IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0745439
(2003-12-22)
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등록번호 |
US-8360976
(2013-01-29)
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발명자
/ 주소 |
|
출원인 / 주소 |
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인용정보 |
피인용 횟수 :
14 인용 특허 :
62 |
초록
▼
A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and se
A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.
대표청구항
▼
1. A system for diagnosing a gastrointestinal condition comprising: an autonomous capsule sized to pass through the intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule; and a sensor configured to sense light of at least one predetermined wa
1. A system for diagnosing a gastrointestinal condition comprising: an autonomous capsule sized to pass through the intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule; and a sensor configured to sense light of at least one predetermined wavelength at a first location within the intestinal tract and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength;a processor coupled to the sensor to receive a signal representative of light of the at least one predetermined wavelength sensed by the sensor, wherein the processor is configured to control the light source to emit light, determine at least one condition of: a presence of a substance, an absence of a substance, and a condition of tissue of the intestinal tract based at least in part on the signal representative of light sensed by the sensor;a capsule tracking system configured to track a location of the capsule within the intestinal tract independent of capsule orientation, via an acoustic signal transmitted between the autonomous capsule and a location external a patient's body, anda battery disposed within the capsule for powering the light source, the sensor, and portions of the capsule tracking system as the capsule is moving through the intestinal tract, the battery configured to allow the capsule to emit and sense light along a substantial length of the intestinal tract while transmitting the acoustical tracking signal so as to develop a map of sensed optical characteristics along a substantial length of the intestinal tract, wherein the capsule tracking system comprises:a plurality of acoustic transducers at the capsule, each of the plurality of acoustic transducers being arranged to emit an acoustic signal detectable externally of a patient's body as the capsule passes through at least a portion of the intestinal tract; andat least one external acoustic receiver configured to sense the acoustic signal transmitted by the capsule,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the capsule may be derived. 2. The system of claim 1, wherein the light source emits light at the at least one predetermined wavelength. 3. The system of claim 1, wherein the capsule further comprises a filter coupled to the sensor, wherein the filter is configured to filter light into the sensor of the at least one predetermined wavelength. 4. The system of claim 1 wherein the capsule tracking system is configured to track location of the capsule within a three-dimensional coordinate system. 5. The system of claim 4 wherein the processor is coupled to the capsule tracking system to receive information on the location of the capsule within the intestinal tract, and wherein the processor is arranged to identify the first location of the at least one condition within the portion of the intestinal tract. 6. The system of claim 1 wherein the capsule tracking system is configured to track location of the capsule along a length of a portion of the intestinal tract. 7. The system of claim 6 wherein the processor is coupled to the capsule tracking system to receive information on the location of the capsule within the intestinal tract, and wherein the processor is arranged to identify a location of a sensed condition along a length of the portion of the intestinal tract. 8. The system of claim 6 further comprising a mapping element configured to map locations of the capsule along the length of the portion of the intestinal tract with respect to conditions sensed by the sensor at corresponding locations along the length of the portion of the intestinal tract. 9. The system of claim 8 further comprising: a display coupled to the processor, the display being configured to display a diagnostic map of sensed condition of the intestinal tract along the length of the portion of the intestinal tract. 10. The system of claim 6 wherein the capsule tracking system is arranged to determine capsule location along the length the portion of the intestinal tract, from a determination of a plurality of locations of the capsule as the capsule passes through the portion of the intestinal tract. 11. The system of claim 1 wherein the capsule tracking system comprises: an acoustic transducer transmitter and an acoustic transducer receiver, wherein the acoustic transmitter is arranged to transmit a tracking signal from the acoustic transmitter to the acoustic receiver, between the autonomous capsule and a location external to a patient's body, andwherein in use, the acoustic transmitter is located at one of the autonomous capsule and the location external the patient's body and the acoustic receiver is located at the other of the autonomous capsule and the location external the patient's body. 12. The system of claim 1 wherein the capsule further comprises: a telemetry device arranged to transmit a telemetry signal corresponding to the light sensed by the sensor, and a telemetry receiver for receiving the telemetry signal. 13. The system of claim 12 wherein the processor is located in an external device coupled to the telemetry receiver. 14. The system of claim 1 wherein the capsule further comprises a marking mechanism configured to mark an identified location of a sensed condition within the intestinal tract. 15. The system of claim 14 wherein the marking mechanism comprises a substance release mechanism. 16. The system of claim 15 wherein the substance release mechanism comprises a dye release mechanism. 17. The system of claim 14 wherein the marking mechanism comprises a position anchoring mechanism. 18. The system of claim 1 wherein the presence of a substance comprises a presence of blood. 19. The system of claim 1 wherein the absence of a substance comprises an absence of blood in tissue. 20. The system of claim 1 wherein the presence of a substance comprises a presence of ischemic tissue. 21. The system of claim 1 wherein the presence of a substance comprises a presence of necrotic tissue. 22. The system of claim 1 wherein the presence of a substance comprises a presence of hemoglobin, and wherein the absence of a substance comprises an absence of hemoglobin. 23. The system of claim 1 wherein the at least one predetermined wavelength is within a range of wavelengths of between about 540 nanometers and about 620 nanometers. 24. The system of claim 1 further comprising a treatment capsule configured to treat the condition determined by the capsule. 25. The system of claim 24 wherein the treatment capsule comprises a treatment capsule tracking system configured to track the location of the capsule and identify the location of the condition determined by the capsule. 26. The system of claim 25 wherein the treatment capsule tracking system is configured to track the location of the treatment along the length of at least a portion of the intestinal tract. 27. A system for treating or diagnosing the intestinal tract of a patient comprising: encapsulation means for moving through a portion of an intestinal tract;means for determining a location of the encapsulation means within a portion of the intestinal tract via an acoustic means transmitted between the capsule means and a location external a patient's body;light emitting means for emitting a light of at least one wavelength;optical sensing means for sensing an optical characteristic of the intestinal tract;tracking means for tracking the encapsulation means at a plurality of locations and for tracking a sensed optical characteristic at the plurality of locations;means for electrical power storage for powering the light emitting means, sensing means and portions of the tracking means as the encapsulation means is moving through the intestinal tract so as to allow the capsule to emit and sense light along a substantial length of the intestinal tract while transmitting the acoustical means so as to develop a map of sensed optical characteristics along a substantial length of the intestinal tract; anda processing means for determining a condition within the portion of the intestinal tract based at least in part on the optical characteristic sensed at the plurality of locations, wherein the tracking means comprises:a plurality of acoustic transducers at the encapsulation means, each of the plurality of acoustic transducers being arranged to emit an acoustic signal detectable externally of a patient's body as the encapsulation means passes through at least a portion of the intestinal tract; andat least one external acoustic receiver configured to sense the acoustic signal transmitted by the encapsulation means,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the encapsulation means may be derived. 28. The system of claim 27 wherein the means for determining location of the encapsulation means comprises means for determining location of the encapsulation means along a length of the portion of the intestinal tract. 29. The system of claim 27 further comprising a mapping means for mapping locations of the encapsulation means along the length of the portion of the intestinal tract with respect to conditions determined by the processor means at corresponding locations of the conditions along the length of the portion of the intestinal tract. 30. The system of claim 27 wherein the condition is selected from a group comprising: a presence of a substance, an absence of a substance, and a tissue condition. 31. The system of claim 27 wherein the condition is presence of blood. 32. The system of claim 27 wherein the condition is absence of blood in tissue. 33. The system of claim 27 wherein the condition is the presence of ischemic tissue. 34. The system of claim 27 wherein the condition is the presence of necrotic tissue. 35. The system of claim 27 wherein the at least one predetermined wavelength is within a range of wavelengths of between about 540 nanometers and about 620 nanometers. 36. A method for diagnosing a condition of a gastrointestinal tract comprising: providing an autonomous capsule comprising a light source and an optical sensor configured to sense light of at least one predetermined wavelength and a battery for powering the light source as the capsule is moving through the intestinal tract;tracking a position of the autonomous capsule within the gastrointestinal tract via an acoustic signal transmitted between the autonomous capsule and a location external a patient's body using a capsule tracking system, wherein the capsule tracking system comprises:a plurality of acoustic transducers at the capsule, each of the plurality of acoustic transducers emitting an acoustic signal detectable externally of a patient's body as the capsule passes through at least a portion of the intestinal tract; andat least one external acoustic receiver sensing the acoustic signal transmitted by the capsule,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the capsule is derived;emitting light from the capsule in an intestinal tract utilizing power from the battery, the battery configured to allow emission of light along a substantial length of the intestinal tract while transmitting the acoustical tracking signal so as to develop a map of sensed optical characteristics along a substantial length of the intestinal tract;sensing light of the at least one predetermined wavelength with the optical sensor at a location within a portion of a gastrointestinal tract so as to determine an optical characteristic of tissue at the location within a portion of the gastrointestinal tract;anddetermining whether at least one condition exists at the location, the condition being selected from: a presence of a substance, an absence of a substance, and a condition of tissue of the intestinal tract, and the condition determined at least in part from the signal representative of light sensed by the sensor. 37. The method of claim 36 further comprising: sensing light at a plurality of locations along a length of a portion of a gastrointestinal tract utilizing power from the battery so as to determine an optical characteristic of intestinal tissue at each location of the plurality of locations;andmapping an optical characteristic of intestinal tract tissue with respect to each of the plurality of locations along the length of the gastrointestinal tract. 38. A system for diagnosing a gastrointestinal condition comprising: an autonomous capsule sized to pass through the intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule; and a sensor configured to sense light of at least one predetermined wavelength at a first location within the intestinal tract and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength;a processor coupled to the sensor to receive a signal representative of light of the at least one predetermined wavelength sensed by the sensor, wherein the processor is configured to determine at least one condition of: a presence of a substance, an absence of a substance, and a condition of tissue of the intestinal tract based at least in part on the signal representative of light sensed by the sensor;a capsule tracking system configured to track a location of the capsule within the intestinal tract via an acoustic signal transmitted between the autonomous capsule and a location external a patient's body;a battery disposed within the capsule for powering the light source, the sensor and portions of the capsule tracking system as the capsule is moving through the intestinal tract; anda voltage conversion device coupled to the battery for converting a battery voltage, wherein the tracking means comprises: a plurality of acoustic transducers at the capsule, each of the plurality of acoustic transducers being arranged to emit an acoustic signal detectable externally of a patient's body as the capsule passes through at least a portion of the intestinal tract; andat least one external acoustic receiver configured to sense the acoustic signal transmitted by the capsule,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the capsule may be derived. 39. The system of claim 38, further comprising a stimulation electrode positioned on a surface of the capsule and coupled to the processor, wherein the voltage conversion device is configured to convert the battery voltage for emitting a tissue stimulation signal from the stimulation electrode. 40. A system for diagnosing a gastrointestinal condition comprising: an autonomous capsule sized to pass through the intestinal tract of a patient, the capsule comprising: a light source configured to emit light from the capsule; and a sensor configured to sense light of at least one predetermined wavelength at a first location within the intestinal tract and to output a signal representative of light sensed by the sensor at the at least one predetermined wavelength;a processor coupled to the sensor to receive a signal representative of light of the at least one predetermined wavelength sensed by the sensor, wherein the processor is configured to control the light source to emit light, determine at least one condition of: a presence of a substance, an absence of a substance, and a condition of tissue of the intestinal tract based at least in part on the signal representative of light sensed by the sensor;a capsule tracking system configured to track a location of the capsule within the intestinal tract via an acoustic signal transmitted between the autonomous capsule and a location external a patient's body, anda battery disposed within the capsule for powering the light source, the sensor, and portions of the capsule tracking system as the capsule is moving through the intestinal tract, the battery coupled directly to the processor, wherein the tracking means comprises:a plurality of acoustic transducers at the capsule, each of the plurality of acoustic transducers being arranged to emit an acoustic signal detectable externally of a patient's body as the capsule passes through at least a portion of the intestinal tract; andat least one external acoustic receiver configured to sense the acoustic signal transmitted by the capsule,wherein the acoustic signal of each of the plurality of acoustic transducers provides information from which the location of the capsule may be derived.
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