This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/m
This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.
대표청구항▼
1. A controlled release composition, comprising: (I) a water-swellable linear polymer obtained by reacting: (i) a polyethylene glycol; (ii) a polypropylene glycol; (iii) a diol; and (iv) a diisocyanate; and (II) a pharmaceutically active agent; wherein the molar ratio of the components (i), (ii), (i
1. A controlled release composition, comprising: (I) a water-swellable linear polymer obtained by reacting: (i) a polyethylene glycol; (ii) a polypropylene glycol; (iii) a diol; and (iv) a diisocyanate; and (II) a pharmaceutically active agent; wherein the molar ratio of the components (i), (ii), (iii) and (iv) is in the range 0.01-1 to 0.01-1 to 1 to 1.02-3, respectively. 2. The composition of claim 1, wherein the polyethylene glycol is a linear polyethylene glycol having a molecular weight of 400 g/mol to 2000 g/mol. 3. The composition of claim 1, wherein the polypropylene glycol is a linear polypropylene glycol having a molecular weight of 400 g/mol to 2000 g/mol. 4. The composition of claim 1, wherein the diol is a C5 to C20 diol. 5. The composition of claim 1, wherein the diol is a C8 to C15 diol. 6. The composition of claim 1, wherein the diol is 1,6-hexanediol, 1,10-decanediol, 1,12-dodecanediol or 1,16-hexadecanediol. 7. The composition of claim 1, wherein the diisocyanate is dicyclohexylmethane-4,4-diisocyanate, diphenylmethane-4,4-diisocyanate, or 1,6-hexamethylene diisocyanate. 8. The composition of claim 1, wherein the molar amount of component (iv) is equal to the combined molar amounts of components (i), (ii), and (iii). 9. The composition of claim 1, wherein the composition is in a solid dosage form. 10. The composition of claim 9, wherein the solid dosage form is a suppository, a ring or pessary for vaginal use, a buccal insert, or a transdermal patch. 11. The composition of claim 9, wherein the composition is an implant. 12. A controlled release composition, comprising (I) a water-swellable linear polymer obtained by reacting: (i) a polyethylene glycol; (ii) a polypropylene glycol; (iii) a diol; and (iv) dicyclohexylmethane-4,4-diisocyanate; and (II) a pharmaceutically active agent; wherein the molar ratio of components (i), (ii), (iii) and (iv) is 1:1:1:3. 13. The composition of claim 12, wherein the polyethylene glycol has a molecular weight of 900 g/mol. 14. The composition of claim 12, wherein the polyethylene glycol has a molecular weight of 2000 g/mol. 15. The composition of claim 12, wherein the polypropylene glycol has a molecular weight of 1000 g/mol. 16. The composition of claim 12, wherein the polypropylene glycol has a molecular weight of 2000 g/mol. 17. The composition of claim 12, wherein the diol is 1,12-dodecanediol.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (263)
Bartrol Javier (Barcelona ESX) Anguita Manuel (Barcelona ESX) Carceller Elena (Barcelona ESX), 2-picolylamine derivatives.
Wolfgang Kaufhold DE; Hans-Georg Hoppe DE; Herbert Heidingsfeld DE; Rainer Ohlinger DE; Michael Kalbe DE, Aliphatic, low-emission thermoplastic polyurethane molding materials suitable for sintering.
Schutze Detlef-Ingo,DEX ; Thoma Wilhelm,DEX ; Nachtkamp Klaus,DEX ; Pedain Josef,DEX ; Schmitz Reinold,DEX, Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor.
Schutze Detlef-Ingo,DEX ; Thoma Wilhelm,DEX ; Nachtkamp Klaus,DEX ; Pedain Josef,DEX ; Schmitz Reinold,DEX, Aqueous coating compositions and their use for the preparation of coatings that are permeable to water vapor.
Place, Virgil A.; Wilson, Leland F.; Doherty, Jr., Paul C.; Hanamoto, Mark S.; Spivack, Alfred P.; Gesundheit, Neil; Bennett, Sean R., Co-administration of a prostaglandin and an androgenic agent in the treatment of female sexual dysfunction.
Matsumoto Yukio (Yokohama JPX) Kunii Nobuaki (Yokohama JPX), Coating composition a non-porous moisture-permeable coating layer or film of a hydrophilic polyurethane resin.
McGee John D. ; Bammel Brian D. ; Seaver Todd A. ; Ohrbom Walter H. ; Rehfuss John W. ; Menovcik Gregory G. ; Harris Paul J., Coating compositions with low molecular weight carbamate or urea component.
Embrey Mostyn P. (Oxford GB2) Graham Neil B. (Dunbartonshire GB6), Controlled release compositions including polyethylene oxide with urethane cross-linking.
Bammel Brian D. ; McGee John D. ; Ohrbom Walter H. ; Seaver Todd A. ; Menovcik Gregory G. ; Harris Paul J. ; Rehfuss John W., Curable coating composition.
Ohrbom Walter H. ; Bammel Brian D. ; McGee John D. ; Seaver Todd A. ; Menovcik Gregory G. ; Harris Paul J. ; Rehfuss John W., Curable coating composition.
Menovcik Gregory G. ; McGee John D. ; Ohrbom Walter H. ; Bammel Brian D. ; Seaver Todd A. ; Rehfuss John W., Curable coating composition including compound having carbamate and hydroxyl functionality.
Green Marvin L. ; McGee John D. ; Bammel Brian D. ; Regulski Danielle A. ; Ohrbom Walter H., Curable coating compositions containing blends of carbamate-functional compounds.
Ohrbom Walter H ; Menovcik Gregory G. ; St. Aubin Donald L. ; Boisseau John E. ; Rehfuss John W. ; McGee John D. ; Bammel Brian D. ; Regulski Danielle ; Bradford Christopher, Curable coating compositions containing blends of carbamate-functional compounds.
Ohrbom Walter H ; Menovcik Gregory G. ; St. Aubin Donald L. ; Boisseau John E. ; Rehfuss John W. ; McGee John D. ; Bammel Brian D. ; Regulski Danielle ; Bradford Christopher, Curable coating compositions containing blends of carbamate-functional compounds.
Ohrbom Walter H. ; Menovcik Gregory G. ; St. Aubin Donald L. ; Boisseau John E. ; Rehfuss John W., Curable coating compositions containing blends of carbamate-functional compounds.
McGee John D. ; Bammel Brian D. ; Ohrbom Walter H. ; Seaver Todd A. ; Menovcik Gregory G. ; Harris Paul J. ; Rehfuss John W., Curable compositions for coatings.
Fildes Francis J. T. (Macclesfield GB2) Hutchinson Francis G. (Lymm GB2), Delivery means for biologically active agents comprising hydrophilic polyurethane.
Wong Patrick S. L. (Palo Alto CA) Pharriss Bruce B. (Palo Alto CA), Delivery system with mated members for storing and releasing a plurality of beneficial agents.
Merida A. D'Augustine ; James H. Liu ; Donald C. Harrison, Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections.
Alam Rafeul (14910 Wilderness Cliff Houston TX 77062) Grant J. Andrew (2914 Beluche St. Galveston TX 77551), Effects of misoprostol on allergic responses.
Gibson, John W.; Miller, Stacey S.; Middleton, John C.; Tipton, Arthur J., High viscosity liquid controlled delivery system and medical or surgical device.
John W. Gibson ; Stacey A. Sullivan ; John C. Middleton ; Arthur J. Tipton, High viscosity liquid controlled delivery system and medical or surgical device.
Allen Douglas J. (Indianapolis IN) Johnson Kirk W. (Indianapolis IN) Nevin Robert S. (Indianapolis IN), Hydrophilic polyurethane membranes for electrochemical glucose sensors.
Brodman Michael L. (Great Neck NY) Kirschbaum Warren (Kemah TX) Weinberg Steven L. (League City TX), Intravaginal device and method for delivering a medicament.
Flodin Per,SEX, Linear block polymer comprising urea and urethane groups, method for the production of linear block polymers and use of the block polymers as implants.
Koleske Joseph V. (Charleston WV) Smith Oliver W. (South Charleston WV) France Haywood G. (South Charleston WV) Taller Robert A. (Charleston WV), Low-energy-curable coatings compositions.
Kohno Kenji (Nagaokakyo JPX) Nagataki Yoshiyuki (Osaka JPX) Miyata Kazushi (Osaka JPX) Higashi Hiroshi (Osaka JPX), Magnetic recording medium having a magnetic layer formed from an aromatic polycarbonate polyurethane resin.
English James P. (Birmingham AL) McNeely Gerald W. (Spartanburg SC) Dunn Richard L. (Birmingham AL), Method for making a biodegradable adhesive for soft living tissue.
Virgil A. Place ; Leland F. Wilson ; Paul C. Doherty, Jr. ; Mark S. Hanamoto ; Alfred P. Spivack ; Neil Gesundheit ; Sean R. Bennett, Method for minimizing excess collagen deposition.
Ohrbom Walter H. ; Campbell Donald H. ; St. Aubin Donald L., Method for modified aminoplast compounds, aminoplasts obtained thereby and coatings containing the same.
McKee Rex N. (2368 Mill Rd. Traer IA 50675) Wingrove Frank A. (1029 Sunrise Blvd. Waterloo IA 50701), Method of treating damaged mucosal and epithelial tissues with misoprostol.
McKee Rex N. (2368 Mill Rd. Traer IA 50675) Wingrove Frank A. (1029 Sunrise Blvd. Waterloo IA 50701), Method of treating damaged mucosal and epithelial tissues with misoprostol.
Higuchi Takeru (Lawrence KS) Leeper Harold M. (Mountain View CA), Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient.
Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (Atherton CA) Theeuwes Felix (Los Altos CA), Osmotic releasing device having a plurality of release rate patterns.
Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (Atherton CA) Theeuwes Felix (Los Altos CA), Osmotic releasing system for administering ophthalmic drug to eye of animal.
Zaffaroni Alejandro (Atherton CA) Michaels Alan S. (San Francisco CA) Theeuwes Felix (Los Altos CA), Osmotic releasing system with means for changing release therefrom.
Piccirilli Robert M. (Pittsburgh PA) Chang Wen-Hsuan (Gibsonia PA) McKeough David T. (Gibsonia PA) Porter ; Jr. Samuel (Natrona Heights PA), Polyester coating composition.
Menovcik Gregory L. (Farmington Hills MI) Ohrbom Walter H. (Commerce MI), Polyurethane polymer or oligomer having carbamate groups, method for its preparation, and coating composition.
Frlich Jrgen (Rhrichtweg 11 3000 Hannover 71 DEX) Bippi Herbert (Wolfratshauser Str. 35 8032 Pullach DEX), Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compoun.
Frolich Jurgen C.,DEX ; Bippi Herbert,DEX, Prostaglandin E1 derivatives as pharmacologically active agents, especially for transcutaneous administration.
Wagner Julie Ann ; Zukowski Joseph Michael ; Robinson Larry Richard ; Deckner George Endel ; Rinaldi Marie Antoinette ; Szymanski Victoria Claire, Stable topical compositions.
Gould Francis E. (Princeton) Johnston Christian W. (Neshanic Station) Seems George E. (Pennington NJ), Thermally reversible polyurethane hydrogels and cosmetic, biological and medical uses.
Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
Place Virgil A. ; Wilson Leland F. ; Doherty ; Jr. Paul C. ; Hanamoto Mark S. ; Spivack Alfred P. ; Gesundheit Neil ; Bennett Sean R., Treatment of female sexual dysfunction.
Virgil A. Place ; Leland F. Wilson ; Paul C. Doherty, Jr. ; Mark S. Hanamoto ; Alfred P. Spivack ; Neil Gesundheit ; Sean R. Bennett, Treatment of female sexual dysfunction using phosphodiesterase inhibitors.
Son Nguyen Kim DE; Axel Sanner DE; Karin Sperling-Vietmeier DE; Peter Hoessel DE, Use of cationic polyurethanes and polyureas as ingredients of cosmetic preparations.
Kanakaris Panagiotis,GRX ; Karouzakis Petros,GRX, Use of misoprostol or/and misoprostol acid for diagnosis of vascular damage in a subject with erectile dysfunction.
Leonardi Amedeo,ITX ; Motta Gianni,ITX ; Testa Rodolfo,ITX ; Sironi Giorgio,ITX, Use of selective antagonists of the .alpha.1B-adrenergic receptor for improvement of sexual dysfunction.
Leonardi, Amedeo; Motta, Gianni; Testa, Rodolfo; Sironi, Giorgio, Use of selective antagonists of the α1B-adrenergic receptor for improvement of sexual dysfunction.
Kim Son Nguyen,DEX ; Sanner Axel,DEX ; Kolter Karl,DEX, Use of water-soluble or water-dispersible polyurethanes as coatings or binders for pharmaceutical presentations.
Spijkers, Jozef C. W.; Van De Ven, Hendricus J. M.; Mezger, Thomas; Bontinck, Dirk; De Koninck, Luc, Water vapor permeable thermoplastic polyurethane film.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.