초록 ▼

Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invent

Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

대표청구항 ▼

1. An applicator comprising a housing and a nozzle assembly; wherein (i) the housing comprises a first barrel, comprising a first diameter, a first end, and a second end;a first internal chamber, comprising a proximal end and a distal end;a second internal chamber, comprising a proximal end and a di

1. An applicator comprising a housing and a nozzle assembly; wherein (i) the housing comprises a first barrel, comprising a first diameter, a first end, and a second end;a first internal chamber, comprising a proximal end and a distal end;a second internal chamber, comprising a proximal end and a distal end;a first floating plunger, located within the first barrel and under pressure movable therethrough, separating the first internal chamber from the second internal chamber, thereby forming the distal end of the first internal chamber, and the proximal end of the second internal chamber;a first plunger, comprising a first end and a second end, the second end of the first plunger is located at least partially within the first end of the first barrel and under pressure movable therethrough, thereby forming the proximal end of the first internal chamber;a first fluid bypass, located on the first barrel, external to the second internal chamber;a first piercable barrier, located at the distal end of the second internal chamber;a second barrel comprising a second diameter, a first end, and a second end;a third internal chamber, comprising a proximal end and a distal end;a fourth internal chamber, comprising a proximal end and a distal end;a second floating plunger, located within the second barrel and under pressure movable therethrough, separating the third internal chamber from the fourth internal chamber, thereby forming the distal end of the third internal chamber, and the proximal end of the fourth internal chamber;a second plunger, comprising a first end and a second end, the second end of the second plunger is located at least partially within the first end of the second barrel and under pressure movable therethrough, thereby forming the proximal end of the third internal chamber;a second fluid bypass, located on the second barrel, external to the fourth internal chamber;a second piercable barrier, located at the distal end of the fourth internal chamber;(ii) the nozzle assembly comprises a first inlet and a first piercer, wherein the first piercer is suitably positioned to pierce the first piercable barrier, and thereby connect the first inlet to the second internal chamber; and thea second inlet and a second piercer, wherein the second piercer is suitably positioned to pierce the second piercable barrier, and thereby connect the second inlet to the fourth internal chamber;a gas inlet; andan outlet in fluid communication with the first inlet, the second inlet and the gas inlet. 2. The applicator of claim 1, wherein the applicator further comprises a drive train and a locking mechanism; the drive train comprises a motor and a gear train, wherein the motor is connected to the gear train; the gear train is attached to the first end of the first plunger; and the gear train is attached to the first end of the second plunger; andthe lock mechanism is initially positioned to prevent the housing from substantially moving towards the nozzle assembly, thereby initially preventing the first piercer from piercing the first piercable barrier and initially preventing the second piercer from piercing the second piercable barrier. 3. The applicator of claim 2, further comprising a trigger; wherein activating the trigger starts the drive train, thereby compressing the first plunger and the second plunger and opening the first fluid bypass and the second fluid bypass. 4. The applicator of claim 1, wherein the applicator body further comprises a liquid in the first internal chamber; and the liquid is a buffer. 5. The applicator of claim 1, wherein the applicator body further comprises a liquid in the third internal chamber; and the liquid is a buffer. 6. The applicator of claim 1, wherein the applicator body further comprises a viscous liquid in the second internal chamber; and the viscous liquid comprises a polyalkyleneimine. 7. The applicator of claim 1, wherein the applicator body further comprises a solid in the fourth internal chamber; and the solid comprises an activated PEG. 8. The applicator of claim 1, wherein the housing further comprises a first pressure valve, located on the first barrel, external to the second internal chamber; and a second pressure valve, located on the second barrel, external to the fourth internal chamber. 9. The applicator of claim 1, wherein the housing further comprises a first hydrophobic filter, located at or near the distal end of the second internal chamber; and a second hydrophobic filter, located at or near the distal end of the fourth internal chamber. 10. The applicator of claim 1, wherein the housing further comprises a first check valve, located at or near the distal end of the second internal chamber; and a second check valve, located at or near the distal end of the fourth internal chamber. 11. The applicator of claim 1, wherein the nozzle is designed so that gas entering the gas inlet combines with material from the first inlet before the resulting mixture combines with material from the second inlet; or wherein the nozzle is designed so that gas entering the gas inlet combines with material from the second inlet before the resulting mixture combines with material from the first inlet. 12. The applicator of claim 1, wherein the nozzle further comprises a brush, a sponge, a foam swab, a porous plastic component, a duck bill tip, a textile mitt or a spray tip affixed to the outlet. 13. The applicator of claim 1, wherein the nozzle further comprises a tubular fitment comprising two open ends; one end of the tubular fitment is affixed to the outlet; and the tubular fitment is adapted to pass through an endoscope or a laparoscope; or the nozzle further comprises a tubular fitment comprising two open ends; one open end of the tubular fitment is affixed to the outlet and the other open end of the fitment has a flattened opening relative to the open end affixed to the outlet;or the nozzle further comprises a tubular fitment comprising two open ends; one open end of the tubular fitment is affixed to the outlet and the other open end of the fitment comprises a protruding spatula-like piece. 14. The applicator of claim 1, further comprising an atomization fluid pathway; wherein said atomization fluid pathway is configured to expel any material in the nozzle out of the nozzle through the outlet. 15. The applicator of claim 1, further comprising an air pump. 16. The applicator of claim 15, wherein the air pump is contained within an air pump housing which further comprises batteries and an adapter at a discharge end of the air pump; and the discharge end of the air pump is in fluid communication with the gas inlet of the nozzle assembly. 17. The applicator of claim 1, further comprising a power source, wherein said power source is contained within the applicator. 18. The applicator of claim 1, further comprising a power source, wherein said power source is outside of the applicator. 19. The applicator of claim 1, wherein the distal end of the second internal chamber has a first opening which has a diameter between about 0.1 inches and about 1 inch; and the distal end of the fourth internal chamber has a second opening which has a diameter between about 0.1 inches and about 1 inch. 20. A method of using an applicator to apply a composition to a surface, wherein the applicator is an applicator of claim 1, wherein the housing further comprises a first liquid in the first internal chamber, a second liquid in the third internal chamber, a viscous liquid in the second internal chamber, and a solid in the fourth internal chamber;comprising the steps of:advancing the first plunger towards the second end of the first barrel, thereby advancing the first floating plunger towards the second end of the first barrel and over the first fluid bypass, and placing the first internal chamber in fluid communication with the second internal chamber;advancing the second plunger towards the second end of the second barrel, thereby advancing the second floating plunger towards the second end of the second barrel and over the second fluid bypass, and placing the third internal chamber in fluid communication with the fourth internal chamber;substantially advancing the housing toward the nozzle assembly, thereby piercing the first piercable barrier with the first piercer and the second piercable barrier with the second piercer, placing the second internal chamber in fluid communication with the nozzle, placing the fourth internal chamber in fluid communication with the nozzle, and forming a pre-composition mixture in the nozzle; andapplying the pre-composition mixture to the surface, wherein the mixture gels to form the composition on the surface.