High modulus polyurethane and polyurethane/urea compositions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08G-018/66
C08G-018/72
출원번호
US-0245491
(2008-10-03)
등록번호
US-8357767
(2013-01-22)
우선권정보
AU-2007905409 (2007-10-03)
발명자
/ 주소
Moore, Timothy Graeme
Gunatillake, Pathiraja Arachchillage
Adhikari, Raju
Houshyar, Shadi
출원인 / 주소
Polynovo Biomaterials Limited
인용정보
피인용 횟수 :
0인용 특허 :
26
초록▼
The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between
The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%. The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopedic implant, a drug delivery coating or in tissue engineering.
대표청구항▼
1. A polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 150% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%, wherein the p
1. A polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 150% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%, wherein the polyurethane or polyurethane/urea composition is derived from diisocyanate, and a polyol having the formula: wherein only one of h or k can be zero or both are integers other than zero, j is zero or an integer other than zero, R4 and R8 are independently selected from the group consisting of hydrogen, hydroxylalkyl, aminoalkyl, and carboxyalkyl, R5, R6 and R7 cannot be hydrogen, but are independently a linear or branched alkyl, alkenyl, aminoalkyl, alkoxy or aryl, R5 and R7 are the same or different and distributed alternately, randomly or as blocks within the polyol structure;wherein the polyurethane or polyurethane/urea composition comprises one or more chain extenders, at least one of which is a linear aliphatic glycol having a molecular weight less than 350, andwherein the polyurethane or polyurethane/urea composition is biocompatible and biodegradable. 2. The polyurethane or polyurethane/urea composition of claim 1 comprising at least two polyurethanes and/or polyurethane/ureas having different glass transition temperatures. 3. The polyurethane or polyurethane/urea composition of claim 1 wherein the composition is derived from at least two diisocyanates at least one of the diisocyanates containing isocyanate moieties in an unsymmetric configuration. 4. The polyurethane or polyurethane/urea composition of claim 3 wherein at least one of the diisocyanates contains isocyanate moieties in a symmetric configuration. 5. The polyurethane or polyurethane/urea composition of claim 1 wherein the composition is derived from at least two diisocyanates at least one of the diisocyanates containing isocyanate moieties attached to a cyclic structure. 6. The polyurethane or polyurethane/urea composition of claim 5 wherein at least one of the diisocyanates contains isocyanate moieties attached to a linear structure. 7. The polyurethane or polyurethane/urea composition of claim 1 additionally comprising one or more chain extenders. 8. The polyurethane or polyurethane/urea composition of claim 7 wherein at least one of the chain extenders has a hydrolysable linking group. 9. An article of manufacture formed from the polyurethane or polyurethane/urea compositions of claim 1. 10. The article of claim 9 wherein the article is a medical device, an orthopedic implant, a bone fixation device, a vascular stent, a spinal cage or a scaffold. 11. The polyurethane or polyurethane/urea composition of claim 1, wherein the linear aliphatic glycol is a C2-C10 linear aliphatic glycol. 12. The polyurethane or polyurethane/urea composition of claim 1, wherein the linear aliphatic glycol is ethylene glycol, diethylene glycol, tetraethylene glycol, 1,3-propane diol, 1,4-butane diol, 1,6-hexanediol, 1,7-heptanediol, 1,8-octanediol, 1,9-nonanediol, or 1,10-decanediol. 13. The polyurethane or polyurethane/urea composition of claim 1, wherein the composition comprises a hard segment representing 40 to 100% by weight of the composition. 14. The polyurethane or polyurethane/urea composition of claim 3, wherein the at least one diisocyanate containing isocyanate moieties in an unsymmetric configuration is selected from the group consisting of isophorone diisocyanate, toluene diisocyanate, lysine diisocyanate ethyl ester and lysine diisocyanate methyl ester. 15. The polyurethane or polyurethane/urea composition of claim 4, wherein the at least one diisocyanate containing isocyanate moieties in a symmetric configuration is selected from the group consisting of 1,6-hexamethylene diisocyanate, trans-cyclohexane diisocyanate, 1,4-butanediisocyanate, 1,2-ethanediisocyanate, 1,3-propanediisocyanate, para-tetramethyl xylene diisocyanate, 4,4′-methylene diphenyldiisocyanate, 1,4-naphthalene diisocyanate, para-phenylene diisocyanate, 4,4′-methylene-bis(cyclohexyl isocyanate), meta-tetramethyl xylenediisocyanate and cis-cyclohexanediisocyanate. 16. The polyurethane or polyurethane/urea composition of claim 1, wherein the composition is extrusion processed. 17. The polyurethane or polyurethane/urea composition of claim 16, wherein the composition is extrusion processed into fibres. 18. The polyurethane or polyurethane/urea composition of claim 17, wherein the fibres are oriented. 19. The article of claim 9 wherein the article is formed from extrusion processed fibres. 20. The polyurethane or polyurethane/urea composition of claim 1 further comprising cells and/or growth factors. 21. The polyurethane or polyurethane/urea composition of claim 20 wherein the cells are progenitor cells. 22. The polyurethane or polyurethane/urea composition of claim 1 further comprising pharmaceuticals for use in drug delivery. 23. The polyurethane or polyurethane/urea composition of claim 8 further comprising pharmaceuticals for use in drug delivery. 24. The polyurethane or polyurethane/urea composition of claim 1 further comprising a substance selected from the group consisting of barium sulphate, barium carbonate, halogen-containing compounds, tricalcium phosphate, hydroxyapatite or gold.
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