[특허]Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol

Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07D-263/08 C07C-233/00
출원번호	US-0056006 (2009-07-28)
등록번호	US-8314252 (2012-11-20)
국제출원번호	PCT/US2009/051893 (2009-07-28)
§371/§102 date	20110324 (20110324)
국제공개번호	WO2010/014566 (2010-02-04)
발명자 / 주소	Paquette, Leo A. Towson, James C.
출원인 / 주소	Intervet Inc.
대리인 / 주소	Kerwick, David J.
인용정보	피인용 횟수 : 0 인용 특허 : 47

초록

Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.

대표청구항 ▼

1. A process for preparing florfenicol comprising: a) reacting or its acid additional salt, wherein R2 is CHCl2 or phenyl, with in the presence of a solvent to form b) reducing the product resulting from step a) (with or without isolation) in the presence of a solvent to form c) fluorinating the product resulting from step b) (with or without isolation) in the presence of a solvent to form d) hydrolyzing the product resulting from step c) (with or without isolation) to form e) acylating the product resulting from step d) (with or without isolation) in the presence of a solvent and a base by a compound of the Formula CHCl2COOCH3 to form 2. The process of claim 1, wherein R2 is phenyl. 3. A process for preparing florfenicol comprising: a) reacting or its acid additional salt, with in the presence of a solvent to form b) reducing the product resulting from step a) (with or without isolation) in the presence of a solvent to form c) fluorinating the product resulting from step b) (with or without isolation) in the presence of a solvent to form d) selectively hydrolyzing the product resulting from step c) (with or without isolation) to form 4. A process for preparing florfenicol comprising: a) reducing (with or without isolation) in the presence of a solvent to form b) reacting or its acid additional salt, wherein R2 is CHCl2 or phenyl, with the product resulting from step a) to form c) fluorinating the product resulting from step b) (with or without isolation) in the presence of a solvent to form d) hydrolyzing the product resulting from step c) (with or without isolation) to form e) acylating the product resulting from step d) (with or without isolation) in the presence of a solvent and a base by a compound of the Formula CHCl2COOCH3 to form 5. The process of claim 4, wherein R2 is phenyl. 6. A process for preparing florfenicol comprising: a) reducing (with or without isolation) in the presence of a solvent to form b) reacting or its acid additional salt, with the product resulting from step a) to form c) fluorinating the product resulting from step b) (with or without isolation) in the presence of a solvent to form d) selectively hydrolyzing the product resulting from step c) (with or without isolation) to form

이 특허에 인용된 특허 (47)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol 원문보기

초록

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Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol 원문보기

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