[특허]Compositions that include a hydrophobic compound and a polyamino acid conjugate

Compositions that include a hydrophobic compound and a polyamino acid conjugate 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/00
출원번호	US-0475672 (2012-05-18)
등록번호	US-8329199 (2012-12-11)
발명자 / 주소	Van, Sang Song, Yucheng Wang, Xinghe Hou, Zheng Feng, Zhongling Zhao, Gang Yu, Lei
출원인 / 주소	Nitto Denko Corporation
대리인 / 주소	Knobbe Martens Olson & Bear LLP
인용정보	피인용 횟수 : 0 인용 특허 : 78

초록

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

대표청구항 ▼

1. A composition comprising a first anticancer drug, a second anticancer drug and a polymer conjugate, wherein: the polymer conjugate comprises a polymeric matrix that non-covalently entraps at least a portion of the first anticancer drug therein;the polymer conjugate comprises a recurring unit of the formula (I): wherein:one of R1 and R2 is the second anticancer drug; andthe other one of R1 and R2 is hydrogen or an alkali metal. 2. The composition of claim 1, wherein the polymer conjugate further comprises a recurring unit of the formula (II): wherein each R3 and each R4 are each independently hydrogen or an alkali metal. 3. The composition of claim 1, wherein the polymer conjugate further comprises a recurring unit of the formula (III): wherein each R7 is hydrogen or an alkali metal. 4. The composition of claim 3, wherein the polymer conjugate includes include about 1 mole % to about 50 mole % of the recurring unit of formula (III) based on the total moles of recurring units of formulae (I) and (III). 5. The composition of claim 1, wherein the first anticancer drug has a chemical structure that is the same as that of the second anticancer drug. 6. The composition of claim 1, wherein the first anticancer drug and the second anticancer drug are independently selected from the group consisting of a taxane, a camptotheca, and an anthracycline. 7. The composition of claim 6, wherein the first anticancer drug and the second anticancer drug is a taxane. 8. The composition of claim 7, wherein the first anticancer drug and the second anticancer drug is a paclitaxel. 9. The composition of claim 2, wherein the number of recurring units of the formula (I) and the number of recurring units of formula (II) in the polymer conjugate are each independently in the range of from about 50 to about 5,000. 10. The composition of claim 2, wherein the number of recurring units of the formula (I) and the number of recurring units of formula (II) in the polymer conjugate are each independently in the range of from about 100 to about 2,000. 11. The composition of claim 2, wherein the polymer conjugate consists of a recurring unit of formula (I) and a recurring unit of formula (II). 12. The composition of claim 1, wherein the first anticancer drug is present in an amount in the range of about 5% to about 40% (weight/weight) based on the mass ratio of the first anticancer drug to the combined weight of the first anticancer drug and the polymer conjugate. 13. The composition of claim 1, wherein the first anticancer drug is present in an amount in the range of about 10% to about 30% (weight/weight) based on the mass ratio of the first anticancer drug to the combined weight of the first anticancer drug and the polymer conjugate. 14. The composition of claim 1, wherein the polymer conjugate comprises an amount of the second anticancer drug in the range of about 5% to about 40% (weight/weight) based on the mass ratio of the second anticancer drug to the combined weight of the first anticancer drug and the polymer conjugate. 15. The composition of claim 1, wherein the polymer conjugate comprises an amount of the second anticancer drug in the range of about 10% to about 30% (weight/weight) based on the mass ratio of the second anticancer drug to the combined weight of the first anticancer drug and the polymer conjugate. 16. A method of making the composition of claim 1, comprising the steps of: at least partially dissolving the polymer conjugate in a solvent; andintermixing the first anticancer drug with the at least partially dissolved polymer conjugate to form a mixture. 17. A method of treating, ameliorating or diagnosing a disease or condition, comprising administering an effective amount of the composition of claim 1 to a mammal in need thereof. 18. The method of claim 17, wherein the disease or condition is selected from the group consisting of lung cancer, breast cancer, colon cancer, ovarian cancer, prostate cancer, and melanoma. 19. The method of claim 17, wherein the disease or condition is melanoma. 20. The method of claim 17, wherein the composition is administered intravenously.

이 특허에 인용된 특허 (78)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Compositions that include a hydrophobic compound and a polyamino acid conjugate 원문보기

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Compositions that include a hydrophobic compound and a polyamino acid conjugate 원문보기

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