초록 ▼

Methods and devices for selectively removing an agent from a physiological site, e.g., a physiological efferent fluid collection site, are provided. Aspects of the invention include fluid removal (e.g., aspiration) devices having a fluid removal element and a flow modulator positioned at a distal en

Methods and devices for selectively removing an agent from a physiological site, e.g., a physiological efferent fluid collection site, are provided. Aspects of the invention include fluid removal (e.g., aspiration) devices having a fluid removal element and a flow modulator positioned at a distal end of the fluid removal element. The flow modulator is configured to converge intersecting fluid flow paths into the fluid removal element. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.

대표청구항 ▼

1. A method for removing an agent from a physiological efferent fluid collection site of a living subject, said method comprising: introducing an aspiration device to a target site of said living subject at least proximal to said physiological efferent fluid collection site, wherein said aspiration

1. A method for removing an agent from a physiological efferent fluid collection site of a living subject, said method comprising: introducing an aspiration device to a target site of said living subject at least proximal to said physiological efferent fluid collection site, wherein said aspiration device comprises an aspiration element and a flow modulator at a distal end of said aspiration element that is configured to converge intersecting fluid flow paths so that the flow paths are focused into said aspiration element, wherein said flow modulator comprises an expandable frame of two or more longitudinal elements and an impermeable membrane positioned between said two or more longitudinal elements and partially covering the expandable frame, said flow modulator being configured to produce an asymmetric fluid barrier that is radially asymmetric upon expansion of said expandable frame; andactivating said aspiration device when said agent is at least predicted to be present in said target site to remove fluid comprising said agent from said subject;to selectively remove said agent from said physiological efferent fluid collection site. 2. The method according to claim 1, wherein said flow modulator is positioned at an intersection of two or more tributaries of said physiological efferent fluid collection site. 3. The method according to claim 2, wherein said method comprises expanding said frame at said intersection prior to activating said aspiration device. 4. The method according to claim 1, wherein said aspiration element and flow modulator are configured so that fluid flows past said aspiration element when said aspiration element is not activated. 5. The method according to claim 4, wherein said flow modulator comprises a flow outlet positioned downstream of said flow modulator. 6. The method according to claim 5, wherein said flow outlet is configured to allow bidirectional fluid flow. 7. The method according to claim 5, wherein said flow outlet is configured to allow unidirectional fluid flow. 8. The method according to claim 1, wherein said method further comprises detecting fluid flow in said efferent fluid collection site. 9. The method according to claim 8, wherein fluid flow is detected with a hemodynamic sensor. 10. The method according to claim 9, wherein said sensor is coupled to said flow modulator. 11. The method according to claim 1, wherein said method further comprises detecting said agent in said efferent fluid collection site with a detector. 12. The method according to claim 11, wherein said detector comprises a detection element that is introduced into said efferent fluid collection site through said aspiration element. 13. The method according to claim 12, wherein said method further comprises positioning said detector in said efferent fluid collection site with a positioning mechanism. 14. The method according to claim 13, wherein said positioning mechanism is operatively coupled to said flow modulator. 15. The method according to claim 13, wherein said positioning mechanism is operatively coupled to said detection catheter. 16. The method according to claim 1, wherein said physiological efferent fluid collection site is a vascular fluid collection site and said fluid is blood. 17. The method according to claim 16, wherein said vascular fluid collection site is a cardiovascular fluid collection site. 18. The method according to claim 17, wherein said cardiovascular fluid collection site is a coronary cardiovascular fluid collection site. 19. The method according to claim 18, wherein said coronary cardiovascular fluid collection site is a coronary sinus. 20. The method according to claim 1, wherein said physiological efferent fluid collection site is present in a mammal. 21. The method according to claim 20, wherein said mammal is a human. 22. The method according to claim 1, wherein said agent is a therapeutic agent. 23. The method according to claim 1, wherein said agent is a diagnostic agent. 24. The method according to claim 23, wherein said diagnostic agent is a contrast agent. 25. The method according to claim 1, wherein said method further comprises extracorporally separating agent from said fluid to produce an agent depleted fluid and then returning said agent depleted fluid to said body. 26. The method according to claim 1, wherein said method further comprises disposing of said fluid.