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특허 상세정보

Local treatment of bone defects

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-038/29    A61K-038/00    C07K-014/635    A61P-019/08    A61P-019/10    A61P-005/18    C12N-015/00   
미국특허분류(USC) 514/011.8; 514/016.7; 514/016.9; 435/069.7; 424/425
출원번호 US-0326924 (2006-01-06)
등록번호 US-8318674 (2012-11-27)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 1  인용 특허 : 38
초록

A method of local treatment of specific bone defects such as osteoporosis or bone cysts comprises the step of local administration of a formulation comprising a fusion peptide containing a first domain comprising PTH or BMP 2 or BMP 7, and a second domain comprising a covalently crosslinkable substrate domain; and a material suitable of forming a biodegradable matrix suitable for cellular growth or in-growth, wherein the fusion peptide is covalently linked to the matrix. In one embodiment, the matrix contains one or more contrast agents, and is preferabl...

대표
청구항

1. A method of locally treating non-healthy bone areas in a patient, comprising locally administering to a site in bone in need of treatment only one bioactive factor,wherein the bioactive factor is provided in a formulation comprising a composition capable of forming a matrix at the site,wherein the bioactive factor is selected from the group consisting of parathyroid hormone (PTH1-84) or a parathyroid hormone (PTH) fragment selected from the group consisting of PTH1-34, PTH1-31 and PTH1-38; and a fusion peptide comprising (PTH1-84) or a PTH fragment se...

이 특허에 인용된 특허 (38)

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