|국가/구분||United States(US) Patent 등록|
|미국특허분류(USC)||034/286; 034/287; 034/288; 034/289; 034/295; 034/296; 424/046; 424/497; 134/172; 436/174; 514/002; 514/573; 510/295; 510/418|
|발명자 / 주소|
|출원인 / 주소|
|대리인 / 주소||
|인용정보||피인용 횟수 : 16 인용 특허 : 187|
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system...
1. A method of creating a powder, comprising the steps of: spraying a carrier liquid into a chamber, the carrier liquid containing a powder forming ingredient to form a flow of liquid droplets containing the carrier liquid and powder forming ingredient;entraining the flow of liquid droplets within a flow of coolant for sufficient time to freeze the liquid droplets into frozen particles, the flow of coolant entering the chamber around the flow of liquid droplets and frozen particles to screen the frozen particles from contacting walls of the chamber; andd...