An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotid
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.
대표청구항▼
1. A method of controlling perfusion of at least one organ with medical fluid, the method comprising: inputting organ data, the organ data including at least a type of organ and organ mass;selecting one or more types of perfusion modes;selecting a type of flow control for each selected perfusion mod
1. A method of controlling perfusion of at least one organ with medical fluid, the method comprising: inputting organ data, the organ data including at least a type of organ and organ mass;selecting one or more types of perfusion modes;selecting a type of flow control for each selected perfusion mode;controlling flow of the medical fluid based on the selected perfusion mode and flow control;detecting operating conditions experienced by the medical fluid and organ during perfusion;comparing detected operating conditions with prestored operating conditions and generating a signal indicative of organ viability based on the comparison; andgenerating a message relating to organ viability and/or making automatic adjustments to regulate viability based on the signal generated by the comparison. 2. The method of claim 1, wherein selecting a type of flow control includes selecting between aerobic and anaerobic perfusion for each selected perfusion mode. 3. The method of claim 1, wherein selecting one or more types of perfusion modes includes selecting at least one of hypothermic perfusion, normothermic perfusion, and sequential normothermic and hypothermic perfusion. 4. The method of claim 1, wherein selecting one or more types of perfusion modes includes selecting a plurality of medical fluids at different temperatures. 5. The method of claim 1, wherein selecting one or more types of perfusion modes includes selecting at least one of intermittent perfusion, single pass perfusion, and recirculation perfusion. 6. The method of claim 1, wherein selecting a type of flow control includes selecting flow control based on at least one of perfusate flow rate, perfusate pH, organ inlet pressure and timed sequences. 7. The method of claim 1, wherein detecting operating conditions includes detecting pressure, pH, and oxygen levels. 8. The method of claim 1, further comprising controlling temperature of at least one of the perfusate and the organ with a thermal controller. 9. The method of claim 8, wherein controlling the temperature includes regulating temperature of at least one of the organ container and a perfusate reservoir. 10. The method of claim 8, further comprising sensing a temperature of at least one of an organ, an organ container, and a perfusate reservoir and outputting temperature readings to the thermal controller. 11. The method of claim 1, further comprising setting default settings based on organ type for use in the steps of selecting perfusion mode and flow control. 12. The method of claim 1, including controlling perfusion to a plurality of organs.
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이 특허에 인용된 특허 (99)
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