Resorbable nanoenhanced hemostatic structures and bandage materials
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61F-013/02
출원번호
US-0329431
(2008-12-05)
등록번호
US-8304595
(2012-11-06)
발명자
/ 주소
Daniels, R. Hugh
Dubrow, Robert S.
Enzerink, Robert
Li, Esther
Sahi, Vijendra
Goldman, Jay L.
Parce, J. Wallace
출원인 / 주소
Nanosys, Inc.
대리인 / 주소
Filler, Andrew L.
인용정보
피인용 횟수 :
3인용 특허 :
83
초록▼
Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and s
Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.
대표청구항▼
1. A hemostatic structure, comprising: a base structure that includes a first material; anda plurality of nanostructures incorporated with the base structure, wherein the nanostructures include at least one of nanofibers or nanorods;wherein the nanostructures comprise at least one semiconductor mate
1. A hemostatic structure, comprising: a base structure that includes a first material; anda plurality of nanostructures incorporated with the base structure, wherein the nanostructures include at least one of nanofibers or nanorods;wherein the nanostructures comprise at least one semiconductor material and are configured to induce hemostasis when the hemostatic structure is contacted with blood. 2. The hemostatic structure of claim 1, wherein the base structure includes a woven or nonwoven fiber of the first material. 3. The hemostatic structure of claim 2, wherein the first material is a natural fiber. 4. The hemostatic structure of claim 2, wherein the first material is a synthetic fiber. 5. The hemostatic structure of claim 2, wherein the fiber is a glass microfiber. 6. The hemostatic structure of claim 1, wherein the nanostructures include silicon nanowires. 7. The hemostatic structure of claim 6, wherein the silicon nanowires have a thin naturally occurring oxide shell layer. 8. The hemostatic structure of claim 1, wherein the nanostructures coat the base structure. 9. The hemostatic structure of claim 1, wherein the first material is resorbable. 10. The hemostatic structure of claim 1, wherein the first material includes cotton. 11. The hemostatic structure of claim 1, wherein the first material includes oxidized cellulose. 12. The hemostatic structure of claim 1, wherein the first material includes collagen. 13. The hemostatic structure of claim 1, wherein the first material includes a biologically-derived material. 14. The hemostatic structure of claim 1, wherein the first material is an organic or inorganic polymer. 15. The hemostatic structure of claim 1, wherein the hemostatic structure is a bandage. 16. The hemostatic structure of claim 1, wherein the base structure is a bandage. 17. A hemostat, comprising: a material; anda plurality of nanostructures comprising at least one semiconductor material, wherein the nanostructures include at least one of nanofibers, nanorods, or nanotubes;wherein the material and the nanostructures form a mixture. 18. The hemostat of claim 17, wherein the nanostructures include nanofibers. 19. The hemostat of claim 18, wherein the nanofibers are coated with silicon dioxide. 20. The hemostat of claim 18, wherein the nanofibers are potassium nanofibers. 21. The hemostat of claim 18, wherein the nanofibers are silicon nanofibers functionalized with potassium. 22. The hemostat of claim 17, wherein the material comprises chitosan. 23. The hemostat of claim 22, wherein the material comprises chitosan microparticles. 24. The hemostat of claim 17, wherein the material comprises biocompatible polymers. 25. A method for forming a hemostatic structure, comprising: incorporating nanostructures with a first material to form the hemostatic structure. 26. The method of claim 25, wherein said incorporating comprises: incorporating the nanostructures with a weave of fibers of the first material to form the hemostatic structure; andcoating the weave of fibers with the nanostructures to form the hemostatic structure; and wherein said coating comprises:sonicating a wafer coated with nanostructures in a liquid;filtering the sonicated nanostructures;suspending the filtered nanostructures in a liquid to form a nanostructure suspension;soaking the weave of fibers in the nanostructure suspension; anddrying the soaked weave of fibers.
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