Methods of processing compositions containing microparticles
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/127
A61K-009/16
B32B-009/00
출원번호
US-0195005
(2008-08-20)
등록번호
US-8323685
(2012-12-04)
발명자
/ 주소
Piran, Uri
Mehr, Eugene
Brown, Larry R.
McGeehan, John K.
O'Connell, Ed
출원인 / 주소
Baxter International Inc.
대리인 / 주소
Marshall, Gerstein & Borun LLP
인용정보
피인용 횟수 :
3인용 특허 :
101
초록▼
Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the com
Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the composition while retaining at least the microparticles.
대표청구항▼
1. A method of separating a non-volatile material from microparticles comprising: providing a composition comprising a plurality of solid microparticles and at least one non-volatile material,providing a non-solvent comprising at least one non-aqueous liquid selected from the group consisting of tet
1. A method of separating a non-volatile material from microparticles comprising: providing a composition comprising a plurality of solid microparticles and at least one non-volatile material,providing a non-solvent comprising at least one non-aqueous liquid selected from the group consisting of tetrahydrofuran, 2-methyl-2-propanol, 2,3-dimethyl-2-butanol, 3-methyl-3-heptanol, 2-methyl-2-butanol, 2-butanone, 4-methyl-2-pentanone, 2-propanone, and combinations thereof and at least one aqueous liquid;exposing the composition to the non-solvent to form a mixture containing one or more liquid phases and the solid microparticles; andremoving at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the composition,wherein the non-volatile material is more soluble in the non-solvent than are the microparticles, andthe non-solvent is free of primary, linear alcohols and halogenated solvents. 2. The method of claim 1, wherein the microparticles are soluble in the aqueous liquid, but have less than 5 wt. % solubility in the non-solvent. 3. The method of claim 1, wherein the non-aqueous liquid is soluble in or miscible with the aqueous liquid. 4. The method of claim 1, wherein the solid microparticles are substantially insoluble in the at least one non-aqueous liquid. 5. The method of claim 1, wherein the exposing and/or removing steps comprise washing, diafiltration, filtration, dialysis, electrophoresis, or a combination thereof. 6. The method of claim 1, further comprising drying the microparticles to form a powder. 7. The method of claim 1, wherein the non-solvent has an oral LD50 in rats of greater than or equal to 1.6 g/kg by body weight. 8. The method of claim 1, wherein the non-solvent has a density less than or equal to 0.95 g/ml. 9. The method of claim 1, wherein the at least one non-volatile material is water-soluble. 10. The method of claim 1, wherein the non-solvent comprises 1% to 95% by volume of the at least one aqueous liquid. 11. The method of claim 1, wherein the non-solvent comprises water and a second fluid component selected from the group consisting of 2-methyl-2-butanol (t-amyl alcohol), glycerin, N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), acetone, carbonates, cyclic carbonates, hexamethylphosphoric triamide (HMPA), tetrahydrofuran (THF), N,N-dimethylacetamide, 2-pyrrolidone, N-methyl-2-pyrrolidone, tetramethyl urea, dioxane, dimethoxyethane, diethylene glycol dimethyl ether, ether, diisopropyl ether, 2-butanone (methyl ethyl ketone), 4-methyl-2-pentanone (isobutyl methyl ketone), 2-propanone, menthol, thymol, camphor, imidazole, coumarin, dimethylsulfone, urea, vanillin, camphene, salicylamide, pyridine, 2-aminopyridine, pyrimidine, piperidine, acetyl tributyl citrate, acetyl triethyl citrate, benzyl alcohol, butyrolactone, caprolactam, decylmethylsulfoxide, diacetin, diethyl phthalate, diethyl tartrate, dimethoxyethane, dimethylethylamide, 1-dodecylazacyclo-heptan-2-one, ethyl lactate, ethylene glycol, ethylene oxide, glycerol formal, glycofurol, propylene glycol, propylene oxide, silicone fluid, tetraglycol, triacetin, tributyl citrate, tributyrin, triethylcitrate, triethyl phosphate, and combinations thereof. 12. The method of claim 1, wherein the non-solvent comprises at least 40% by volume of 2-methyl-2-propanol. 13. The method of claim 1, wherein the solid microparticles comprise an active agent. 14. The method of claim 1, wherein the solid microparticles comprise at least one bioactive macromolecule on an outer surface of the solid microparticle. 15. The method of claim 14, wherein the at least one bioactive macromolecule is selected from the group consisting of carbohydrates, peptides, proteins, vectors, nucleic acids, complexes thereof, conjugates thereof, and combinations thereof. 16. The method of claim 1, wherein the solid microparticles comprise a carrier macromolecule. 17. The method of claim 1, wherein the at least one non-volatile material is selected from the group consisting of nonionic polyethers, nonionic copolyethers, nonionic polyesters, nonionic copolyesters, nonionic polyether-polyester copolymers, non-ionic vinyl polymers, non-ionic pyrrolidone-containing polymers, non-ionic polymeric carbohydrates, derivatives and salts of the foregoing materials, and combinations thereof. 18. The method of claim 1, wherein the microparticles are amorphous, spherical, or both. 19. The method of claim 1 wherein the non-solvent is a single-phase mixture comprising at least two liquids. 20. The method of claim 1, further comprising isolating the microparticles. 21. The method according to claim 20, further comprising lyophilizing the isolated microparticles. 22. The method according to claim 20, further comprising passing humidified nitrogen over the isolated microparticles. 23. The method of claim 1, wherein the composition is a multi-phasic dispersion comprising dispersed and continuous phases, the dispersion comprising the solid microparticles, the at least one non-volatile material, and a solvent. 24. The method of claim 23, wherein the solvent is soluble in or miscible with the non-solvent. 25. A method of separating a non-volatile material from microparticles comprising: providing a composition comprising a plurality of solid microparticles and at least one non-volatile material,providing a non-solvent comprising 2-methyl-2-propanol;exposing the composition to the non-solvent to form a mixture containing one or more liquid phases and the solid microparticles; andremoving at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the composition,wherein the non-volatile material is more soluble in the non-solvent than are the microparticles. 26. The method of claim 25, wherein the non-solvent further comprises water. 27. The method of claim 25, wherein the microparticles have less than 5 wt. % solubility in the non-solvent. 28. The method of claim 27, wherein the solid microparticles are substantially insoluble in 2-methyl-2-propanol. 29. The method according to claim 27, wherein the composition is a multi-phasic dispersion comprising dispersed and continuous phases, the dispersion comprising the solid microparticles and at least one of a non-volatile material and a solvent. 30. The method of claim 29, wherein the solvent is soluble in or miscible with the non-solvent. 31. A method of separating a non-volatile material from microparticles comprising: providing a composition comprising a plurality of solid microparticles, water, and at least one non-volatile material,providing a non-solvent comprising at least one non-aqueous liquid and at least one aqueous liquid;exposing the composition to the non-solvent to form a mixture containing one or more liquid phases and the solid microparticles; andremoving at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material and at least a portion of the water from the composition,wherein the non-volatile material is more soluble in the non-solvent than are the microparticles, andthe at least one non-aqueous liquid is selected from the group consisting of tetrahydrofuran, 2-methyl-2-propanol, 2,3-dimethyl-2-butanol, 3-methyl-3-heptanol, 2-methyl-2-butanol, 2-butanone, 4-methyl-2-pentanone, 2-propanone, and combinations thereof. 32. The method of claim 31, wherein the microparticles have less than 5 wt. % solubility in the non-solvent. 33. The method of claim 31, wherein the solid microparticles are substantially insoluble in the at least one non-aqueous liquid. 34. The method according to claim 31, wherein the composition is a multi-phasic dispersion comprising dispersed and continuous phases, the dispersion comprising the solid microparticles and at least one of a non-volatile material and a solvent. 35. The method of claim 34, wherein the solvent is soluble in or miscible with the non-solvent. 36. The method of claim 1, wherein the microparticles comprise a bioactive macromolecule having a tertiary structure.
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Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
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Onda Mitsuhiko,JPX ; Lvov Yuri,JPX ; Ariga Katsuhiko,JPX ; Kunitake Toyoki,JPX, Method for the preparation of an immobilized protein ultrathin film reactor and a method for a chemical reaction by using an immobilized protein ultrathin film reactor.
Gupta, Ram B.; Chattopadhyay, Pratibhash, Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer.
Jones David Hugh,GBX ; Farrar Graham Henry,GBX ; Clegg James Christopher Stephen,GBX, Method of making microencapsulated DNA for vaccination and gene therapy.
Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Eldridge John H. (Birmingham AL) Staas Jay K. (Birmingham AL) Hollingshead Melinda G. (Birmingham AL) Shannon William M. (Birmingham A, Method of potentiating an immune response.
Boyes Robert N. (St. Albans AL GB2) Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Pledger Kenneth L. (Huntsville AL), Pharmaceutical formulations comprising microcapsules.
DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
Cha Younsik (Salt Lake City UT) Choi Young Kweon (Salt Lake City UT) Pai Chaul Min (Taejon KRX), Preparation of peptide containing biodegradable microspheres by melt process.
Margolin, Alexey L.; Khalaf, Nazar K.; St. Clair, Nancy L.; Rakestraw, Scott L.; Shenoy, Bhami C., Stabilized protein crystals formulations containing them and methods of making them.
Park, Jin Kyu; Park, Mork Soon; Kim, Dong Seon; Lim, Il Ho; Jee, Ung Kil; Myung, Pyung Keun; Kim, San Beom; Jung, Goo Young, Sustained release microparticle and method for preparing the same.
Reid Robert H. (Kensington MD) Boedeker Edgar C. (Chevy Chase MD) van Hamont John E. (Shape MD BEX) Setterstrom Jean A. (Takoma Park MD), Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompa.
Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
Johnson, Greg S.; Subramaniam, Bala; Niu, Fenghui; Espinosa, Jahna C.; Decedue, Charles J.; Clapp, Gary E.; Sittenauer, Jacob M., Equipment assembly for and method of processing particles.
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