초록 ▼

A fungus treatment composition used to deliver active drugs trans-nail as well as a method for producing the fungus treatment composition, which may contain up to 50% additive ingredients. Preferred embodiments of the invention may include fungus treatment compositions which provide high nail penetr

A fungus treatment composition used to deliver active drugs trans-nail as well as a method for producing the fungus treatment composition, which may contain up to 50% additive ingredients. Preferred embodiments of the invention may include fungus treatment compositions which provide high nail penetrating power, which have antifungal agents, which have antifungal essential oils, which have optimum drying and barrier properties, which have pharmaceutically elegant properties, or most preferably an embodiment having a total combination thereof.

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1. A fungus treatment composition consisting of: a smectite clay;a water-miscible solvent;a water-soluble polymer;an antifungal agent;a penetration enhancer; andan antifungal essential oil;wherein the penetration enhancer is a compound selected from the group consisting of: from about 0.01 percent t

1. A fungus treatment composition consisting of: a smectite clay;a water-miscible solvent;a water-soluble polymer;an antifungal agent;a penetration enhancer; andan antifungal essential oil;wherein the penetration enhancer is a compound selected from the group consisting of: from about 0.01 percent to about 0.09 percent of acetylcysteine, from about 1.0 percent to about 20 percent of allantoin, from about 1.0 percent to about 10 percent of sodium thioglycolate, and from about 0.1 percent to about 0.9 percent of urea, or a mixture thereof; andwherein the antifungal essential oil is from about 1 percent to about 10 percent and is a reagent selected from the group consisting of: a phenol, a terpenic alcohol, and an aromatic aldehyde, or a mixture thereof. 2. The fungus treatment composition of claim 1, wherein the smectite clay consists of montmorillonite or bentonite. 3. The fungus treatment composition of claim 1, wherein the water-miscible solvent is selected from the group consisting of: ethylene glycol, 1,2-propylene glycol, 1,3-propanediol, 1,2-butylene 2,3-butylene glycol, 1,4-butanediol, 1,2-hexylene glycol, diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, glycerin, trimethylolpropane, pentaerythritol, sorbitol, diethyl carbonate, diisopropyl carbonate, dibutyl carbonate, ethylene carbonate, propylene carbonate, 1,2-butylene carbonate, 2,3-butylene carbonate, methanol, ethanol, 1-propanol, 2-propanol, 2-methyl-1-propanol, 1-butanol, 2-butanol, 2-methyl-2-propanol, 2-propene-1-ol, 2-propyn-1-ol, 2-methoxy-1-ethanol, 1-methoxy-2-propanol, and 2-methoxy-1-propanol, or a mixture thereof. 4. The fungus treatment composition of claim 1, wherein said water-miscible solvent is in an amount ranging from about 5 percent to about 30 percent. 5. The fungus treatment composition of claim 1, wherein the water-soluble polymer consists of a hydroxypropylcellulose. 6. The fungus treatment composition of claim 1, wherein the antifungal agent consists of clioquinol, haloprogin, miconazole nitrate, povidone-iodine, tolnaftate, undecylenic acid, calcium undecylenate, copper undecylenate, or zinc undecylenate. 7. The fungus treatment composition of claim 1, wherein said antifungal agent is in an amount ranging from about 1.0 percent to about 25 percent. 8. A method of testing nail penetration of an active drug in the fungus treatment composition of claim 1 comprising: using Franz diffusion cells and nail pieces to measure the active drug penetration from the fungus treatment composition.