IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0037971
(2011-03-01)
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등록번호 |
US-8361082
(2013-01-29)
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발명자
/ 주소 |
- Jones, Michael L.
- Lubock, Paul
- Merritt, John
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출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
26 인용 특허 :
330 |
초록
▼
A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elonga
A marker delivery device includes an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen. At least one elongated fibrous marker body is slidably disposed within the inner lumen of the elongated delivery cannula. The at least one elongated fibrous marker body includes a plurality of bioabsorbable polymeric strands. The strands are compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula. A releasable plug is disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section.
대표청구항
▼
1. A marker delivery device for an intracorporeal tissue site, comprising: a) an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen;b) at least one elongated fibrous marker body slidably di
1. A marker delivery device for an intracorporeal tissue site, comprising: a) an elongated delivery cannula which has a distal end section, an inner lumen and a discharge opening in the distal end section in communication with the inner lumen;b) at least one elongated fibrous marker body slidably disposed within the inner lumen of the elongated delivery cannula, the at least one elongated fibrous marker body comprising a plurality of bioabsorbable polymeric strands, said strands being compressed to a compressed configuration and bound together in the compressed configuration with a polymer binding agent prior to insertion into the elongated delivery cannula; andc) a releasable plug disposed within a distal portion of the inner lumen and distal to the at least one elongated fibrous marker body so as to at least partially occlude the discharge opening in the distal end section. 2. The marker delivery device of claim 1, wherein the releasable plug comprises a material that swells in the presence of fluids. 3. The marker delivery device of claim 1, wherein the releasable plug comprises at least one of polyethylene glycol and oxidized cellulose. 4. The marker delivery device of claim 3, wherein the polyethylene glycol of the releasable plug has a molecular weight of about 5000 to about 20,000 Daltons. 5. The marker delivery device of claim 3, wherein the polyethylene glycol of the releasable plug has a molecular weight of about 8000 to about 10,000 Daltons. 6. The marker delivery device of claim 1, wherein the releasable plug has a non-magnetic marker element which is remotely detectable by magnetic resonance. 7. The marker delivery device of claim 1, wherein the releasable plug comprises fibers of bioabsorbable material. 8. The marker delivery device of claim 7, wherein the fibrous releasable plug has a radiographically detectable element. 9. The marker delivery device of claim 8, wherein the radiographically detectable element surrounds an exterior portion of the fibrous releasable plug. 10. The marker delivery device of claim 9, wherein the bioabsorbable material is selected from the group consisting of polylactic acid, polyglycolic acid, copolymers and blends thereof. 11. The marker delivery device of claim 1, comprising a radiographically detectable element positioned to surround an exterior portion of a respective fibrous marker body of the at least one elongated fibrous marker body. 12. The marker delivery device of claim 1, wherein the at least one elongated fibrous marker body comprises fibers of oxidized cellulose. 13. The marker delivery device of claim 1, wherein the at least one elongated fibrous marker body comprises fibers of oxidized regenerated cellulose. 14. The marker delivery device of claim 1, wherein the at least one elongated fibrous marker body comprises bioabsorbable fibers of polymeric material selected from the group consisting of polylactic acids, polyglycolic acids, copolymers and blends thereof. 15. The marker delivery device of claim 1, comprising a plunger which is slidably disposed within the inner lumen of the elongated delivery cannula and which has a distal end proximal to the at least one elongated fibrous marker body in the inner lumen. 16. A marker delivery device for an intracorporeal tissue site, comprising: a) an elongated delivery cannula which has a distal end section, a discharge opening in the distal end section and an inner lumen extending to and in communication with the discharge opening;b) a releasable plug which has an MRI detectable marker element incorporated therein and which is disposed at least in part within a distal portion of the inner lumen so as to partially occlude the discharge opening in the distal end section;c) a plurality of elongated fibrous marker bodies slidably disposed within the inner lumen of the elongated delivery cannula proximal to the releasable plug, each of the plurality of elongated fibrous marker bodies having a length comprising a plurality of separate bioabsorbable fibers which are compressed and bound together with a synthetic polymer binding agent so as to form the length prior to insertion into the elongated delivery cannula; andd) a plunger slidably disposed within the inner lumen of the elongated delivery cannula with a pusher end proximal to the plurality of elongated fibrous marker bodies in the inner lumen. 17. The marker delivery device of claim 16, wherein the releasable plug expands in the presence of body fluids. 18. The marker delivery device of claim 16, wherein the releasable plug comprises a material selected from the group consisting of oxidized cellulose, oxidized regenerated cellulose, and polyethylene glycol. 19. The marker delivery device of claim 16, wherein each of the plurality of elongated fibrous marker bodies is expandable upon contact with body fluid or other water based fluid. 20. The marker delivery device of claim 16, wherein at least one of the plurality of elongated fibrous marker bodies includes a radiographically detectable element that surrounds an exterior portion of a respective fibrous marker body. 21. The marker delivery device of claim 16, wherein the MRI detectable marker element is about 0.5 to about 5 mm in maximum transverse dimension. 22. The marker delivery device of claim 16, wherein the MRI detectable marker element is about 1 to about 3 mm in maximum transverse dimension. 23. A marker delivery device for an intracorporeal site within a patient, comprising: a. an elongated delivery cannula which has a distal end, a discharge opening in the distal end and an inner lumen extending to and in communication with the discharge opening;b. a releasable plug disposed within the inner lumen which partially occludes the discharge opening;c. at least one short term marker disposed within the inner lumen proximal to the releasable plug; andd. a plurality of elongated fibrous markers which are inserted into and slidably disposed within the inner lumen proximal to the at least one short term marker, each of the elongated fibrous markers having a length comprising a plurality of separate bioabsorbable fibers that are compressed and bound together with a polymer binding agent prior to insertion into the inner lumen of the elongated delivery cannula. 24. The marker delivery device of claim 23, wherein at least one elongated fibrous marker of the plurality of elongated fibrous markers has a radiographic imageable element. 25. The marker delivery device of claim 24, wherein the radiographically detectable element surrounds a portion of one elongated fibrous marker of the plurality of elongated fibrous markers. 26. The marker delivery device of claim 23, wherein the releasable plug has a non-magnetic, MRI detectable marker element incorporated therein. 27. The marker delivery device of claim 26, wherein the non-magnetic, MRI detectable marker element is about 0.5 to about 5 mm in maximum dimension. 28. The marker delivery device of claim 26, wherein the non-magnetic, MRI detectable marker element is about 1 to about 3 mm in maximum dimension. 29. The marker delivery device of claim 23, wherein the binding agent is a polymer binding agent selected from the group consisting of polyvinyl alcohol, polyethylene glycol and polyvinyl pyrollidone. 30. The marker delivery device of claim 23, wherein the releasable plug is comprised of a material which expands in the presence of body fluids.
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