Clay-based hemostatic agents and devices for the delivery thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/14
A61L-015/16
A61L-015/18
A61K-009/14
A61F-013/00
출원번호
US-0363270
(2012-01-31)
등록번호
US-8343537
(2013-01-01)
발명자
/ 주소
Huey, Raymond J.
Lo, Denny
Burns, Daniel J.
Basadonna, Giacomo
Hursey, Francis X.
출원인 / 주소
Z-Medica, LLC
대리인 / 주소
Knobbe Martens Olson & Bear, LLP
인용정보
피인용 횟수 :
8인용 특허 :
79
초록▼
A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a
A hemostatic device for promoting the dotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
대표청구항▼
1. A hemostatic device comprising: a gauze substrate comprising strands;a clay material disposed on at least two sides of said gauze substrate; anda glycerol binder configured to bind said clay material to said gauze substrate;wherein the gauze strands initially exist separately from the clay materi
1. A hemostatic device comprising: a gauze substrate comprising strands;a clay material disposed on at least two sides of said gauze substrate; anda glycerol binder configured to bind said clay material to said gauze substrate;wherein the gauze strands initially exist separately from the clay material before the gauze strands and the clay material are combined;wherein the hemostatic device is subjected to a drying process after the clay material is bound to the gauze substrate;wherein the glycerol binder has an effect of substantially suppressing clay dust; andwherein the device is configured such that when treating bleeding, application of said device is capable of causing blood to be absorbed into said gauze and causing at least a portion of said clay material to come into contact with blood to assist in accelerating clotting. 2. The device of claim 1, wherein said glycerol binder is glycerin. 3. The device of claim 1, wherein said clay material comprises kaolin or kaolinite. 4. The device of claim 1, wherein said clay material is selected from the group consisting of attapulgite, bentonite, kaolin, kaolinite, and combinations of the foregoing materials. 5. The device of claim 1, further comprising a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 6. The device of claim 1, wherein said gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing. 7. The device of claim 1, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 8. The device of claim 1, further comprising a release agent disposed on said hemostatic device. 9. The device of claim 8, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch. 10. The device of claim 3, wherein the kaolin or kaolinite comprises particles having diameters of less than 0.2 mm. 11. The hemostatic device of claim 1, wherein the glycerol binder is applied to the gauze by a spraying process. 12. The hemostatic device of claim 1, wherein the glycerol binder and the clay material are applied to the gauze by a spraying process. 13. The hemostatic device of claim 1, wherein the glycerol binder is applied to the gauze by immersing the gauze in a liquid comprising the glycerol binder. 14. The hemostatic device of claim 1, wherein the glycerol binder and the clay material are applied to the gauze by immersing the gauze in a liquid comprising the glycerol binder and the clay material. 15. A hemostatic device comprising: a gauze substrate comprising strands;a clay material disposed on said gauze substrate; anda glycerol binder disposed on said gauze substrate to bind said clay material to said gauze substrate;wherein the gauze strands initially exist separately from the clay material;wherein the glycerol binder has an effect of substantially suppressing clay dust and the quantity of glycerol binder in the device exceeds that of any water contained in the device; andthe device is configured such that when treating bleeding, application of said device is capable of causing at least a portion of said clay material to come into contact with blood to assist in accelerating clotting. 16. The device of claim 15, wherein said water-soluble binder is selected from the group consisting of glycerol, glycerol-based compounds, sorbitol, xylitol, maltol, polymeric polyols, and combinations of the foregoing. 17. The device of claim 15, wherein the water-soluble binder is glycerol. 18. The device of claim 15, further comprising a pharmaceutically-active composition selected from the group consisting of antibiotics, antifungal agents, antimicrobial agents, anti-inflammatory agents, analgesics, antihistamines, compounds containing silver or copper ions, and combinations of the foregoing compositions. 19. The device of claim 15, wherein said gauze substrate is fabricated from a material selected from the group consisting of cotton, silk, wool, plastic, cellulose, rayon, polyester, and combinations of the foregoing. 20. The device of claim 15, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 21. The device of claim 15, further comprising a release agent disposed on said hemostatic device. 22. The device of claim 21, wherein said release agent is selected from the group consisting of polyvinyl alcohol, glycerol, silicone, carboxymethyl cellulose, and gelatinized starch. 23. The device of claim 15, wherein the clay material comprises kaolin or kaolinite particles having diameters of less than 0.2 mm. 24. The device of claim 23, wherein said gauze substrate is flexible to allow said gauze substrate to form to a shape of said bleeding wound and to retain a shape of said bleeding wound. 25. A hemostatic device comprising: a gauze substrate;a hemostatic material comprising kaolin or kaolinite; anda glycerol binder applied to said gauze substrate to bind said hemostatic material to said gauze substrate, wherein the glycerol binder and hemostatic material are applied by spraying or immersion;wherein the gauze substrate initially exists separately from the hemostatic material;wherein the glycerol binder has an effect of substantially suppressing clay dust and wherein the quantity of glycerol binder in the device exceeds that of any water contained in the device; andwherein the device is configured such that when treating bleeding, application of said device is capable of causing blood to be absorbed within said device and of causing at least a portion of said hemostatic material to come into contact with blood to assist in accelerating clotting.
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이 특허에 인용된 특허 (79)
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Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
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