Applicator for applying functional substances into human skin
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
출원번호
US-0666581
(2003-09-18)
등록번호
US-8353861
(2013-01-15)
발명자
/ 주소
Tobinaga, Yoshikazu
Sugiyama, Susumu
출원인 / 주소
TEXMAC, Inc.
인용정보
피인용 횟수 :
3인용 특허 :
20
초록▼
An applicator for applying functional substances, such as cosmetic powder, food color marking, India ink effect marks, or drugs into human skin, having a base, a plurality of microneedles fixed to and projecting from the base a distance only sufficient to penetrate into the stratum corneum or dermis
An applicator for applying functional substances, such as cosmetic powder, food color marking, India ink effect marks, or drugs into human skin, having a base, a plurality of microneedles fixed to and projecting from the base a distance only sufficient to penetrate into the stratum corneum or dermis, with the microneedles being of a material that is capable of disintegration and dispersion into the stratum corneum or dermis, such as maltose. The needles contain the functional substance for delivery into the stratum corneum or dermis. The microneedles are of a length approximately 0.5 to 500 μm when used to apply a functional substance to the stratum corneum, or are of a length of approximately 500 to 5,000 μm when used to apply a functional substance to the dermis.
대표청구항▼
1. An applicator for applying functional substances into human skin, comprising: (a) a base,(b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is substantially sugars that disso
1. An applicator for applying functional substances into human skin, comprising: (a) a base,(b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is substantially sugars that dissolve within the human body and capable of disintegration and dispersion into the skin, and(c) a functional substance carried by said microneedles for delivery by said microneedles into the skin. 2. An applicator according to claim 1 and characterized further in that said functional substance is distributed in the material of said microneedles. 3. An applicator according to claim 2 and characterized further in that said functional substance is distributed homogeneously throughout said microneedles. 4. An applicator according to claim 1 and characterized further in that said functional substance is encapsulated in said microneedles. 5. An applicator according to claim 1 and characterized further in that said base and said microneedles are integrally molded from the same material. 6. An applicator according to claim 5 and characterized further in that said functional substance is distributed homogeneously throughout said base and microneedles. 7. An applicator according to claim 1 and characterized further in that said microneedles are generally cone shaped. 8. An applicator according to claim 1 and characterized further in that said microneedles are square in cross-section. 9. An applicator according to claim 1 and characterized further in that said microneedles are polygonal in cross-section. 10. An applicator according to claim 1 and characterized further in that said microneedles are at least partially elliptical in cross-section. 11. An applicator according to claim 1 and characterized further in that said microneedles are constricted intermediate their ends to facilitate breaking off the portions of the needles beyond the narrow portions to leave those portions in the skin. 12. An applicator according to claim 1 and characterized further in that said microneedles have relatively thin outer portions and relatively thick inner portions adjacent said base with a step between said portions to facilitate separation of said outer portions from said inner portions with the outer portions remaining in the skin. 13. An applicator according to claim 1 and characterized further in that said microneedles have tips that are knife-shaped to facilitate insertion into the skin. 14. An applicator according to claim 1 and characterized further by microcontainers containing said functional substance, said microcontainers being contained within said microneedles for delivery into the skin. 15. An applicator according to claim 14 and characterized further in that said microneedles are formed with barbed tips and said microcontainers are disposed in said barbed tips for separation with the barbed tips from the remainder of the microneedles for retention in the skin upon removal of the base. 16. An applicator according to claim 1 and characterized further in that said microneedles have capillary recesses in outer portions thereof for retaining said functional substances for delivery into the skin. 17. An applicator according to claim 16 and characterized further in that said capillary recesses extend along a central axis of said microneedles and are open at the outer ends of said microneedles. 18. An applicator according to claim 1 and characterized further in that said microneedles project from said base a distance sufficient to penetrate the stratum corneum. 19. An applicator according to claim 18 and characterized further in that said microneedles project approximately 0.5to 500μm from said base. 20. An applicator according to claim 19 and characterized further in that said microneedles are generally cone shaped with the diameter at said base being approximately 0.1to 100μm. 21. An applicator according to claim 19 and characterized further in that said microneedles are square in cross-section with the sides being approximately 0.1to 100μm at said base. 22. An applicator according to claim 19 and characterized further in that said microneedles are polygonal in cross-section with the sides being approximately 0.1to 100μm at said base. 23. An applicator according to claim 19 and characterized further in that said microneedles are at least partially elliptical in cross-section with a shortest diameter of 0.1to 100μm at said base. 24. An applicator according to claim 1 and characterized further in that said microneedles project from said base a distance sufficient to penetrate the dermis. 25. An applicator according to claim 24 and characterized further in that said microneedles project approximately 500to 5,000μm from said base. 26. An applicator according to claim 25 and characterized further in that said microneedles are generally cone shaped with the diameter at said base being approximately 0.1to 1,000μm. 27. An applicator according to claim 25 and characterized further in that said microneedles are square in cross-section with the sides being approximately 0.1to 1,000μm at said base. 28. An applicator according to claim 25 and characterized further in that said microneedles are polygonal in cross-section with the sides being approximately 0.1to 1,000μm. 29. An applicator according to claim 24 and characterized further in that said microneedles are at least partially elliptical in cross-section with a shortest diameter of 0.1to 1,000μm at said base. 30. An applicator according to claim 1 and characterized further in that said material is substantially maltose. 31. An applicator according to claim 1 and characterized further in that said microneedles have relatively thick inner portions and relatively thick outer portions with constricted intermediate portions therebetween to facilitate separation of said outer portions from said inner portions with the outer portions remaining in the skin. 32. An applicator for applying functional substances into human skin, comprising: (a) a base,(b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin,(c) a functional substance carried by said microneedles for delivery by said microneedles into the skin, and(d) said microneedles having relatively thick inner portions and relatively thick outer portions with constricted intermediate portions therebetween to facilitate separation of said outer portions from said inner portions with the outer portions remaining in the skin. 33. An applicator for applying functional substances into human skin, comprising: (a) a base,(b) a plurality of microneedles fixed to said base and projecting therefrom a distance sufficient to penetrate into the skin, said microneedles being made of a material that is capable of disintegration and dispersion into the skin, and(c) microcontainers containing said functional substance, said microcontainers being contained within said microneedles for delivery into the skin. 34. An applicator according to claim 33 and characterized further in that said microneedles are formed with barbed tips and said microcontainers are disposed in said barbed tips for separation with the barbed tips from the remainder of the microneedles for retention in the skin upon removal of the base.
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이 특허에 인용된 특허 (20)
Cormier Michel J. N. ; Theeuwes Felix T., Device and method for enchancing transdermal sampling.
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Brodie Ivor (Palo Alto CA) Gurnick Henry R. (Pleasanton CA) Holland Christopher E. (Redwood City CA) Moessner Helmut A. (Saratoga CA), Method for providing polyimide spacers in a field emission panel display.
Yuzhakov, Vadim Vladimirovich; Gartstein, Vladimir; Owens, Grover David, Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup.
Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
Nadaud Jean-Francois (Clamart FRX) Laugier Jean-Pierre (Antony FRX) Le Royer Isabelle (Jouy en Josas FRX) Bernard Dominique (Paris FRX), Stabilized emulsion intended to moisturize the skin, and use thereof.
Schehlmann Volker,DEX ; Westenfelder Horst,DEX, Use of ascorbyl 2'-phosphates for stabilizing vitamin A and/or vitamin A derivatives in cosmetic and pharmaceutical preparations.
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