$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Compositions and methods for inhibiting vascular permeability

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/16
  • A61K-038/17
  • C07K-014/435
출원번호 US-0111776 (2011-05-19)
등록번호 US-8309519 (2012-11-13)
발명자 / 주소
  • Li, Dean
  • Jones, Christopher
  • London, Nyall
출원인 / 주소
  • University of Utah Research Foundation
대리인 / 주소
    Stoel Rives LLP
인용정보 피인용 횟수 : 0  인용 특허 : 250

초록

Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical

대표청구항

1. A method of inhibiting vascular permeability in tissue, comprising: administering to the tissue a ligand of roundabout-4 (Robo4) receptor;wherein the ligand of Robo4 is a Slit peptide comprising at least one of the amino acid sequence of SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41, SEQ ID NO: 42,

이 특허에 인용된 특허 (250)

  1. Tkachuk Zenovy (Kiev SUX) Kvasyuk Eugeny (Kiev SUX) Matsuka Gennady (Kiev SUX) Mikhailopulo Igor (Kiev SUX), (2′-5′) oligoadenylate analogues useful as inhibitors of host-v5.-graft response.
  2. Usman Nassim ; Karpeisky Alexander ; Beigelman Leonid ; Modak Anil, 2'-deoxy-2'-alkylnucleotide containing nucleic acid.
  3. Huynh Dinh Tam (Croissy/Seine FRX) Gouyette Catherine (Vanves FRX) Igolen Jean (Le Mesnil St. Denis FRX), 2,N6-disubstituted and 2,N6-trisubstituted adenosine-3′-phosphoramidites.
  4. Buhr Chris A. (Daly City CA) Matteucci Mark (Burlingame CA), 2\modified nucleoside and nucleotide compounds.
  5. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), 2′,5′-phosphorothioate oligoadenylates and their covalent conjugates with polylysine.
  6. Montgomery John A. (Birmingham AL) Secrist ; III John A. (Birmingham AL), 2′-deoxy-4′-thioribonucleosides and their antiviral activity.
  7. Usman Nassim (Boulder CO) Karpeisky Alexander (Boulder CO) Beigelman Leonid (Longmont CO) Modak Anil (Boulder CO), 2′deoxy-2′-alkylnucleotide containing nucleic acid.
  8. Joyce Gerald F. (Encinitas CA), T. thermophila group I introns that cleave amide bonds.
  9. Cook Philip D. (Carlsbad CA) Delecki Daniel J. (Radnor PA) Guinosso Charles (Vista CA), Acyclic nucleoside analogs and oligonucleotide sequences containing them.
  10. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
  11. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphorothioamidate oligonucleotide deratives.
  12. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Aminoalkylphosphotriester oligonucleotide derivatives.
  13. Lin Kuei-Ying (Fremont CA) Matteucci Mark (Burlingame CA), Anthraquinone-derivatives oligonucleotides.
  14. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of MAP kinase kinase 6 expression.
  15. Baker Brenda F. ; Cowsert Lex M., Antisense inhibition of TNFR1 expression.
  16. Monia Brett P. ; Cowsert Lex M., Antisense inhibition of human Smad1 expression.
  17. Bennett C. Frank ; Cowsert Lex M., Antisense modulation of Ship-2 expression.
  18. Kamiya Kinya,JPX ; Matsuda Yoko,JPX ; Uchida Kiyoshi,JPX, Antisense nucleic acid compounds inhibiting vascular endothelial growth factor.
  19. Power Christopher,CAX ; Mayne Michael B.,CAX, Antisense oligodeoxynucleotides regulating expression of TNF-.alpha..
  20. Goodnow ; Jr. Robert Alan ; Tam Steve Yik-Kai, Antisense oligomers.
  21. Lupski James R. (Houston TX) Katz Leonard (Waukegan IL), Antisense oligonucleotide antibiotics complementary to the macromolecular synthesis operon, methods of treating bacteria.
  22. Iversen Patrick L. (Omaha NE), Antisense oligonucleotide compositions for selectively killing cancer cells.
  23. Low Walter C. ; Flores Eric P. ; Hall Walter A. ; Chiang Lan ; Conrad John A., Antisense oligonucleotides and methods for treating central nervous system tumors.
  24. Switzer Christopher (Moreno Valley CA), Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides.
  25. Pietrzkowski Zbigniew ; Cieslak Dariusz ; Olbina Gordana, Antisense oligonucleotides for IL-8 and IL-8 receptor.
  26. Szyf Moshe,CAX ; Hofe Eric von, Antisense oligonucleotides having tumorigenicity-inhibiting activity.
  27. Cho-Chung Yoon S. (7017 Kenhill Rd. Bethesda MD 20817), Antisense oligonucleotides of human regulatory subunit RI-aof camp dependent pro.
  28. Cho-Chung Yoon S. (7017 Kenhill Rd. Bethesda MD 20817), Antisense oligonucleotides of human regulatory subunit RI-alpha of cAMP dependent protein kinases for the treatment of c.
  29. Capaccioli Sergio,ITX ; Morelli Susanna,ITX ; Nicolin Angelo,ITX, Antisense transcript associated to tumor cells having a T(14;18) translocation and oligodeoxynucleotides useful in the diagnosis and treatment of said tumor cells.
  30. Mett Helmut,DEX ; Haner Robert,CHX ; Dean Nicholas Mark, Antitumor antisense oligonucleotides.
  31. Stinchcomb Dan T. ; Jarvis Thale ; McSwiggen James, B7-1 targeted ribozymes.
  32. De Mesmaeker Alain (Kaenerkinden CHX) Lebreton Jacques (Marseilles FRX) Waldner Adrian (Allschwil CHX) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs.
  33. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Morvan Francois (Montpellier FRX), Backbone modified oligonucleotide analogs and solid phase synthesis thereof.
  34. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA) Vasseur Jean J. (San Marcos CA) Debart Francoise (Montpellier FRX), Backbone modified oligonucleotide analogues.
  35. Sanghvi Yogesh S. (San Marcos CA) Cook Phillip D. (Vista CA), Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling.
  36. Usman Nassim ; Beigelman Leonid ; McSwiggen James ; Karpeisky Alex, Base-modified enzymatic nucleic acid.
  37. Leumann Christian (Zurich CHX), Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates.
  38. Leumann Christian (Zurich CHX), Bicyclic nucleosides, oligonucleotides, process for their preparation and intermediates.
  39. Matteucci Mark D. (Burlingame CA) Cao Xiaodong (Carlsbad CA), Binding compentent oligomers containing unsaturated 3′,5′and 2′,5′linkages.
  40. Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same.
  41. Spielvogel Bernard F. (107 Wood Glen Dr. Cary NC 27511) Sood Anup (5041 Gatewood Dr. Durham NC 27712), Boronated phosphoramidate compounds.
  42. Stinchcomb Dan T. (Boulder CO) Draper Kenneth (Boulder CO) McSwiggen James (Boulder CO) Jarvis Thale (Boulder CO), C-myb targeted ribozymes.
  43. Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.
  44. Altmann Karl-Heinz (Basel CHX) Imwinkelried Rene (Brig-Glis CHX) Eschenmoser Albert (Kusnacht CHX), Carbocyclic nucleosides containing bicyclic rings, oligonucleotides therefrom, process for their preparation, their use.
  45. Usman Nassim ; Cedergren Robert J.,CAX ; Chartrand Pascal,CAX ; Harvey Stephen C., Catalytic DNA.
  46. Szostak Jack W. ; Cuenoud Bernard,CHX ; Huizenga David E., Catalytic DNA having ligase activity.
  47. Letsinger Robert L. (Wilmette IL), Cholesteryl modified oligonucleotides.
  48. Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent (Austin TX), Chromophore probe for detection of nucleic acid.
  49. Altman Sidney (Hamden MA) Forster Anthony C. (Boston MA) Guerrier-Takada Cecilia L. (New Haven CT), Cleavage of targeted RNA by RNAase P.
  50. Bertsch-Frank Birgit (Rheinfelden DEX) Klasen Claas-Juergen (Freigericht DEX) Lieser Thomas (Hapau DEX) Mueller Klaus (Hasselroth DEX) Bewersdorf Martin (Gelnhausen DEX), Coated sodium percarbonate particles, a process for their production and detergent, cleaning and bleaching compositions.
  51. Snitman David L. (Boulder CO), Compositions and methods for functionalizing nucleic acids.
  52. Cook Phillip D. (San Marcos CA) Teng Kelly (San Diego CA), Conjugated 4′-desmethyl nucleoside analog compounds.
  53. Levina Asya ; Zamecnik Paul C., Conjugates of minor groove DNA binders with antisense oligonucleotides.
  54. Linn C. Preston (Durham NC) Pitner J. Bruce (Durham NC) Mize Pat D. (Durham NC), Covalent cyanine dye oligonucleotide conjugates.
  55. Cook Phillip D. (Carlsbad CA) Baschang Gerhard (Bettingen CHX), Cyclobutyl oligonucleotide surrogates.
  56. Szostak Jack W. (Boston MA) Huizenga David E. (Winthrop MA), DNA aptamers and catalysts that bind adenosine or adenosine-5′-phosphates and methods for isolation thereof.
  57. Gold Larry (Boulder CO) Tasset Diane (Boulder CO 4), DNA ligands of thrombin.
  58. Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA) Kaiser ; Jr. Robert J. (Glendale CA), DNA-reporter conjugates linked via the 2′or 5′-primary amino group of the 5′-terminal nucleoside.
  59. Lizardi Paul M. (Colonia Rancho Cortez Cuernavaca MXX) Tyagi Sanjay (New York NY) Landegren Ulf D. (Uppsala SEX) Kramer Fred R. (Riverdale NY) Szostak Jack W. (Boston MA), Diagnostic assays and kits for RNA using RNA binary probes and a ribozyme ligase.
  60. Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) De Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel C, Dinucleoside phosphinates and their pharmaceutical compositions.
  61. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Konstanz DEX), Dual action 2′,5′-oligoadenylate antiviral derivatives and uses thereof.
  62. George Shaji T. (New York NY) Ma Michael (Roosevelt Island NY) Werner Martina (New York NY) Pace Umberto (Riverdale NY) Goldberg Allan R. (New York NY), EGS-mediated inactivation of target RNA.
  63. Suhadolnik Robert J. (Roslyn PA) Pfleiderer Wolfgang (Constance DEX), Encapsulated 2′,5′-phosphorothioate oligoadenylates.
  64. Brakel Christine L. (Brightwaters NY) Cook Alan F. (Cedar Groove NJ) Vuocolo Edmund (Bronx NY), End labeled nucleotide probe.
  65. Froehler Brian (Belmont CA) Matteucci Mark (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified purines.
  66. Froehler Brian (Belmont CA) Wagner Rick (Belmont CA) Matteucci Mark (Burlingame CA) Jones Robert J. (Millbrae CA) Gutierrez Arnold J. (Sandy Lane CA) Pudlo Jeff (Burlingame CA), Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines.
  67. Joyce Gerald F. ; Breaker Ronald R., Enzymatic DNA molecules.
  68. Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alexander ; Jarvis Thale ; Usman Nassim ; DiRenzo Anthony ; Wincott Francine, Enzymatic nucleic acids containing 5'-and/or 3'-cap structures.
  69. Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Exonuclease resistant terminally substituted oligonucleotides.
  70. Schneider Daniel J. ; Vanderslice Rebecca ; Gold Larry, Flow cell SELEX.
  71. Brush Charles K. (Whitefish Bay WI), Fluorescein labelled phosphoramidites.
  72. Ts'o Paul On-Pong ; Trapane Tina Lynn, Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidin.
  73. Draper Kenneth G. ; Chowrira Bharat ; McSwiggen James ; Stinchcomb Dan T. ; Thompson James D., HIV nef targeted ribozymes.
  74. Hampel Arnold E. ; Tritz Richard H., HIV targeted hairpin ribozymes.
  75. Hampel Arnold E. ; Tritz Richard H. ; Hicks Margaret F., HIV targeted hairpin ribozymes.
  76. Draper Kenneth G. (Boulder CO) Chowrira Bharat (Boulder CO) McSwiggen James (Boulder CO) Stinchcomb Dan T. (Boulder CO) Thompson James D. (Boulder CO), HIV targeted ribozymes.
  77. Chowrira Bharat ; McSwiggen James, Hairpin ribozymes.
  78. Chowrira Bharat ; McSwiggen James A., Hairpin ribozymes.
  79. Hampel Arnold E. ; Tritz Richard H. ; Hicks Margaret F., Hairpin ribozymes.
  80. Swiggen James A. (Solon OH) Mamone J. Anthony (Parma OH), Hammerhead ribozymes for preferred targets.
  81. Taira Kazunari (Tsukuba JPX) Oda Masanao (Tsukuba JPX) Shinshi Hideaki (Tsuchiura JPX) Furukawa Kensuke (Munakata JPX) Maeda Hidekatsu (Nagareyama JPX), Hammerhead ribozymes with enhanced stability provided by an additional 3′hairpin sequence.
  82. Sugiyama Hiroshi,JPX ; Hatano Ken,JPX ; Saito Isao,JPX ; Uchida Takayoshi,JPX ; Matsuda Yoko,JPX ; Uchida Kiyoshi,JPX, Hammerhead-like nucleic acid analogues and their synthesis.
  83. Cook Phillip D. (Carlsbad CA) Sanghvi Yogesh S. (Carlsbad CA), Heteroatomic oligonucleoside linkages.
  84. Teng Kelly (San Diego CA) Sanghvi Yogesh S. (San Marcos CA) Cook Phillip Dan (San Marcos CA), Heteroatomic oligonucleoside linkages.
  85. Pagratis Nikos ; Gold Larry, High affinity HKGF nucleic acid ligands and inhibitors.
  86. Toothman Penelope J. ; Ringquist Steven ; Gold Larry, High affinity TGF.beta. nucleic acid ligands and inhibitors.
  87. Pieken Wolfgang ; Tasset Diane ; Janjic Nebojsa ; Gold Larry ; Kirschenheuter Gary P., High affinity nucleic acid ligands containing modified nucleotides.
  88. Jayasena Sumedha ; Davis Kenneth A. ; Gold Larry, High affinity nucleic acid ligands of CD4.
  89. Rabin Ross S. ; Jayasena Sumedha D. ; Gold Larry, High affinity nucleic acid ligands of ICP4.
  90. Tasset Diane ; Pagratis Nikos ; Jayasena Sumedha ; Gold Larry, High affinity nucleic acid ligands of cytokines.
  91. Parma David H. ; Hicke Brian ; Bridonneau Philippe ; Gold Larry, High affinity nucleic acid ligands to lectins.
  92. Parma David H. ; Hicke Brian J. ; Bridonneau Philippe ; Gold Larry, High affinity nucleic acid ligands to lectins.
  93. Schneider Daniel J. ; Gold Larry ; Feigon Juli, High affinity ssDNA ligands of HIV-1 reverse transcriptase.
  94. Polisky Barry (Boulder CO) Jenison Robert D. (Boulder CO) Gold Larry (Boulder CO), High-affinity nucleic acid ligands that discriminate between theophylline and caffeine.
  95. Hampel Arnold (DeKalb IL) DiPaolo Joseph (Bethesda MD) Siwkowski Andrew M. (Sycamore IL) Galasinski Scott C. (Rockford IL), Human papilloma virus inhibition by a hairpin ribozyme.
  96. Swenson David H., Hyperstabilizing antisense nucleic acid binding agents.
  97. Veerapanane Dange ; Hamanaka Shoji,JPX ; Nozawa Iwao,JPX, Il-15 triplex oligonucleotides.
  98. Rogers Thomas E. (Manchester MO) Gray Steven H. (Ellisville MO) Devadas Balekudru (Chesterfield MO) Adams Steven P. (St. Charles MO), Improved probes using nucleosides containing 3-dezauracil analogs.
  99. Morgan Jeffrey R. (Brighton MA) Mulligan Richard C. (Cambridge MA), In vivo introduction and expression of foreign genetic material in epithelial cells.
  100. Goldberg Mark A. (Boston MA) Levy Andrew P. (Brookline MA), Induction of vascular endothelial growth factor (VEGF) by transition metals.
  101. Pietrzkowski Zbigniew ; Cieslak Dariusz ; Olbina Gordana, Inhibition of tumor growth by antisense oligonucleotides for IL-8 and IL-8 receptor.
  102. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
  103. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke She L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
  104. Cohen Jack S. (Bethesda MD) Neckers Len (Bethesda MD) Stein Cy (Gaithersburg MD) Loke Shee L. (Wheaton MD) Shinozuka Kazuo (Kazo JPX), Inhibitors for replication of retroviruses and for the expression of oncogene products.
  105. Burch Ronald M. (Silver Spring MD), Interleukin receptor expression inhibiting antisense oligonucleotides.
  106. Morgan Jeffrey R. (Brighton MA) Mulligan Richard C. (Cambridge MA), Introduction and expression of foreign genetic material in epithelial cells.
  107. Gold Larry (Boulder CO) Tasset Diane (Boulder CO), Ligands of thrombin.
  108. Long David M. (Department of Chemistry & Biochemistry ; University of Colorado ; Campus Box 215 Boulder CO 80309-0215) Uhlenbeck Olke C. (Department of Chemistry & Biochemistry ; University of Colora, Ligation with hammerhead ribozymes.
  109. Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Shrewsbury MA), Linear aminoalkylphosphoramidate oligonucleotide derivatives.
  110. Miller Paul S. (Baltimore MD) Ts\O Paul O. P. (Lutherville MD), Linkage of proteins to nucleic acids.
  111. Arnold ; Jr. Lyle J. (San Diego CA) Reynolds Mark A. (San Diego CA) Bhatt Ram S. (San Diego CA), Linking reagents for nucleotide probes.
  112. Ohtsuka Eiko (Sapporo JPX) Koizumi Makoto (Tokyo JPX), Looped, hairpin ribozyme.
  113. Thompson James D., Method and reagent for inhibiting P-glycoprotein (mdr-1-gene).
  114. Draper Kenneth G., Method and reagent for inhibiting hepatitis B virus replication.
  115. Draper Kenneth G., Method and reagent for inhibiting hepatitis C virus replication.
  116. Draper Kenneth G., Method and reagent for inhibiting herpes simplex virus replication.
  117. Schneider Daniel J. (Boulder CO) Gold Larry (Boulder CO) Feigon Juli (Los Angeles CA), Method for identification of high affinity DNA ligands of HIV-1 reverse transcriptase.
  118. Benner Steven A. (Hadlaubstrasse 151 CH-8006 Zurich CHX), Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases.
  119. Hogan Michael E. (The Woodlands TX) Kessler Donald J. (The Woodlands TX), Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming.
  120. Schmidt Francis J. ; Cho Bongrae,KRX ; Nicholas ; Jr. Hugh B., Method for obtaining RNA aptamers based on shape selection.
  121. Gray Donald M. ; Clark Chris L., Method for selectively ranking sequences for antisense targeting.
  122. Ensoli Barbara ; Gallo Robert C., Method for treating kaposi's sarcoma with antisense oligonucleotides.
  123. Magda Darren (Cupertino CA) Sessler Jonathan L. (Austin TX) Iverson Brent L. (Austin TX) Sansom Petra I. (Austin TX) Crofts Shaun P. (Campbell CA), Method of expanded porphyrin-oligonucleotide conjugate synthesis.
  124. Draper Kenneth G. ; Pavco Pamela ; McSwiggen James ; Gustofson John ; Stinchcomb Dan T., Method of reducing stromelysin RNA via ribozymes.
  125. Cook Phillip Dan (Vista CA) Teng Kelly (San Diego CA), Methods of making conjugated 4′desmethyl nucleoside analog compounds.
  126. Matteucci Mark (Burlingame CA) Jones Robert J. (Daly City CA) Munger John (San Francisco CA), Modified internucleoside linkages having one nitrogen and two carbon atoms.
  127. Pieles Uwe (Gttingen DEX) Englisch Uwe (Gttingen DEX) Cramer Friedrich (Gttingen DEX), Modified oligonucleotides.
  128. Beaton Graham (Boulder CO) Fisher Eric F. (Boulder CO), Modified oligonucleotides and intermediates useful in nucleic acid therapeutics.
  129. Scanlon Kevin J., Modulation of drug and radiation resistant genes.
  130. Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Multifunctional nucleic acid monomer.
  131. Cook P. Dan (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA) Manoharan Muthiah (Carlsbad CA), N-2 substituted purines.
  132. Chang Chu-An (Piedmont CA) Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith.
  133. Chang Chu-An (Piedmont CA) Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith.
  134. Eppstein Deborah A. (Menlo Park CA) Felgner Philip L. (Los Altos CA) Gadek Thomas R. (Oakland CA) Jones Gordon H. (Cupertino CA) Roman Richard B. (Fairhope AL), N[www 상세보기
  • Nelson Paul S. (Union City CA) Kent Mark A. (Sunnyvale CA), Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides.
  • Lin Kuei-Ying (Fremont CA) Matteucci Mark (Burlingame CA), Non-nucleoside linkers for convenient attachment of labels to oligonucleotides using standard synthetic methods.
  • Usman Nassim ; Wincott Francine ; Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alex, Non-nucleotide containing enzymatic nucleic acid.
  • Shizuya Hiroaki (1632 Indiana Ave. South Pasadena CA 91030) Millar Sharon L. (1825 Lanai St. West Covina CA 91792), Non-radioisotope tagging of fragments.
  • Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
  • Tullis Richard H. (Leucadia CA), Novel amphiphilic nucleic acid conjugates.
  • Nguyen Thanh T. (Tigy FRX) Helene Claude (Saint Cyr en Val FRX) Asseline Ulysse (La Source FRX), Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis a.
  • Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Nuclease resistant compounds.
  • Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression.
  • Bischofberger Norbert W. (San Carlos CA) Matteucci Mark D. (Burlingame CA), Nucleic acid intercalating agents.
  • Gold Larry ; Schmidt Paul G. ; Janjic Nebojsa, Nucleic acid ligand complexes.
  • Gold Larry ; Javasena Sumedha, Nucleic acid ligands that bind to and inhibit DNA polymerases.
  • Ramachandran Kuzhalmannam L. (Natick MA) Cate Richard L. (Plymouth MA), Nucleic acid probe linked to a label having a terminal cysteine.
  • Rokita Steven E. (Port Jefferson NY) Chatterjee Moneesh (Stony Brook NY), Nucleic acids labeled with naphthoquinone probe.
  • Haralambidis Jim (Victoria AUX), Nucleoside derivatives.
  • Klevan Leonard (Washington DC) Gebeyehu Gulilat (Silver Spring MD) Rao Prasad Y. (Damascus MD), Nucleotide analogs for nucleic acid labeling and detection.
  • Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Nucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides.
  • Usman Nassim (Boston MA) Cedergren Robert J. (Montreal CAX) Perreault Jean-Pierre (Rawdon CAX) Yang Jing-Hua (Montreal CAX) Rich Alexander (Cambridge MA), Nucleozymes.
  • Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기
  • Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
  • Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms.
  • Hecht Sidney M. (Charlottesville VA), Oligonucleotide N-alkylphosphoramidates.
  • Bischofberger Norbert (San Carlos CA) Kent Ken (Mountain View CA) Wagner Rick (Burlingame CA) Buhr Chris (Daly City CA) Lin Kuei-Ying (Fremont CA), Oligonucleotide analogs capable of passive cell membrane permeation.
  • Benner Steven A. (Grossmannstrasse 16 ; #7 CH-8049 Zurich CHX), Oligonucleotide analogs containing sulfur linkages.
  • Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
  • Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
  • Huie Edward M. (Wilmington DE) Trainor George L. (Wilmington DE), Oligonucleotide analogs with sulfamate linkages.
  • Weis Alexander Ludvik (Berwyn PA) Hausheer Frederick Herman (San Antonio TX) Chaturvedula Prasad Venkata Chala (Exton PA) Delecki Daniel Joseph (Radnor PA) Cavanaugh ; Jr. Paul Francis (West Chester , Oligonucleotide analogues containing phosphate diester linkage substitutes, compositions thereof, and precursor dinucleo.
  • Priest John H. (Everett WA), Oligonucleotide conjugates.
  • Miyoshi Kenichi (Hiroshima JPX) Fuwa Toru (Hiroshima JPX), Oligonucleotide derivatives.
  • Miyoshi Kenichi (Hiroshima JPX) Suzuki Masanori (Hiroshima JPX) Fuwa Toru (Hiroshima JPX), Oligonucleotide derivatives.
  • Miyoshi Kenichi (Hiroshima JPX) Fuwa Toru (Hiroshima JPX), Oligonucleotide derivatives and production thereof.
  • Chaturvedula Prasad Venkata Chala (Exton PA), Oligonucleotide dimers with amide linkages replacing phosphodiester linkages.
  • Buhr Chris A. (Daly City CA), Oligonucleotide having enhanced binding affinity.
  • Agrawal Sudhir (Shrewsbury MA) Tang Jin-Yan (Worcester MA), Oligonucleotide multiple reporter precursors.
  • Tullis Richard H. (La Jolla CA), Oligonucleotide therapeutic agent and method of making same.
  • Warren ; III Harold C. (Rush NY) Oakes Fred T. (Rochester NY), Oligonucleotide-enzyme conjugate that can be used as a probe in hybridization assays and polymerase chain reaction proce.
  • Hornes Erik (Oslo NOX) Korsnes Lars (Oslo NOX), Oligonucleotide-linked magnetic particles and uses thereof.
  • Haralambidis Jim (Box Hill South AUX) Tregear Geoffrey W. (Hawthorn AUX), Oligonucleotide-polyamide conjugates and methods of production and applications of the same.
  • Maag Hans (Menlo Park CA) Rose Samuel J. (Mountain View CA) Schmidt Beat (Baltschieder CHX), Oligonucleotides containing 4′-substituted nucleotides.
  • Gmeiner William H. (Omaha NE) Iversen Patrick L. (Omaha NE), Oligonucleotides containing 5-fluorouracil.
  • Froehler Brian (Belmont CA) Jones Robert J. (Daly City CA), Oligonucleotides containing 5-propynyl pyrimidines.
  • Cook Phillip D. (San Marcos CA) Ramasamy Kanda S. (Laguna Hills CA) Manoharan Muthiah (Carlsbad CA), Oligonucleotides containing N-2 substituted purines.
  • Cook Phillip D. (San Marcos CA) Hoke Glenn (Mt. Airy MD), Oligonucleotides having phosphorothioate linkages of high chiral purity.
  • Smith Lloyd M. (South Pasadena CA) Fung Steven (Palo Alto CA) Kaiser ; Jr. Robert J. (Glendale CA), Oligonucleotides possessing a primary amino group in the terminal nucleotide.
  • Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Oligonucleotides with cleavable sites.
  • Froehler Brian (Belmont CA), Oligonucleotides with inverted polarity.
  • Lebleu Bernard (Montpellier FRX) Bayard Bernard (Castelnau Le Lez FRX), Oligonucleotides with modified phosphate and modified carbohydrate moieties at the respective chain termini.
  • Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Oligonucleotides with selectably cleavable and/or abasic sites.
  • Imbach Jean-Louis (Montpellier FRX) Gosselin Gilles J. M. (Montpellier FRX), Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon.
  • Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Shaw Barbara R. (Durham NC), Oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
  • Barascut Jean-Louis (Combaillaux FRX) Imbach Jean-Louis (Montpellier FRX), Oligothionucleotides.
  • Joyce Gerald F. (Encinitas CA), Optimized catalytic DNA-cleaving ribozymes.
  • Prydz Hans Peter Blankenborg,NOX ; Brede Gaute,NOX, PSKH-1 ribozymes.
  • Eaton Bruce ; Gold Larry, Parallel SELEX.
  • Eaton Bruce ; Gold Larry, Parallel selex.
  • Meyer ; Jr. Rich B. (Woodinville WA) Gall Alexander A. (Bothell WA) Reed Michael W. (Seattle WA), Peptide linkers for improved oligonucleotide delivery.
  • Nielsen Peter E. (Hjortevanget 509 DK 2980 Kokkedal DKX) Buchardt Ole (Sondergardsvej 73 DK 3500 Vaerlose DKX) Egholm Michael (Johnstrup Alle 3 DK 1923 Frederiksberg DKX) Berg Rolf H. (Strandvaenget , Peptide nucleic acids.
  • Buchardt ; deceased Ole,DKX ; Buchardt ; legal representative by Dorte,DKX ; Egholm Michael ; Nielsen Peter Eigil,DKX ; Berg Rolf Henrik,DKX, Peptide nucleic acids having amino acid side chains.
  • Buchardt ; deceased Ole,DKX ; Buchardt ; representative by Dorte,DKX ; Egholm Michael ; Nielsen Peter Eigil,DKX ; Berg Rolf Henrik,DKX, Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility.
  • Misiura Konrad (Lodz PLX) Gait Michael (Cambridge GB3), Phosphoramidite derivatives, their preparation and the use thereof in the incorporation of reporter groups on synthetic.
  • Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Photolabile reagents for incorporation into oligonucleotide chains.
  • Yamane Akio (Hiroshima JPX) Kawasoe Tatsuro (Hiroshima JPX) Tsukumo Noriko (Hiroshima JPX) Miyoshi Kenichi (Hiroshima JPX), Poly-labelled oligonucleotide derivative.
  • Cook Philip D. (Carlsbad CA) Guinosso Charles J. (Carlsbad CA), Polyamine conjugated oligonucleotides.
  • Cook Philip D. (Carlsbad CA) Guinosso Charles J. (Carlsbad CA), Polyamine conjugated oligonucleotides.
  • Maddry Joseph A. (Birmingham AL) Reynolds Robert C. (Birmingham AL) Secrist John A. (Birmingham AL) Montgomery John A. (Birmingham AL) Crooks Peter A. (Lexington KY), Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages.
  • Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO) Brill Wolfgang (Freiburg DEX) Nielsen John (Horsholm DKX), Polynucleotide phosphorodithioate.
  • Caruthers Marvin H. (Boulder CO) Marshall William S. (Boulder CO), Polynucleotide phosphorodithioates.
  • Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use.
  • McGee Daniel Peter Claude (Boulder CO), Process for the preparation of 2′-O-alkyl purine phosphoramidites.
  • Weis Alexander L. (Berwyn PA) Saha Ashis K. (Frazer PA) Hausheer Frederick H. (San Antonio TX), Process of linking nucleosides with a siloxane bridge.
  • Hawkins Mary E. (Potomac MD) Pfleiderer Wolfgang (Konstanz MD DEX) Davis Michael D. (Rockville MD) Balis Frank (Bethesda MD), Pteridine nucleotide analogs as fluorescent DNA probes.
  • Matteucci Mark D. (Burlingame CA) Jones Robert J. (Millbrae CA) Lin Kuei-Ying (Fremont CA), Pyrimidine derivatives for labeled binding partners.
  • Acevedo Oscar L. (San Diego CA) Hebert Normand (San Marcos CA), Pyrrolidine-containing monomers and oligomers.
  • Torrence Paul F. ; Silverman Robert Hugh ; Cirino Nick Mario ; Li Guiying ; Xiao Wei, RNase L activators and antisense oligonucleotides effective to treat RSV infections.
  • Hobbs ; Jr. Frank W. (Wilmington DE), Reagents for the preparation of 5′-tagged oligonucleotides.
  • Cantor Glenn H. (NW. 517 Sunset Pullman WA 99163) Palmer Guy H. (NW. 815 Fisk Pullman WA 99163), Ribozyme-mediated inhibition of bovine leukemia virus.
  • Stinchcomb Dan T. ; McSwiggen James ; Newton Roger S. ; Ramharack Randy, Ribozymes targeted to APO(a) RNA.
  • Symonds Geoffrey P.,AUX ; Sun Lun-Quan,AUX, Ribozymes targeting retroviral packaging sequence expression constructs and recombinant retroviruses containing such con.
  • Keese Paul,AUX ; Stapper Marianne,AUX ; Perriman Rhonda,AUX, Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof.
  • DeYoung Mary Beth (Elmhurst IL) Siwkowski Andrew M. (Sycamore IL) Hampel Arnold E. (DeKalb IL), SArMV and sCYMVI hairpin ribozymes.
  • Szostak Jack W. (Boston MA) Lorsch Jon R. (Cambridge MA) Wilson Charles (Bonny Doon CA), Self-modifying RNA molecules and methods of making.
  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Sequence-specific binding polymers for duplex nucleic acids.
  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Sequence-specific binding polymers for duplex nucleic acids.
  • Werner Martina ; George Shaji T., Short external guide sequences.
  • Kool Eric T. (Rochester NY), Single-stranded circular oligonucleotides capable of forming a triplex with a target sequence.
  • Ruth Jerry L. (San Diego CA), Single-stranded labelled oligonucleotides of preselected sequence.
  • Ruth Jerry L. (San Diego CA), Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis.
  • Agrawal, Sudhir; Tang, Jinyan, Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling.
  • Van Ness Jeffrey (Bothell WA) Petrie Charles R. (Woodinville WA) Tabone John C. (Bothell WA) Vermeulen Nicolaas M. J. (Woodinville WA), Solid supports for nucleic acid hybridization assays.
  • Wu Yuan Min,CAX ; Nie Eileen Xiao-Feng,CAX, Solution hybridization of nucleic acids with antisense probes having modified backbones.
  • Gordon Julian (307 E. Sheridan Rd. Lake Bluft IL 60044) Minks Michael A. (Biochemistry Dept. ; University of the Witwatersrand ; 1 Jan Smuts Ave Johannesburg 2001 ZAX), Specific antibody to the native form of 2′5′-oligonucleotides, the method of preparation and the use as reagents in im.
  • Nyce Jonathan W., Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation.
  • Letsinger Robert L. (Wilmetter IL), Steroid modified oligonucleotides.
  • Cook Phillip Dan (Carlsbad CA) Manoharan Muthiah (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA), Substituted purines and oligonucleotide cross-linking.
  • Cook Phillip Dan (Carlsbad CA) Kawasaki Andrew Mamoro (Oceanside CA), Sugar modified oligonucleotides that detect and modulate gene expression.
  • Sproat Brian (Heidelberg DEX) Lamond Angus (Wiesenbach DEX) Paolella Giovanni (Gaiberg DEX), Synthetic catalytic oligonucleotide structures.
  • Heilig Joseph S. ; Gold Larry, Systematic evolution of ligands by exponential enrichment: tissue SELEX.
  • Jensen Kirk ; Chen Hang ; Morris Kevin N.,AUX ; Stephens Andrew ; Gold Larry, Systematic evolution of ligands by exponential enrichment: tissue selex.
  • Sullivan Sean ; Draper Kenneth ; Kisich Kevin ; Stinchcomb Dan T. ; McSwiggen James, TNF-.alpha. ribozymes.
  • Yuan Yan (New Haven CT) Guerrier-Takada Cecilia (New Haven CT) Altman Sidney (Hamden CT) Liu Fenyong (New Haven CT), Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence.
  • Yuan Yan ; Guerrier-Takada Cecilia ; Altman Sidney ; Liu Fenyong, Targeted cleavage of RNA using eukaryotic ribonuclease P and external guide sequence.
  • Yuan Yan ; Guerrier-Takada Cecilia ; Altman Sidney ; Liu Fenyong, Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences.
  • Hemmi Gregory W. (Sunnyvale CA) Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA), Texaphyrin compounds having improved functionalization.
  • Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA), Texaphyrin metal complexes having improved functionalization.
  • Sessler Jonathan L. (Austin TX) Mody Tarak D. (Sunnyvale CA) Hemmi Gregory W. (Sunnyvale CA) Kral Vladimir A. (Austin TX) Magda Darren (Cupertino CA), Texaphyrin-oligonucleotide conjugates.
  • Cook Phillip D. (Carlsbad CA) Manoharan Muthiah (Carlsbad CA), Thiol-derivatized nucleosides.
  • Dean Y. Li ; Mark T. Keating, Transgenic mouse with endogenous endoglin gene disruption.
  • Reed Michael W. (3575 NE. 180th Seattle WA 98105) Meyer ; Jr. Rich B. (15411 NE. 176th Pl. Woodinville WA 98072), Trifunctional intermediates for preparing 3′-tailed oligonucleotides.
  • Glazer Peter M., Triple-helix forming oligonucleotides for targeted mutagenesis.
  • Matsuo Ken-ichi,JPX ; Sugimoto Yoshikazu,JPX ; Masuko Norio,JPX ; Yamada Yuji,JPX, Triplex Oligonucleotides targeted to p120.
  • Kandimalla Ekambar (Worcester MA) Agrawal Sudhir (Shrewsbury MA), Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of p.
  • Summerton, James E.; Weller, Dwight D., Uncharged morpholino-based polymers having achiral intersubunit linkages.
  • Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages.
  • Aggarwal Bharat B. (Houston TX) Rando Robert F. (The Woodlands TX) Hogan Michael E. (The Woodlands TX), Uses of triplex forming oligonucleotides for the treatment of human diseases.
  • Janjic Nebojsa ; Gold Larry ; Schmidt Paul ; Vargeese Chandra, Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes.
  • AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

    AI-Helper 아이콘
    AI-Helper
    안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
    ※ AI-Helper는 부적절한 답변을 할 수 있습니다.

    선택된 텍스트