초록 ▼

A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-

A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

대표청구항 ▼

1. A method of creating a powder, comprising the steps of: spraying a carrier liquid into a chamber, the carrier liquid containing a powder forming ingredient to form a flow of liquid droplets containing the carrier liquid and powder forming ingredient;entraining the flow of liquid droplets within a

1. A method of creating a powder, comprising the steps of: spraying a carrier liquid into a chamber, the carrier liquid containing a powder forming ingredient to form a flow of liquid droplets containing the carrier liquid and powder forming ingredient;entraining the flow of liquid droplets within a flow of coolant for sufficient time to freeze the liquid droplets into frozen particles, the flow of coolant entering the chamber around the flow of liquid droplets and frozen particles to screen the frozen particles from contacting walls of the chamber; anddrying the frozen particles to form a dry powder. 2. The method of claim 1 in which the powder forming ingredient is suspended or dissolved in the carrier liquid prior to spraying the carrier liquid into the chamber. 3. The method of claim 1 in which the flow of coolant is sprayed from a ring nozzle. 4. The method of claim 1 in which the flow of-coolant is injected through porous walls of the chamber. 5. The method of claim 1 in which the frozen particles are collected on a filter. 6. The method of claim 5 in which the frozen particles are substantially dried after being collected on the filter. 7. The method of claim 1 in which the flow of coolant has a temperature within a first temperature range during freezing of the liquid particles and a temperature warmer than the first temperature range during drying of the frozen particles. 8. The method of claim 1 in which the carrier liquid contains more than one powder forming ingredient. 9. The method of claim 1 in which the flow of coolant is co-current with the flow of liquid droplets. 10. The method of claim 1 in which spraying, entraining and freezing of the liquid droplets is carried out within the chamber. 11. The method of claim 10 in which deposition and drying of the frozen particles is carried out within the chamber. 12. The method of claim 1 further comprising depositing the frozen particles on a collector, the liquid droplets being frozen before deposition on the collector, and drying the frozen particles while the frozen particles are collected on the collector. 13. The method of claim 12 in which the collector is a filter at an exit to the chamber. 14. The method of claim 1 in which drying is carried out with a downward flow of coolant. 15. The method of claim 11 in which drying is carried out with a downward flow of coolant.