The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a polymeric polyol core, which may be treated with a nitroaryl compound to form a nitro este
The disclosure relates to biocompatible components useful for forming compositions for use as medical/surgical synthetic adhesives and sealants. Biocompatible components of the present disclosure may include a polymeric polyol core, which may be treated with a nitroaryl compound to form a nitro ester. The resulting nitro ester groups may be reduced to form amino groups which, in turn, may be treated to form isocyanate groups. The resulting isocyanate may then be reacted with a second component to form adhesive and/or sealant compositions.
대표청구항▼
1. A biocompatible component of the formula: wherein R is selected from the group consisting of alkyl groups, cycloalkyl groups, alkenyl groups, alkynyl groups, alkylene groups, cycloalkylene groups, alkenylene groups, alkynylene groups, aromatic groups, heteroaromatic groups, heterocyclic groups, a
1. A biocompatible component of the formula: wherein R is selected from the group consisting of alkyl groups, cycloalkyl groups, alkenyl groups, alkynyl groups, alkylene groups, cycloalkylene groups, alkenylene groups, alkynylene groups, aromatic groups, heteroaromatic groups, heterocyclic groups, and combinations thereof;n can be from 1 to 5;R1 can be the same or different at each location and is selected from the group consisting of OCH2, SCH2, O-alkyl, S-alkyl, O-aryl, and combinations thereof; andPAO is a polyalkylene oxide having a molecular weight of from about 200 to about 4000. 2. The biocompatible component of claim 1, wherein R is selected from the group consisting of methylene, ethylene, propylene, butylene, cyclohexylene, phenylene, pyridylene, and combinations thereof. 3. The biocompatible component of claim 1, wherein the polyalkylene oxide is selected from the group consisting of polyethylene glycols, polypropylene glycols, polyethylene oxides, polypropylene oxides, polyethylene glycols with lactide linkages, polypropylene glycol-co-polyethylene oxide copolymers, polyethylene oxide/polypropylene oxide copolymers, and combinations thereof. 4. A composition comprising the biocompatible component of claim 1 in combination with a second component. 5. The composition of claim 4, wherein the second component comprises a polyol. 6. The composition of claim 5, wherein the polyol is selected from the group consisting of glycerol, trimethylol propane, hexane-1,2,6-triol, polycaprolactone triol, polyalkylene oxides, and combinations thereof. 7. The composition of claim 4, wherein the biocompatible component of claim 1 is present in an amount from about 50 to about 90 percent by weight of the composition, and the second component is present in an amount from about 10 to about 50 percent by weight of the composition. 8. A method for closing a wound comprising: applying the composition of claim 4 to said wound; andallowing the composition to set thereby closing said wound. 9. A method for sealing a leak in animal tissue comprising: applying the composition of claim 4 to said leak; andallowing the composition to set thereby sealing said leak. 10. A method for adhering a medical device to a surface of animal tissue comprising: applying the composition of claim 4 to said device, said surface or both;bringing the device, composition and surface into contact with each other; andallowing the composition to set thereby adhering the device and surface to each other.
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이 특허에 인용된 특허 (15)
Redl Heinz (Vienna ATX) Kriwetz Gert (Graz ATX), Apparatus for applying a tissue adhesive on the basis of human or animal proteins.
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Shelton, IV, Frederick E.; Morgan, Jerome R.; Yates, David C.; Baxter, III, Chester O.; Beckman, Andrew T., Charging system that enables emergency resolutions for charging a battery.
Leimbach, Richard L.; Shelton, IV, Frederick E.; Morgan, Jerome R.; Schellin, Emily A., End effector detection and firing rate modulation systems for surgical instruments.
Shelton, IV, Frederick E.; Schmid, Katherine J.; Scheib, Charles J.; Aronhalt, Taylor W.; Swayze, Jeffrey S.; Contiliano, Joseph H.; Yang, Chunlin; Henderson, Cortney E.; Aldridge, Jeffrey L., End effector including an implantable arrangement.
Shelton, IV, Frederick E.; Overmyer, Mark D.; Yates, David C.; Harris, Jason L., Mechanisms for compensating for drivetrain failure in powered surgical instruments.
Swayze, Jeffrey S.; Hueil, Joseph C.; Morgan, Jerome R.; Shelton, IV, Frederick E., Stapling assembly configured to produce different formed staple heights.
Beckman, Andrew T.; Nalagatla, Anil K.; Hibner, John A.; Shelton, IV, Frederick E., Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band.
Beckman, Andrew T.; Nalagatla, Anil K.; Koch, Jr., Robert L.; Hibner, John A.; Shelton, IV, Frederick E., Surgical apparatus configured to track an end-of-life parameter.
Shelton, IV, Frederick E.; Swayze, Jeffrey S.; Baxter, III, Chester O., Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system.
Parihar, Shailendra K.; Kimsey, John S.; Koch, Jr., Robert L.; Nalagatla, Anil K.; Nguyen, Anthony T., Surgical instrument comprising a gap setting system.
Overmyer, Mark D.; Auld, Michael D.; Adams, Shane R.; Shelton, IV, Frederick E.; Harris, Jason L., Surgical instrument comprising a lockable battery housing.
Kerr, Wendy A.; Lytle, IV, Thomas W.; Overmyer, Mark D.; Swensgard, Brett E.; Sackett, Kevin D.; Leimbach, Richard L.; Houser, Kevin L.; Morgan, Jerome R.; Shelton, IV, Frederick E., Surgical instrument system comprising lockable systems.
Shelton, IV, Frederick E.; Baxter, III, Chester O., Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge.
Hunter, Morgan R.; Schultz, Darwin L.; Worthington, Sarah A.; Shelton, IV, Frederick E.; Weaner, Lauren S.; Vendely, Michael J., Surgical instrument with articulating and axially translatable end effector.
Hunter, Morgan R.; Schultz, Darwin L.; Dunki-Jacobs, Adam R.; Baxter, III, Chester O.; Swayze, Jeffrey S., Surgical instruments with tensioning arrangements for cable driven articulation systems.
Overmyer, Mark D.; Yates, David C.; Shelton, IV, Frederick E.; Adams, Shane R.; Leimbach, Richard L., Surgical stapler having motor control based on an electrical parameter related to a motor current.
Shelton, IV, Frederick E.; Setser, Michael E.; Weisenburgh, II, William B., Surgical stapling instrument with lockout features to prevent advancement of a firing assembly unless an unfired surgical staple cartridge is operably mounted in an end effector portion of the instrument.
Shelton, IV, Frederick E.; Harris, Jason L.; Swensgard, Brett E.; Leimbach, Richard L.; Adams, Shane R.; Overmyer, Mark D., Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures.
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