IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0731197
(2010-03-25)
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| 등록번호 |
US-8346356
(2013-01-01)
|
|
발명자
/ 주소 |
- Girouard, Steven D.
- Ross, Jeffrey
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| 출원인 / 주소 |
|
| 대리인 / 주소 |
Schwegman Lundberg & Woessner, P.A.
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| 인용정보 |
피인용 횟수 :
0 인용 특허 :
68 |
초록
▼
An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delive
An implantable system which includes a gene/protein delivery device and a pulse generator, as well as method of preparing the gene/protein delivery device and using the system, are provided. In one embodiment, the implantable system detects a predetermined condition or event and, in response, delivers gene(s) and/or protein(s) in conjunction with delivering pacing and/or defibrillation pulses.
대표청구항
▼
1. A method to prepare an implantable device for gene or protein delivery which includes the delivery of isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising: introducing to a physiologically compatible polymer
1. A method to prepare an implantable device for gene or protein delivery which includes the delivery of isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising: introducing to a physiologically compatible polymer matrix the isolated nucleic acid or isolated protein, or combining physiologically compatible monomers suitable to form a polymeric matrix and the isolated nucleic acid or isolated protein, so as to yield a nucleic acid or protein containing matrix, wherein the isolated nucleic acid or protein is selected so as to prevent, inhibit or treat a cardiac condition in a mammal, and wherein the rate of release of the nucleic acid or protein from the nucleic acid or protein containing matrix is capable of being controlled by an electric signal; andelectrically wiring the nucleic acid or protein containing matrix to an implantable device having a sensor to sense a physiological signal indicative of a predetermined cardiac condition;an event detector, coupled to the sensor, to detect the predetermined cardiac condition from the physiological signal; an implant telemetry module to receive an external command; and an implant controller including a gene or protein delivery control module configured to produce an electrical signal to control iontophoretic gene or protein delivery in response to the external command. 2. The method of claim 1, wherein the nucleic acid or protein is selected to prevent, inhibit or treat atrial fibrillation, heart failure, ventricular fibrillation, ischemia, brachycardia or hyperplasia. 3. The method of claim 1, wherein the nucleic acid is present on one or more vectors. 4. The method of claim 1, wherein the one or more vectors are DNA vectors. 5. The method of claim 1, wherein the one or more vectors are viral vectors. 6. The method of claim 1, wherein the one or more vectors are plasmid vectors. 7. The method of claim 1, wherein the nucleic acid includes morpholino modified nucleotides. 8. The method of claim 1, wherein at least one gene product or protein is a connexin. 9. The method of claim 1, wherein at least one gene product or protein is an atrial-specific ion channel protein. 10. The method of claim 9, wherein the gene product or protein is associated with If. 11. The method of claim 1, wherein at least one gene product or protein is a non-specific ion channel protein. 12. The method of claim 11, wherein the gene product or protein is associated with IKl, ICaL, Ito, IKr, KKur, IKATP, INa or INa/Ca. 13. The method of claim 1, wherein at least one gene product or protein regulates gap junctions. 14. The method of claim 1, wherein at least one gene product or protein alters conduction in the myocardium. 15. The method of claim 1, wherein the protein is or the nucleic acid encodes a regulatory protein that blocks ion channels, upregulates ion channels, downregulates ion channels, or alters ion channel kinetics. 16. The method of claim 1, further comprising an implantable lead system including one or more leads. 17. The method of claim 1, wherein the implantable device further comprises a pacing circuit coupled to the implant controller, and wherein the implant controller includes a pacing control module adapted to control a delivery of pacing pulses in conjunction with the release of the nucleic acid or protein. 18. The method of claim 1, wherein the implantable gene or protein delivery device comprises an epicardial patch including the polymer matrix. 19. An implantable gene or protein delivery device prepared by the method of claim 1. 20. A method to prepare an implantable device having a gene or protein delivery matrix including isolated nucleic acid which encodes at least one gene product or binds at least one selected mRNA in a mammal or isolated protein, comprising: providing an implantable device having a sensor to sense a physiological signal indicative of a predetermined cardiac condition; an event detector, coupled to the sensor, to detect the predetermined cardiac condition from the physiological signal; an implant telemetry module to receive an external command; and an implant controller including a gene or protein delivery control module configured to produce an electrical signal to control iontophoretic gene or protein delivery in response to the external command;providing a matrix comprising a physiologically compatible polymer and the isolated nucleic acid or isolated protein, wherein the rate of release of the nucleic acid or protein from the matrix is capable of being controlled by the electric signal; andelectrically wiring the implantable device to the matrix.
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