hassanein, Waleed, Systems and methods for ex vivo lung care.
  17. Fishman, Robert; Havener, Robert; Fattah, Ihab Abdel; Abdelazim, Anas; Newell, Scott; Bishop, Tom; Khayal, Tamer; Kyi, Stanley; Taylor, Ron; Harriott, Doug; De Remer, Matthew; Murray, Paul; Sullivan, John; Anderson, Mark; Bringham, Richard; Van Driel, Michael; Hassanein, Waleed, Systems and methods for ex vivo lung care.
  18. Fishman, Robert; Havener, Robert; Fattah, Ihab Abdel; Abdelazim, Anas; Newell, Scott; Bishop, Tom; Khayal, Tamer; Kyi, Stanley; Taylor, Ron; Harriott, Doug; De Remer, Matthew; Murray, Paul; Sullivan, John; Anderson, Mark; Bringham, Richard; Van Driel, Michael; Hassanein, Waleed, Systems and methods for ex vivo lung care.
  19. Hassanein, Waleed; Khayal, Tamer; Havener, Robert; Kyi, Stanley; Fattah, Ihab Abdel; Saleh, Hesham; Trachtenberg, Jon C., Systems and methods for ex vivo organ care.
  20. Hassanein, Waleed; Bringham, Richard; Cecere, Giovanni; Elbetanony, Ahmed; Fishman, Robert; Goff, Larry; Khayal, Tamer; Kyi, Stanley; Newell, Scott; Ochs, Burt; Sousa, Dennis; Taylor, Ronald; Rourke, Jonathan; Algamil, Hossam; Carpenter, David; Havner, Robert; Menn, Dmitri, Systems and methods for ex-vivo organ care.
  21. Hassanein, Waleed; Bringham, Richard; Cecere, Giovanni; Khayal, Tamer; Taylor, Ronald; Algamil, Hossam, Systems and methods for ex-vivo organ care.
  22. Hassanein, Waleed; Fishman, Robert; Kyi, Stanley; Newell, Scott; Ochs, Burt; Rourke, Jonathan; Havner, Robert, Systems and methods for ex-vivo organ care.
  23. Hassanein, Waleed; Khayal, Tamer; Elbetanony, Ahmed; Lezberg, Paul; Cecere, Giovanni; Sousa, Dennis; Hansen, Elizabeth, Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status.
  24. Hassanein, Waleed; Elbetanony, Ahmed; Bringham, Richard; Havener, Robert; Lambert, II, Vincent; Ochs, Burt, Systems for monitoring and applying electrical currents in an organ perfusion system.
  25. Hassanein, Waleed H.; Khayal, Tamer I.; Lezberg, Paul, Systems, methods, compositions and solutions for perfusing an organ.
  26. Hassanein, Waleed; Lezberg, Paul; Khayal, Tamer, Systems, methods, compositions and solutions for perfusing an organ.
  27. Judson, Jared Alden; Edelman, William; Schmieta, Gerd; Anderson, Lisa Maria, Transporter for a tissue transport system.
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