초록 ▼

A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify

A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture.

대표청구항 ▼

1. Filtration media comprising: a) a nonwoven substrate having average fiber diameter of 1 to 6 micrometers, and a void volume of 50 to 95%, a tensile strength of at least 4.0 Newtons prior to grafting and a polymer grafted to the surface of the nonwoven substrate wherein the grafted polymer compris

1. Filtration media comprising: a) a nonwoven substrate having average fiber diameter of 1 to 6 micrometers, and a void volume of 50 to 95%, a tensile strength of at least 4.0 Newtons prior to grafting and a polymer grafted to the surface of the nonwoven substrate wherein the grafted polymer comprises polymerized monomer units of: a) 80 to 98 wt. % of grafting aminoalkyl (meth)acryloyl monomers,b) 2 to 20 wt. % of grafting poly(alkylene oxide) monomers;c) 0 to 10 wt. % of second hydrophilic monomers. 2. The filtration media of claim 1 wherein the nonwoven substrate has a surface area of 15 to 50 m2 per square meter of nonwoven substrate. 3. The filtration media of claim 1 wherein the nonwoven substrate has a mean pore size of 1-40 microns according to ASTM F 316-03 5. 4. The filtration media of claim 1 wherein the nonwoven substrates have a solidity of less than 20%. 5. The filtration media of claim 1 wherein the weight of the grafted polymer is 0.5 to 5 times the weight of the nonwoven substrate. 6. The filtration media of claim 1 wherein the nonwoven substrate is prepared from a hydrophilic thermoplastic polymer. 7. The filtration media of claim 1 wherein the grafted polymer is of the formula. -(MNR4+)w-(MPEG)x-(Mc)y wherein-(MNR4+)w- represent the residue of the grafted aminoalkyl (meth)acryloyl monomer having w polymerized monomer units where w is at least 2,-(MPEG)x represents the polymerized poly(alkylene oxide) monomer having x polymerized monomer units, where x may be zero;-(Mc)y represents the polymerized hydrophilic monomer having y polymerized monomer units, where y may be zero. 8. The filtration media of claim 7 wherein the grafted polymer is a random or block copolymer. 9. The filtration media of claim 1 wherein the grafted polymer is uncrosslinked grafted brush polymer. 10. The filtration media of claim 1 wherein the nonwoven substrate has a basis weight of 10 to 400 g/m2. 11. The filtration media of claim 1 wherein the nonwoven substrate is a nylon nonwoven substrate. 12. The filtration media of claim 1 wherein the nonwoven substrate is a polyamide nonwoven substrate. 13. The filtration media of claim 1 wherein said polymer further comprises poly(alkylene oxide) monomer units grafted to the surface of the nonwoven substrate. 14. The filtration media of claim 1 wherein the polymer grafted to the surface of the nonwoven substrate consists essentially of aminoalkyl (meth)acryloyl monomer units, and said nonwoven substrate is a polyolefin nonwoven substrate. 15. A filter device comprising a fluid inlet;a fluid outlet; anda filter media fluidly connecting the fluid inlet and the fluid outlet;wherein the filter media comprises the grafted nonwoven substrate of claim 1. 16. The filter device of claim 15 wherein the filter media further comprises a microporous membrane layer positioned downstream of the grafted nonwoven substrate. 17. The filter device of either of claim 15 wherein the filter media comprises a plurality of pleats. 18. The filter device of claim 15 further comprising a filter capsule; anda filter cap connected to the filter capsule;wherein the filter cap comprises the fluid inlet and the fluid outlet, and wherein the filter media is encapsulated in the filter capsule. 19. The filter device of claim 18 wherein the filter media further comprises a microporous membrane layer positioned downstream of the grafted nonwoven substrate. 20. The filter device of any of claim 18 wherein the filter media is formed into a first media cylinder comprising a plurality of pleats. 21. The filter device of claim 20 further comprising a second media cylinder positioned within the first media cylinder, the second media cylinder comprising a second filter media comprising a plurality of pleats. 22. The filter device of claim 18 further comprising a core, wherein the filter media is spirally wound about the core.