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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0767511 (2010-04-26) |
등록번호 | US-8362091 (2013-01-29) |
발명자 / 주소 |
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출원인 / 주소 |
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인용정보 | 피인용 횟수 : 67 인용 특허 : 474 |
A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting
A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
1. A foamable hygroscopic pharmaceutical composition in a pressurized container, the foamable hygroscopic pharmaceutical composition comprising: i) a carrier composition comprising: a. at least one hygroscopic substance selected from the group consisting of:a polyethylene glycol (PEG) and a polyol a
1. A foamable hygroscopic pharmaceutical composition in a pressurized container, the foamable hygroscopic pharmaceutical composition comprising: i) a carrier composition comprising: a. at least one hygroscopic substance selected from the group consisting of:a polyethylene glycol (PEG) and a polyol at a sufficient concentration to provide an Aw value of the hygroscopic pharmaceutical composition of less than 0.9;b. about 0.01% to about 5% by weight of the carrier composition of a gelling agent; andc. 0% to about 25% by weight of the carrier composition of water; andii) a liquefied or compressed gas propellant; wherein the foamable hygroscopic pharmaceutical composition forms a breakable foam upon release from the pressurized container; wherein the breakable foam does not immediately collapse upon exposure to skin temperature; and wherein the breakable foam breaks under shear force. 2. The hygroscopic pharmaceutical composition of claim 1, further comprising 0% to about 5% by weight of a surface-active agent; and a therapeutically effective concentration of one or more active agents. 3. A foamable pharmaceutical carrier composition in a pressurized container comprising: i) a carrier composition comprising: a. about 50% to about 98% by weight of the carrier composition of a polar solvent selected from the group consisting of (1) a polyol and (2) a polyethylene glycol (PEG);b. 0% to about 48% by weight of the carrier composition of a secondary polar solvent;c. about 0.01% to about 5% by weight of the carrier composition of a gelling agent; andd. 0% to about 25% by weight of the carrier composition of water; andii) a liquefied or compressed gas propellant; wherein the foamable pharmaceutical carrier composition forms a breakable foam upon dispensing from the pressurized container; wherein the breakable foam does not immediately collapse upon exposure to skin temperature; and wherein the breakable foam breaks under shear force. 4. The pharmaceutical composition of claim 3, wherein the gelling agent comprises a cellulose polymer. 5. The pharmaceutical composition of claim 3, wherein the polar solvent is a PEG selected from the group consisting of PEG 200, PEG 300, PEG 400, PEG 600, PEG 1000, PEG 4000, PEG 6000 and PEG 8000. 6. The pharmaceutical composition of claim 3, wherein the composition does not contain a surface-active agent. 7. The pharmaceutical composition of claim 3, further comprising a therapeutically effective concentration of one or more active agents. 8. The pharmaceutical composition of claim 3, wherein the polyol comprises at least one of glycerin, butane-1,2,3-triol, butane-1,2,4-triol, hexane-1,2,6-triol, propylene glycol, butanediol, butenediol, butynediol, pentanediol, hexanediol, octanediol, neopentyl glycol, 2-methyl-1,3-propanediol, diethylene glycol, triethylene glycol, tetraethylene glycol, dipropylene glycol, and dibutylene glycol or a mixture of at least two polyols. 9. The pharmaceutical composition of claim 3, wherein the polar solvent comprises a mixture of at least one polyol and at least one PEG. 10. The pharmaceutical composition of claim 3, wherein the pharmaceutical composition is substantially non-aqueous. 11. The pharmaceutical composition of claim 3, wherein the pharmaceutical composition is substantially free of short-chain alcohols. 12. The pharmaceutical composition of claim 3, wherein the pharmaceutical composition forms a stable foam at normal skin temperature for at least about 240 seconds upon release from the pressurized container. 13. The pharmaceutical composition of claim 3, further comprising about 0.2% to about 5% by weight of a surface-active agent. 14. The pharmaceutical composition of claim 13, wherein the surface-active agent comprises a non-ionic surfactant. 15. The pharmaceutical composition of claim 13, wherein the surface-active agent comprises at least one non-ionic surfactant and at least one ionic surfactant. 16. The pharmaceutical composition of claim 15, wherein the ratio of non-ionic surfactant to ionic surfactant is in the range of about 100:1 to about 6:1. 17. The pharmaceutical composition of claim 13, further comprising a hygroscopic substance selected from the group consisting of monosaccharides, disaccharides, oligosaccharides, sugar alcohols, honey and a PEG containing surfactant, wherein the composition can provide an Aw value of less than 0.9. 18. The pharmaceutical composition of claim 17, further comprising a therapeutically effective concentration of one or more active agents.
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