Microfluidic device with microstructure, and sensing system and method using same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/62
G01N-033/53
출원번호
US-0359080
(2009-01-23)
등록번호
US-8349275
(2013-01-08)
발명자
/ 주소
Wang, Shau-Chun
Chau, Lai-Kwan
Hsieh, Wen-Hsin
Lee, Chia-Yu
출원인 / 주소
National Chung Cheng University
대리인 / 주소
WPAT, P.C.
인용정보
피인용 횟수 :
2인용 특허 :
3
초록▼
A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a gene
A microfluidic device with microstructure includes a channel for accommodating an electrolytic solution therein and at least one microstructure formed in the channel. When an alternating-current signal is input to the microfluidic device so that a surface of the microstructure is polarized by a generated electric field, ions having polarity reverse to that of an electrolytic solution will migrate to the surface of the microstructure to form a field-induced electrical double layer to result in electro-osmotic flows at the corners at two sides of the microstructure, which causes formation of relatively fierce circular vortices in the solution. A sensing system and a sensing method using the microfluidic device with microstructure are also disclosed.
대표청구항▼
1. A microfluidic device with microstructure, comprising: a base having a channel for accommodating a solution therein, the channel including a sensing section, and the sensing section having at least one microstructure, which is consisting of a plastic material without surface electric charge, arra
1. A microfluidic device with microstructure, comprising: a base having a channel for accommodating a solution therein, the channel including a sensing section, and the sensing section having at least one microstructure, which is consisting of a plastic material without surface electric charge, arranged therein, wherein a plurality of ions migrate to a surface of the at least one microstructure to form a field-induced electrical double layer when the surface of the microstructure has been polarized by an electric field, wherein the base comprises an upper substrate and a lower substrate, one of the upper substrate and the lower substrate being formed with a band-like groove, such that the band-like groove forms the channel when the upper substrate and the lower substrate are assembled together, wherein the upper and the lower substrate are made of the plastic material;a sensing element being arranged in the sensing section, the sensing element being provided on an outer surface thereof with a noble metal nanoparticle layer; andtwo electrodes being electrically and respectively connected to two ends of the sensing section and receiving a high-frequency alternating-current (AC) signal to make a plurality of induced charges not neutralized and the field-induced electrical double layer maintained. 2. The microfluidic device with microstructure as claimed in claim 1, wherein the sensing element is selected from the group consisting of an optical fiber element and a planar waveguide component. 3. The microfluidic device with microstructure as claimed in claim 2, wherein the optical fiber element is a section of an optical fiber with a portion of a surface protective layer and a portion of a cladding layer thereof being stripped therefrom. 4. The microfluidic device with microstructure as claimed in claim 1, wherein the microstructure is an embossed structure having a length or width between 0.1 mm and 1.0 mm. 5. The microfluidic device with microstructure as claimed in claim 4, wherein the embossed structure is selected from the group consisting of a relief-like structure and a wedge-shape microstructure. 6. The microfluidic device with microstructure as claimed in claim 1, wherein the microstructure is formed by a manner selected from the group consisting of ultraviolet-lithography galvanoformung abformung (UV-LIGA), printing, and ablating, with or without combining injection molding. 7. The microfluidic device with microstructure as claimed in claim 1, wherein the microstructure has a height between 10 μm and 1000 μm. 8. The microfluidic device with microstructure as claimed in claim 1, wherein the noble metal nanoparticle layer contains a type of noble metal nanoparticles selected from the group consisting of gold nanoparticles, silver nanoparticles, and other functionalized noble metal particles. 9. The microfluidic device with microstructure as claimed in claim 1, wherein the two electrodes receive a high-frequency alternating-current (AC) signal, which leads the formation of circular vortices in the solution at corners of the microstructure. 10. A sensing system, comprising: a microfluidic device with microstructure, comprising: a base having a channel for accommodating a solution therein, the channel including a sensing section, and the sensing section having at least one microstructure, which is consisting of a plastic material without surface electric charge, arranged therein, wherein a plurality of ions migrate to a surface of the at least one microstructure to form a field-induced electrical double layer when the surface of the microstructure has been polarized by an electric field, wherein the base comprises an upper substrate and a lower substrate, one of the upper substrate and the lower substrate being formed with a band-like groove, such that the band-like groove forms the channel when the upper substrate and the lower substrate are assembled together, wherein the upper and the lower substrate are made of the plastic material;a sensing element being arranged in the sensing section, the sensing element being provided on an outer surface thereof with a noble metal nanoparticle layer; andtwo electrodes being electrically and respectively connected to two ends of the sensing section and receiving a high-frequency alternating-current (AC) signal to make a plurality of induced charges not neutralized and the field-induced electrical double layer maintained;a signal generator being adapted to generate an AC signal to the two electrodes;a light emitting device being adapted to provide an incident light for coupling into the sensing element;a solution supplying device being adapted to supply an analyte-containing solution into the channel; anda light detecting device being adapted to detect an emergent light from the sensing element. 11. The sensing system as claimed in claim 10, wherein the sensing element is selected from the group consisting of an optical fiber element and a planar waveguide component. 12. The sensing system as claimed in claim 11, wherein the optical fiber element is a section of an optical fiber with a portion of a surface protective layer and a portion of a cladding layer thereof being stripped therefrom. 13. The sensing system as claimed in claim 10, wherein the microstructure is an embossed structure having a length or width between 0.1 mm and 1.0 mm. 14. The sensing system as claimed in claim 13, wherein the embossed structure is selected from the group consisting of a relief-like structure and a wedge-shape microstructure. 15. The sensing system as claimed in claim 10, wherein the microstructure is formed by a manner selected from the group consisting of ultraviolet-lithography galvanoformung abformung (UV-LIGA), printing, and ablating, with or without combining injection molding. 16. The sensing system as claimed in claim 10, wherein the microstructure has a height between 10 μm and 1000 μm. 17. The sensing system as claimed in claim 10, wherein the noble metal nanoparticle layer contains a type of noble metal nanoparticles selected from the group consisting of gold nanoparticles, silver nanoparticles, and other functionalized noble metal particles. 18. The sensing system as claimed in claim 10, the two electrodes receive a high-frequency alternating-current (AC) signal, which leads the formation of circular vortices in the solution at corners of the microstructure. 19. The sensing system as claimed in claim 10, wherein the light detecting device is adapted to measure from the emergent light changes in a signal of localized plasmon resonance on the sensing element, and the signal can be generated by any evanescent wave-based sensing means. 20. A sensing method applicable to a microfluidic device, the microfluidic device including a base having a channel, the channel having a sensing section, a sensing element arranged in the sensing section, and two electrodes electrically and respectively connected to two ends of the sensing section; the sensing method comprising the following steps: forming at least one microstructure, which is consisting of a plastic material without surface electric charge, in the sensing section, wherein a plurality of ions migrate to a surface of the at least one microstructure to form a field-induced electrical double layer when the surface of the microstructure has been polarized by an electric field, wherein the base comprises an upper substrate and a lower substrate, one of the upper substrate and the lower substrate being formed with a band-like groove, such that the band-like groove forms the channel when the upper substrate and the lower substrate are assembled together, wherein the upper and the lower substrate are made of the plastic material;preparing a noble metal nanoparticle layer and coating the noble metal nanoparticle on an outer surface of the sensing element;supplying an analyte-containing solution into the channel;providing an incident light and coupling the incident light into the sensing element;inputting a high-frequency alternating-current (AC) signal via the two electrodes to make a plurality of induced charges not neutralized and the field-induced electrical double layer maintained; anddetecting an emergent light from the sensing element. 21. The sensing method as claimed in claim 20, wherein the sensing element is selected from the group consisting of a optical fiber element and a planar waveguide component. 22. The sensing method as claimed in claim 21, wherein the optical fiber element is a section of an optical fiber with a portion of a surface protective layer and a portion of a cladding layer thereof being stripped therefrom. 23. The sensing method as claimed in claim 20, wherein the microstructure is an embossed structure having a length or width between 0.1 mm and 1.0 mm. 24. The sensing method as claimed in claim 23, wherein the embossed structure is selected from the group consisting of a relief-like structure and a wedge-shape microstructure. 25. The sensing method as claimed in claim 20, wherein the microstructure is formed by a manner selected from the group consisting of ultraviolet-lithography galvanoformung abformung (UV-LIGA), printing, and ablating. 26. The sensing method as claimed in claim 20, wherein the microstructure has a height between 10 μm and 1000 μm. 27. The sensing method as claimed in claim 20, wherein the noble metal nanoparticle layer contains a type of noble metal nanoparticles selected from the group consisting of gold nanoparticles, silver nanoparticles, and other functionalized noble metal particles. 28. The sensing method as claimed in claim 20, wherein the high-frequency alternating-current (AC) signal leads the formation of circular vortices in the solution at corners of the microstructure. 29. The sensing method as claimed in claim 20, wherein, in the step of detecting the emergent light, changes in a signal of localized plasmon resonance (LPR) on the sensing element is measured, and the signal can be generated by any evanescent wave-based sensing means.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (3)
Paul Phillip H. ; Rakestraw David J., Electrokinetic micro-fluid mixer.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.