초록 ▼

The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated

The invention provides a series of compositions, methods, kits, articles and species associated primarily with the diagnosis and/or treatment of cell proliferation, specifically cancer. Cell proliferation associated with aberrant expression of MUC1 is particularly focused upon. Mechanisms associated with MUC1 cell proliferation are discussed.

대표청구항 ▼

1. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds to a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10. 2. An antibody or antigen-binding fragment thereof as recite

1. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds to a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10. 2. An antibody or antigen-binding fragment thereof as recited in claim 1, wherein the antibody or antigen-binding fragment thereof is bivalent. 3. An antibody or antigen-binding fragment thereof as recited in claim 1, wherein the antibody or antigen-binding fragment thereof is monovalent. 4. A composition comprising the antibody or antigen-binding fragment of claim 1. 5. The composition as recited in claim 4, which is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier. 6. A kit comprising: the antibody or antigen-binding fragment thereof according to claim 1. 7. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10. 8. A monoclonal antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof specifically binds to a peptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10. 9. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10. 10. A polyclonal antibody that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10, but does not binds to an epitope of the MUC1 polypeptide outside of said region. 11. A polyclonal antibody that specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the MUC1 polypeptide consisting of the amino acid sequence set forth at positions 1110-1142 of SEQ ID NO: 10, but does not binds to an epitope of the MUC1 polypeptide outside of said region. 12. A polyclonal antibody produced by immunizing an animal with an immunogen comprising a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10. 13. A polyclonal antibody produced by immunizing an animal with an immunogen comprising a peptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10, wherein said antibody specifically binds to an epitope of a MUC1 polypeptide comprising SEQ ID NO: 10, wherein said epitope is contained within the region of the polypeptide consisting of the amino acid sequence set forth at positions 1110-1154 of SEQ ID NO: 10.